Drug Discovery and Development

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Overview

Bio-Rad offers products and services to accelerate the drug discovery and development journey, from target identification through scale-up to manufacturing. We understand that consistency, reproducibility, and reliability are critical to your research, so our products are developed and manufactured to the highest quality standards. We know that maintaining high productivity is a constant challenge, so our products are easy to use and designed to automate steps of your workflow, reducing hands-on time and freeing you to focus on your most critical tasks.

Drug Discovery and DevelopmentBio-Rad is ISO-certified with cGMP facilities set up to ensure our products meet the stringent requirements of regulatory agencies. We have experience working directly with the FDA and regularly assist our customers with audit requirements. We offer solutions that are customizable to fit perfectly with your needs in drug discovery, development, and manufacturing and help you drive efficiency in target identification, candidate screening, assay development, and protein or antibody production, from small scale to large scale.

 

Solutions to Support Your Research from Target Discovery to Manufacturing

Stages of Drug Discovery and Development

Target Discovery: Identification and Validation
Identifying a potential drug target for a disease or condition for which no treatment exists or current therapies are inadequate

Preclinical Research
Animal studies plus cellular and biochemical assays to characterize the pharmacology of lead drug candidates including toxicity, PK/PD, ADME, and NOAEL

Process Development and Scale-Up
Production of increasing quantities of a candidate drug from discovery through development, trials, and approval

Lead Discovery: Screening and Optimization
Therapeutic lead identification and screening to determine biological activity, selectivity, toxicity, and mechanism of action

Clinical Research
Testing of a new drug candidate in humans to evaluate the safety and efficacy in treating or preventing a disease, dosing regimen, and side effects

Pharmaceutical Manufacturing and Release Testing
Large-scale manufacturing of a new drug, cGMP process control, product QC, and stability testing of the finished product

Download Bulletin 6877

Bio-Rad's Drug Discovery and Development Workflow Solutions

Learn how Bio-Rad's products align with your drug discovery and development workflows.

 

Additional Methodologies used in Drug Discovery and Development

Biomarker Discovery

Biomarker Discovery and Validation
The use of biomarkers across drug discovery and development and into the clinic is key to enabling close monitoring of a drug candidate’s effects. Biomarkers can be molecular, such as a protein level or gene expression, or physiological parameters such as blood pressure. Biomarker validation demonstrates that their levels are consistently correlated with treatment parameters, allowing the development of marker-based assays for evaluating patient response to a drug.

Biochemical and Cellular Assays

Biochemical and Cellular Assays
Biochemical and cellular pharmacology teams develop and validate assays to support research across drug discovery and development. These assays range from discovery approaches with high sample throughput to high-content analysis to gain an understanding of biological response both in vitro and in vivo.

Biosimilars

Biosimilar Development
A biosimilar, essentially a copy of its biological reference product, requires physicochemical and functional characterization using multiple analytical techniques to ensure similarity. In vitro, in vivo, and functional assays should demonstrate that the proposed biosimilar actually has highly similar biological activity and potency compared to the reference product.

 

Instrument Validation, Service, and Technical Support

Technical Support

Technical Support
Reach our award-winning technical team by phone or email

Validation

Instrument Validation and CFR-Compliant Software
Self-service and field based IQ/OQ options, and 21 CFR Part 11 regulatory-compliant instrument software

Expert Care

Expert Care Service Plans
Service options to cover IQ/OQ,  preventive maintenance, and remote and onsite service

ISO Certificates

ISO Certificates
U.S. Manufacturing ISO 9001:2008
U.K. Antibody Manufacturing ISO 9001:2008
U.K. Sales, Distribution, and Service ISO 9001:2015, ISO 13485:2012
Singapore Manufacturing ISO 9001:2008, ISO 13485:2003

 
NU4EE515 [x-forwarded-proto] = [https] [x-forwarded-port] = [443] [x-forwarded-for] = [185.145.200.60, 10.232.2.104] [seourl] = [/en-us/applications-technologies/drug-discovery-development] [x-amzn-trace-id] = [Root=1-5d879bda-d96eb40c8adc648c3c18ffe7] [x-forwarded-server] = [lsds-prod-s.br.aws-livesite.io] [x-forwarded-host] = [www.bio-rad.com] [x-query-string] = [ID=NU4EE515] [host] = [10.232.16.28:1776] [x-request-uri] = [/en-us/applications-technologies/drug-discovery-development] [connection] = [Keep-Alive] [accept-encoding] = [identity] [user-agent] = [Mozilla/5.0 (compatible; Googlebot/2.1; +http://www.google.com/bot.html)] AppTech/AppTechDetails pageStyleKey internet/solutions_sub applications-technologies/drug-discovery-development LSR NU4EE515 Drug Discovery Drug Discovery and Development /webroot/web/html/lsr/solutions/applications/drug_discovery /webroot/web/images/lsr/solutions/applications/drug_discovery/cat-drug-discovery-icon.jpg Drug Discovery and Development <script type="text/javascript">// <![CDATA[ $(document).ready(function(){ $('.analysismethods').hide(); $('.pagecontent2').hide(); }); // ]]></script> <p>Bio-Rad offers products and services to accelerate the drug discovery and development journey, from target identification through scale-up to manufacturing. We understand that consistency, reproducibility, and reliability are critical to your research, so our products are developed and manufactured to the highest quality standards. We know that maintaining high productivity is a constant challenge, so our products are easy to use and designed to automate steps of your workflow, reducing hands-on time and freeing you to focus on your most critical tasks.<br /><br /> <img style="margin-left: 20px;" src="/webroot/web/images/lsr/solutions/applications/drug_discovery/drug-discovery-and-development-image.jpg" alt="Drug Discovery and Development" align="right" />Bio-Rad is ISO-certified with cGMP facilities set up to ensure our products meet the stringent requirements of regulatory agencies. We have experience working directly with the FDA and regularly assist our customers with audit requirements. We offer solutions that are customizable to fit perfectly with your needs in drug discovery, development, and manufacturing and help you drive efficiency in target identification, candidate screening, assay development, and protein or antibody production, from small scale to large scale.</p> Solutions to Support Your Research from Target Discovery to Manufacturing <div class="ddflow-container"> <ul class="ddflow ddflow-main"> <li><a href="target-discovery-identification-validation">Target <br />Discovery<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-target-discovery.jpg" alt="Target Discovery" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li><a href="lead-discovery-screening-optimization">Lead <br />Discovery<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-lead-discovery.jpg" alt="Lead Discovery" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li><a href="preclinical-research">Preclinical <br />Research<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-preclinical-research.jpg" alt="Preclinical Research" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li><a href="clinical-research">Clinical <br />Research<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-clincal-research.jpg" alt="Clinical Research" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li><a href="process-development-scale">Process <br />Development<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-process-development.jpg" alt="Process Development" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li><a href="pharmaceutical-manufacturing-release-testing">Manufacturing<br />and Testing<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-manufacturing.jpg" alt="Pharmaceutical Manufacturing and Release Testing" /></div> </a></li> </ul> </div> <p class="caption"><strong>Stages of Drug Discovery and Development</strong></p> <table class="pd_table" border="0"> <tbody> <tr> <td style="padding-left: 0;" width="180px" align="left" valign="top"> <p><a href="target-discovery-identification-validation"><strong>Target Discovery: Identification and Validation</strong></a><br /> Identifying a potential drug target for a disease or condition for which no treatment exists or current therapies are inadequate</p> </td> <td width="180px" align="left" valign="top"> <p><a href="preclinical-research"><strong>Preclinical Research</strong></a><br />Animal studies plus cellular and biochemical assays to characterize the pharmacology of lead drug candidates including toxicity, PK/PD, ADME, and NOAEL</p> </td> <td width="180px" align="left" valign="top"> <p><a href="process-development-scale"><strong>Process Development and Scale-Up</strong></a><br />Production of increasing quantities of a candidate drug from discovery through development, trials, and approval</p> </td> </tr> <tr> <td style="padding-left: 0;" width="180px" align="left" valign="top"> <p><a href="lead-discovery-screening-optimization"><strong>Lead Discovery: Screening and Optimization</strong></a><br /> Therapeutic lead identification and screening to determine biological activity, selectivity, toxicity, and mechanism of action</p> </td> <td width="180px" align="left" valign="top"> <p><a href="clinical-research"><strong>Clinical Research</strong></a><br />Testing of a new drug candidate in humans to evaluate the safety and efficacy in treating or preventing a disease, dosing regimen, and side effects</p> </td> <td width="180px" align="left" valign="top"> <p><a href="pharmaceutical-manufacturing-release-testing"><strong>Pharmaceutical Manufacturing and Release Testing</strong></a><br />Large-scale manufacturing of a new drug, cGMP process control, product QC, and stability testing of the finished product</p> </td> </tr> </tbody> </table> <div class="corner-box corner-box-pdf"><a class="no-target-style" href="/webroot/web/pdf/lsr/literature/Bulletin_6877.pdf" target="_blank" rel="noopener noreferrer"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/download-icon.png" alt="Download Bulletin 6877" /></a> <h3><a class="no-target-style" href="/webroot/web/pdf/lsr/literature/Bulletin_6877.pdf" target="_blank" rel="noopener noreferrer">Bio-Rad's Drug Discovery and Development Workflow Solutions</a></h3> <p><strong>Learn how Bio-Rad's products align with your drug discovery and development workflows.</strong></p> </div> Additional Methodologies used in Drug Discovery and Development <table class="pd_table" border="0"> <tbody> <tr> <td align="left" valign="top"> <p><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/biomarker-discovery.jpg" alt="Biomarker Discovery" /></p> </td> <td align="left" valign="top"> <p><a href="/en-us/applications-technologies/biomarker-discovery"><strong>Biomarker Discovery and Validation </strong></a><br />The use of biomarkers across drug discovery and development and into the clinic is key to enabling close monitoring of a drug candidate&rsquo;s effects. Biomarkers can be molecular, such as a protein level or gene expression, or physiological parameters such as blood pressure. Biomarker validation demonstrates that their levels are consistently correlated with treatment parameters, allowing the development of marker-based assays for evaluating patient response to a drug.</p> </td> </tr> <tr> <td align="left" valign="top"> <p><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/biochemical-and-cellular-assays.jpg" alt="Biochemical and Cellular Assays" /></p> </td> <td align="left" valign="top"> <p><a href="/en-us/applications-technologies/biochemical-cellular-assays"><strong>Biochemical and Cellular Assays</strong></a><br />Biochemical and cellular pharmacology teams develop and validate assays to support research across drug discovery and development. These assays range from discovery approaches with high sample throughput to high-content analysis to gain an understanding of biological response both in vitro and in vivo.</p> </td> </tr> <tr> <td align="left" valign="top"> <p><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/biosimilars.png" alt="Biosimilars" /></p> </td> <td align="left" valign="top"> <p><a href="/en-us/applications-technologies/biosimilar-development?ID=OX1XCO15"><strong>Biosimilar Development</strong></a><br />A biosimilar, essentially a copy of its biological reference product, requires physicochemical and functional characterization using multiple analytical techniques to ensure similarity. In vitro, in vivo, and functional assays should demonstrate that the proposed biosimilar actually has highly similar biological activity and potency compared to the reference product.</p> </td> </tr> </tbody> </table> Instrument Validation, Service, and Technical Support <table class="pd_table" border="0"> <tbody> <tr> <td align="left" valign="top"> <p><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/tech-support.gif" alt="Technical Support" /></p> </td> <td align="left" valign="top"> <p><a href="/en-us/applications-technologies/technical-support-for-drug-discovery-development-researchers"><strong>Technical Support</strong></a><br /> Reach our award-winning technical team by phone or email</p> </td> <td align="left" valign="top"> <p><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/validation.jpg" alt="Validation" /></p> </td> <td align="left" valign="top"> <p><a href="/en-us/applications-technologies/instrument-validation-cfr-compliant-software"><strong>Instrument Validation and CFR-Compliant Software</strong></a><br /> Self-service and field based IQ/OQ options, and 21 CFR Part 11 regulatory-compliant instrument software</p> </td> </tr> <tr> <td align="left" valign="top"> <p><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/expert-care.jpg" alt="Expert Care" /></p> </td> <td align="left" valign="top"> <p><a href="/en-us/life-science-research/support/purchasing-service-programs?ID=LUL9IQ4VY"><strong>Expert Care Service Plans</strong></a><br /> Service options to cover IQ/OQ,&nbsp; preventive maintenance, and remote and onsite service</p> </td> <td align="left" valign="top"> <p><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/bio-rad-iso-cert.jpg" alt="ISO Certificates" /></p> </td> <td align="left" valign="top"> <p><strong>ISO Certificates</strong><br /> <span class="no-target-style">U.S. Manufacturing</span> <a href="/webroot/web/pdf/lsr/literature/US-ISO-9001-2008-Certificate.pdf" target="_blank" rel="noopener noreferrer">ISO 9001:2008</a><br /> <span class="no-target-style">U.K. Antibody Manufacturing</span> <a href="/webroot/web/pdf/lsr/literature/UK_ISO_9001_2008_Certificate_AbD_Serotec.pdf" target="_blank" rel="noopener noreferrer">ISO 9001:2008</a><br /> <span class="no-target-style">U.K. Sales, Distribution, and Service</span> <a href="/webroot/web/pdf/lsr/literature/BSI_ISO_9001%202015.pdf" target="_blank" rel="noopener noreferrer">ISO 9001:2015</a>, <a href="/webroot/web/pdf/lsr/literature/BSI_ISO_13485%202012.pdf" target="_blank" rel="noopener noreferrer">ISO 13485:2012</a><br /> <span class="no-target-style">Singapore Manufacturing <a href="/webroot/web/pdf/lsr/literature/SG-ISO-9001-2008-13485-2003-Certificate.pdf" target="_blank" rel="noopener noreferrer">ISO 9001:2008, ISO 13485:2003</a><br /></span></p> </td> </tr> </tbody> </table> Karen Moss Drug Discovery and Development <p>Bio-Rad products and services span the entire range of drug discovery and development activities, from target identification to scale-up and manufacturing.</p> drug discovery, discovery, drug development, development, pharma, pharmaceutical 10/06/15 11:33 AM 10/06/25 11:53 AM AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA,VN en LSR /LSR/Applications/Drug_Discovery N 0
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