ZOE Fluorescent Cell Imager

Overview

The ZOE Cell Imager simplifies fluorescence microscopy with an intuitive touch-screen interface to control the brightfield, three fluorescence channels, and integrated digital camera.

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Description

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The ZOE Fluorescent Cell Imager eliminates the complexities of cell imaging associated with traditional microscopes. This fluorescence imaging system combines the ease of use of a personal tablet with the power of an inverted microscope.

An Android-based platform, the ZOE Cell Imager uses an intuitive touch-screen interface to control the brightfield, three fluorescence channels, and the integrated digital camera.

The ZOE Fluorescent Cell Imager is a complete digital imaging system, allowing users to view samples, capture and store images, and create multicolor overlays. Thanks to the built-in light shield, the ZOE Cell Imager does not require a darkroom for fluorescence imaging.

Features and Benefits of the ZOE Fluorescent Cell Imager

Simplified cell imaging — the intuitive touch-screen interface allows users to view cells, capture images, and create multichannel merges with minimal training
Flexible operation — brightfield and three fluorescence channels enable use for routine cell culture applications and more sophisticated imaging applications
Fluorescence imaging at your bench — light shield permits fluorescence imaging in ambient light
Robust construction — fully integrated system with long-life LEDs, ready for intensive daily use
LED light sources — thousands of hours of illumination that are instantly ready after power-on
Large viewing area — the motorized stage and wide field of view allow you to see more of your sample, faster
Small footprint — compact size accommodates crowded lab benches

Applications of the ZOE Fluorescent Cell Imager

Use the ZOE Cell Imager to check/screen samples prior to high-content analysis (HCA), high-throughput screening (HCS), confocal imaging, or fluorescence-activated cell sorting (FACS). With a brightfield and three fluorescent channels, the ZOE Cell Imager has all the features needed for daily cell culture work as well as fluorescent applications:

Visual estimation of cell confluency
Observation of general cell health and morphology
Cell growth and proliferation monitoring
Capturing cell images (with or without fluorescent labels)
Visualization of expressed fluorescent proteins
Immunofluorescent protein localization
Estimation of transfection efficiency

Illumination Light Sources

Blue channel uses a UV LED
Green channel uses a blue LED
Red channel uses a green LED
Brightfield channel uses a ring of multiple green LEDs for reduced chromatic aberration

Fluorophores Compatible with the ZOE Fluorescent Cell Imaging System

This is not a comprehensive list; other dyes and fluorescent proteins with compatible excitation and emission spectra can also be used.

Blue Channel Excitation: 355/40 nm Emission: 433/36 nm	Green Channel Excitation: 480/17 nm Emission: 517/23 nm	Red Channel Excitation: 556/20 nm Emission: 615/61 nm
PureBlu DAPI Nuclear Staining Dye	CytoTrack Green 511/525	ReadiLink 555/570 Antibody Labeling Kit
PureBlu Hoechst 33342 Nuclear Staining Dye	ReadiLink 492/516 Antibody Labeling Kit	ReadiLink 594/610 Antibody Labeling Kit
ReadiLink 350/440 Antibody Labeling Kit	VivaFix 498/521 Cell Viability Assay*	VivaFix 547/573 Cell Viability Assay
VivaFix 353/442 Cell Viability Assay	CFDA-SE	VivaFix 583/603 Cell Viability Assay
Alexa Fluor 350	Acridine Orange	Alexa Fluor 546
Alexa Fluor 405	Alexa Fluor 488 dye*	Alexa Fluor 568
Cascade Blue	BODIPY Fl*	Alexa Fluor 594
CellTracker Blue	Calcein AM	Alexa Fluor 610
DAPI*	DiO	Cy3*
Hoechst*	EGFP*	Dil Stain
LysoTracker Blue	ER-Tracker Green	DsRed*
Marina Blue	FITC*	ER-Tracker Red
NucBlue Fixed	MitoTracker Green FM	mCherry*
NucBlue Live	SYTO 9, SYTO 13, SYTO 16	mStrawberry
—	SYTOX Green	MitoTracker Red*
—	Tubulin Green	mKate*
—	YFP*	RFP*
—	—	SYTOX Orange
—	—	SYTO 84, SYTO 85
—	—	Texas Red*

* R&D Tested

Related Technologies

Related Products

Specifications

Imaging channels

Brightfield channel and 3 fluorescence channels (blue, green, and red)

Light source

Blue channel: UV LED
Green channel: blue LED
Red channel: green LED
Brightfield channel: multiple green LEDs (reduces chromatic aberration)

User interface

10.1 in. color (26 cm) touch-screen LCD monitor, with anti-glare and anti-fingerprint treatment, 1,280 x 768 pixel image resolution, 80–180° angle tilt range

Focusing mechanism

Coarse and fine, manual adjustment

Camera

Monochrome camera, 12 bit CMOS, 5 megapixels

Data format

JPEG, TIFF, or RAW image files

Image merge

Images from up to 4 channels can be overlaid

Data storage

16 GB internal memory (~2,500 JPEG files,1,500 TIFF files, 400–800 RAW files)

Data export

Yes, 2 USB ports

Display output

Yes, 1 HDMI port

Objective

20x

Numerical aperture

0.40

Display magnification

Standard: 175x; zoom: 700x

Maximum imaging area

0.70 mm² field of view

Motorized stage

6 mm travel in X, Y direction, touch-screen control of travel speed and direction

Compatible with

Flasks: T25, T75, or T225
Multiwell plates: 6-, 12-, 24-, 48-, 96-, or 384-well microplates
Dishes: 35 mm, 60 mm, or 100 mm
Slides: chamber slides or standard glass microscopy slides

Software

Stand-alone Android operating system; PC is not required for operation

Instrument size (L x W x H)

33 x 32 x 30 cm (13 x 12.6 x 11.6 in.)

Instrument weight

9 kg (19.7 lb)

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(Discontinued) ZOE™ Fluorescent Cell Imager

1450031

Stand-alone fluorescent cell imager, includes instrument, power supply, USB flash drive; 120–240 V

Kits & Reagents

(Discontinued) ReadiLink 350/440 Antibody Labeling Kit

1351001

Pkg of 1, kit includes dye, reaction buffer, and quench buffer for labeling 2 x 50 µg of antibodies

(Discontinued) ReadiLink 492/516 Antibody Labeling Kit

1351002

Pkg of 1, kit includes dye, reaction buffer, and quench buffer for labeling 2 x 50 µg of antibodies

(Discontinued) ReadiLink 555/570 Antibody Labeling Kit

1351003

Pkg of 1, kit includes dye, reaction buffer, and quench buffer for labeling 2 x 50 µg of antibodies

(Discontinued) ReadiLink 594/610 Antibody Labeling Kit

1351004

Pkg of 1, kit includes dye, reaction buffer, and quench buffer for labeling 2 x 50 µg of antibodies

(Discontinued) VivaFix™ 353/442 Cell Viability Assay

1351111

Pkg of 1, kit includes 4 x 50 assay vials and 250 µl of DMSO, for running 200 assays

(Discontinued) VivaFix™ 498/521 Cell Viability Assay

1351115

Pkg of 1, kit includes 4 x 50 assay vials and 250 µl of DMSO, for running 200 assays

(Discontinued) VivaFix™ 547/573 Cell Viability Assay

1351116

Pkg of 1, kit includes 4 x 50 assay vials and 250 µl of DMSO, for running 200 assays

(Discontinued) VivaFix™ 583/603 Cell Viability Assay

1351117

Pkg of 1, kit includes 4 x 50 assay vials and 250 µl of DMSO, for running 200 assays

(Discontinued) CFDA-SE

1351201

Pkg of 1, 5 x 100 µg vials

(Discontinued) PureBlu™ DAPI Nuclear Staining Dye

1351303

Pkg of 5 vials, 50 µg each, DAPI nuclear staining dye powder

(Discontinued) PureBlu™ Hoechst 33342 Nuclear Staining Dye

1351304

Pkg of 5 vials, 56 µg each, Hoechst 33342 nuclear staining dye powder

Download

ZOE Fluorescent Cell Imager Software and Firmware

SOFT-ZOE-Cell-Imager-UI-FW

Software and firmware update for the ZOE Cell Imager.
Vision board driver version: 2.009. Driver board firmware version: 1.033. ZOE Cell Image Software version: 2.257

Download Software

Software Download

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Export of any Bio-Rad product or technical information relating to the product (i.e., manuals, memoranda, specifications, schematics, etc.) outside of the United States is subject to U.S. export control laws, including but not limited to the U.S. Export-Re-export Requirements and Enhanced Proliferation Control Initiative.

You agree that, unless You receive prior authorization from the United States government, You and/or Your organization shall not:

use any Bio-Rad product if You are located in, under the control of, or a national or resident of any embargoed or restricted* countries (Cuba, Iran, *North Korea, Sudan, and *Syria); or
sell, license, or otherwise provide or ship, directly or indirectly, any Bio-Rad product or technical data (or the direct product thereof) for export or re-export to the embargoed or restricted* countries (Cuba, Iran, *North Korea, Sudan, and *Syria); or
transfer, export or re-export any Bio-Rad product to Your customers or any intermediate entity in the chain of supply if any Bio-Rad product will be used in the design, development, production, stockpiling or use of missiles, chemical or biological weapons or for nuclear end uses; or
transfer, export or re-export, directly or indirectly, any Bio-Rad product, technology or software (or any part thereof, or the product of such technology or software, or any process or service which is the product of such technology or software) to any person or entity identified by the U.S. Department of Commerce as a sanctioned and/or embargoed person or entity. (For a current list of all sanctioned and/or embargoed persons or entities, please consult the U.S. Department of Commerce).

All rights to use the Bio-Rad product(s) are granted on condition that such rights are forfeited if You fail to comply with the terms of these Export Compliance Requirements.

For more information regarding U.S. export laws and regulations, contact the U.S. Department of Commerce and the U.S. Department of the Treasury, Office of Foreign Assets Control.

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Documents

Number Description Options

6865

ZOE Fluorescent Cell Imager Publication List, Ver A

6585

ZOE™ Fluorescent Cell Imager Brochure, Rev A

[ Add to Cart (Free) ]

10041704

ZOE Fluorescent Cell Imager Instruction Manual

10041709

ZOE™ Fluorescent Cell Imager Quick Guide, Rev B

6853

Reliable Single-Cell Sorting with Bio-Rad's S3e™ Cell Sorter Application Note

ZOE Fluorescent Cell Imager