- Target
Discovery
- Lead
Discovery
- Preclinical
Research
- Clinical
Research
- Process
Development
- Manufacturing
and Testing
During the preclinical stage, studies in animal models are combined with cellular and biochemical assays to understand the effects of lead drug candidates and provide detailed reporting on the pharmacological profile, acute toxicity in at least two animal species, and short-term toxicity studies. Early dosage studies are also performed to guide the implementation of subsequent clinical phases. Show more
Testing includes the pharmacology of absorption, distribution, metabolism, and excretion (ADME), metabolic stability, pharmacokinetics, immunogenicity/ADA, biomarker analysis, and the mutagenicity, reproductive effects, and in vitro and in vivo toxicity of candidates and their metabolites. Data from this phase are used to determine whether to proceed to human testing, and the no observable adverse effect levels (NOAELs) are used to guide starting dosages in clinical trials. Show less
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Gene ExpressionRapidly evaluate responses in metabolic, signaling, and other biological pathways and characterize mutagenesis with predesigned, validated qPCR and Droplet Digital™ PCR Assays and automated real-time PCR systems and ddPCR™ Systems. Droplet Digital PCR Systems
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Protein PurificationDevelop large-scale purification strategies for your protein or antibody drug using our range of chromatography resins (media). NGC™ Medium-Pressure Chromatography Systems |
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Protein AnalysisExplore our tools and assays for the identification, and analysis of protein profiles to support ADME and biomarker studies. Multiplex Cancer Immunoassays |
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Cell AnalysisView changes in cell phenotype upon introduction of a drug using our advanced cell analysis systems. Develop robust cell-based screening assays using our fast, highly sensitive cell counting, cell sorting, and flow cytometry instrumentation. Our comprehensive range of antibodies and custom options allows you to monitor safety, ADME, and toxicity with ease. Cell Imaging |
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AntibodiesChoose from an extensive range of antibodies for use in your preclinical testing assays or utilize our custom antibody services. Antibodies by Application |
Biochemical and Cellular Assays
In vitro and in vivo discovery approaches with high sample throughput and high-content analysis to characterize biological responses.
Biomarker Discovery & Validation
Biomarker monitoring across drug discovery, development, and clinical stages is key to defining drug effects.
Biologic Development
Biologic development brings patients closer to personalized medicine to treat health problems.
Biosimilar Development
Biosimilar development requires physicochemical and functional characterization to ensure similarity.
Cancer Immunotherapy Development
Learn about trends in cancer immunotherapy development, such as CAR-T, and tools for genomic, cellular, and proteomic research.
CRISPR Gene Editing
CRISPR enables researchers to edit their desired target genes efficiently and accelerate drug development.
Viral Vector Vaccine Development
The COVID-19 pandemic opened the door to expedited vaccine development using new technologies and therapies that have traditionally been used in other applications.