Translational Research

Stages Of Immunotherapy Development

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Immunotherapy has led to significant advances in our understanding and treatment of cancer. However, there is more work to be done since cancer continues to affect millions of individuals worldwide. Explore the stages of cancer immunotherapy development and discover tools that assist you with your discovery at every stage.

Translational Research

In translational research, early discovery insights are validated using multiple model systems. Potential therapeutics are further optimized for safety and efficacy in preparation for testing in humans during clinical trials. Potential biomarkers discovered during early research are also validated at this stage prior to in in-human studies. Development of the most pertinent model systems are key to ensuring success when translating the potential therapy from pre-clinical to clinical trials. Optimal purification processes and formulations for the therapeutics are also developed during early scale up activities.

Key Tools for Translational Research

Multiple cell-based assays are utilized in translational research. The automated ZE5 Cell Analyzer, which can examine up to 30 parameters simultaneously, easily analyzes rare or transient cell types in a high-throughput format. Additionally, potential immune or inflammation related protein biomarkers are screened, validated, and developed in animal models for future use in human clinical trials. The Bio-Plex Multiplex Immunoassay system to measures up to 500 proteins simultaneously and analyzes biomarkers in a high throughput, 96-well plate format, yielding thousands of accurate data points in less than 4 hours.

Companion Products

  • Droplet Digital™ PCR (ddPCR™) Systems, Primers, Assays, and Arrays

    Droplet Digital PCR (ddPCR) Systems, Reagents and Assays

    • Measure relevant biomarkers such as mutations, translocations, with high sensitivity and precision
    • Monitor minimum residual disease from limited amounts of starting material available from liquid biopsies
    • Obtain precise nucleic acid quantification from complex sample matrices such as FFPE
    • Obtain same day results from testing with fast workflow and simple data analysis
  • ddseq-single-cell-isolator

    ddSEQ Single Cell Isolator

    • Assess cell-to-cell heterogeneity and identify new sub-populations
    • Map cell trajectories, dissect transcriptional mechanics, and infer gene regulatory networks
    • Perform B Cell and T Cell subunit functional analyses
  • CFX Real-Time PCR Detection System

    CFX Real-Time PCR Detection System

    • High-performance PCR workflows to support gene expression assays as part of therapeutic discovery and development and biomarker discovery/validation
    • Powerful & flexible instruments with 2–5 color multiplexing to deliver sensitive, reliable detection of both single & multiplex RT-PCR reactions
    • Reagents optimized for your application including single cell GX, lncRNA, CNV, mutation & pathogen detection
  • Ze5™ Cell Analyzer

    ZE5 Cell Analyzer

    • Characterize animal models and cell therapies during pre clinical studies using multi-parameter cell analysis
    • Monitor up to 30 parameters using up to 5 lasers, to identify cell subtypes faster and with more precision, using up to 5 lasers, to identify cell subtypes faster and with more precision
    • Fast acquisition rate allows rare or transient cell types to be readily analyzed
  • S3e Cell Sorter

    S3e Cell Sorter

    • Sort and analyze cells at your bench to support therapeutic screening/preclinial studies
    • Up to 3 lasers to distinguish and sort subtly different cell populations
    • Cells are sorted quickly and gently while maintaining sensitivity and precision, which supports the sorting of fragile cell types
  • Gene Pulser Xcell™ Electroporation Systems

    Gene Pulser Xcell Electroporation Systems

    • Transfer genetic material via electroporation for cell/animal models and cell therapy development
    • Easy transfection using a library of electroporation protocols for every cell type including primary, immortal, and bacterial cells
    • Open system allows protocol optimization to ensure maximum transfection efficiencies
  • Gene Pulser Xcell™ Electroporation Systems

    Helios Gene Gun

    • Transfer genetic material via gene gun particle delivery into mammalian cells for cell/animal model or cell therapy development
    • Pressure and particle size can be optimized for your specific delivery/cell type need
    • No need for carrier DNA, so no extraneous proteins or genes are delivered
  • ZOE™ Fluorescent Cell Imager

    ZOE Fluorescent Cell Imager

    • Quickly monitor cells at your bench prior to, during and after assays used in translational research
    • Touch screen imaging software to view cells, capture images, and create multichannel merges
    • Flexible operation with brightfield and three fluorescence channels enables routine and more sophisticated imaging applications
  • TC20™ Automated Cell Counter

    TC20 Automated Cell Counter

    • Quantify cells prior to, during and after cell based assays during translational studies to ensure reproducibility
    • Monitor cell health and accurately count cells in less than 30 seconds in one simple step without the need for manual counting
  • Bio-Plex System

    Bio-Plex System and Assays

    • Measure multiple proteins simultaneously to validate biomarkers and monitor therapeutic safety/efficacy/toxicology
    • Measure up to 50, 100, or 500 proteins simultaneously, depending on your instrument, using off the shelf and customized panels
    • Small sample requirements (~25ul per well) means this multiplex assay is amenable to rare or small volume samples
  • NGC and Fraction Collector

    NGC Chromatography System and Fraction Collector

    • Flexible chromatography system with user-friendly, intuitive software to keep your lab running efficiently throughout translational research
    • Fraction collector works with plates, bottles and carboys to offer unrivaled flexibility in sample collection
    • Software allows for multi-parameter scouting which enables DOE for method development
  • Chromatography Resins & Columns

    Chromatography Resins & Columns

    • Bio-Rad resins can be used for lab scale and scale up purifications
    • Large variety of chromatographic resins for all chromatographic techniques with unique resin chemistries to improve your purification process
    • Resins to purify non-traditional drug formats such as antibody fragments, ADCs, bi-specific antibodies
  • V3 Western Workflow

    V3 Western Workflow

    • A five-step Western Blotting workflow that simplifies protein normalization and quantitation providing faster results for preclinical research
    • Analyze expression of multiple protein targets with multiplex imaging - chemiluminescence, fluorescence, or colorimetric
    • 21CFR Part 11 Compliant software and IQ/OQ/PQ available
  • Antibodies


    • View our primary and secondary antibodies for use in therapeutic discovery and development
    • Available for specific assay formats including Flow, ELISA, IHC/ICC, Western Blot, co-crystallization and affinity chromatography
    • For a range of research focuses - Immunology, Cancer, Stem cells, Cell biology
  • NGC and Fraction Collector

    Anti-Idiotypic Antibodies

    • Evaluate dose, efficacy, and toxicity during PK and ADA testing
    • For multiple assay formats including bridging and antigen capture
    • High quality standards to support regulatory compliance
  • HuCAL Custom Monoclonal Antibodies

    HuCAL Custom Monoclonal Antibodies

    • Custom antibody development and production within 8 weeks
    • Antibodies designed for specific assay formats including Flow, ELISA, IHC/ICC, Western Blot, co-crystallization and affinity chromatography
    • Highly specific, high affinity, recombinant monoclonal antibody with long term availability
  • qPCR

    CFX Real-Time PCR Systems

    • Utilized for protein stability and protein characterization work