Preclinical Research

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Overview

 

During the preclinical stage, studies in animal models are combined with cellular and biochemical assays to understand the effects of lead drug candidates and provide detailed reporting on the pharmacological profile, acute toxicity in at least two animal species, and short-term toxicity studies. Early dosage studies are also performed to guide the implementation of subsequent clinical phases. Show more

Testing includes the pharmacology of absorption, distribution, metabolism, and excretion (ADME), metabolic stability, pharmacokinetics, immunogenicity/ADA, biomarker analysis, and the mutagenicity, reproductive effects, and in vitro and in vivo toxicity of candidates and their metabolites. Data from this phase are used to determine whether to proceed to human testing, and the no observable adverse effect levels (NOAELs) are used to guide starting dosages in clinical trials. Show less

 
 

Feature Article and Video

Bio-Rad's Drug Discovery and Development Workflow Solutions
Learn how Bio-Rad's products align with your drug discovery and development workflows  Download

Development of Recombinant Antibodies for PK/PD and Immunogenicity Assays 
Watch Video


 

Solutions for Preclinical Research

Gene Expression

Gene Expression

Rapidly evaluate responses in metabolic, signaling, and other biological pathways and characterize mutagenesis with Droplet Digital™ PCR Assays and automated real-time PCR systems and ddPCR™ Systems.

Droplet Digital PCR Systems
Real-Time PCR Automation

PCR Instrument Validation Tools and Services

 

Protein Purification and Analysis

Protein Purification

Develop large-scale purification strategies for your protein or antibody drug using our range of chromatography resins (media).

NGC™ Medium-Pressure Chromatography Systems
Chromatography Columns and Resins

Protein Expression

Protein Analysis

Explore our tools and assays for the identification, and analysis of protein profiles to support ADME and biomarker studies.

Multiplex Cancer Immunoassays
Western Blotting Reagents and Equipment

Cell Analysis

Cell Analysis

View changes in cell phenotype upon introduction of a drug using our advanced cell analysis systems. Develop robust cell-based screening assays using our fast, highly sensitive cell counting, cell sorting, and flow cytometry instrumentation. Our comprehensive range of antibodies and custom options allows you to monitor safety, ADME, and toxicity with ease.

Cell Imaging
Cell Counting
Cell Sorting and Flow Cytometry
Antibodies for Flow Cytometry

Antibodies

Antibodies

Choose from an extensive range of antibodies for use in your preclinical testing assays or utilize our custom antibody services.

Antibodies by Application
Antibodies by Target Species
Cell Signaling Antibodies
HuCAL® Custom Antibody Services

 

Additional Methodolgies and Research Within Drug Discovery and Development

Biomarker Discovery

Biomarker Discovery
The use of biomarkers across drug discovery and development and into the clinic is key to enabling close monitoring of a drug candidate’s effects. Biomarkers can range from specific molecules such as a protein, a gene sequence, or expressed RNA to physiological parameters such as blood pressure. Biomarkers may be detected in a specific location or tissue or in plasma and other bodily fluids.

Biochemical and Cellular Assays

Biochemical and Cellular Assays
Biochemical and cellular pharmacology teams develop and validate assays to support research across drug discovery and development. These assays range from discovery approaches with high sample throughput to high-content analysis to gain an understanding of biological response both in vitro and in vivo.

 
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Early dosage studies are also performed to guide the implementation of subsequent clinical phases.<span class="content-show" style="display:inline"> Show more</span></p> <p class="content-more">Testing includes the pharmacology of absorption, distribution, metabolism, and excretion (ADME), metabolic stability, pharmacokinetics, immunogenicity/ADA, biomarker analysis, and the mutagenicity, reproductive effects, and in vitro and in vivo toxicity of candidates and their metabolites. Data from this phase are used to determine whether to proceed to human testing, and the no observable adverse effect levels (NOAELs) are used to guide starting dosages in clinical trials. <span class="content-hide">Show less</span></p> &nbsp; Feature Article and Video <table border="0"> <tbody> <tr valign="top"> <td width="50%" height="100"> <p><a href="/webroot/web/pdf/lsr/literature/Bulletin_6877.pdf" target="_blank"><img style="float:left; margin-right:10px" src="/webroot/web/images/lsr/solutions/applications/drug_discovery/6877-thumb.jpg" alt="" width="57" height="72" /></a><strong>Bio-Rad's Drug Discovery and Development Workflow Solutions</strong><br />Learn how Bio-Rad's products align with your drug discovery and development workflows &nbsp;<a href="/webroot/web/pdf/lsr/literature/Bulletin_6877.pdf" target="_blank">Download</a></p> </td> <td width="50%"> <p><a href="javascript:openAjaxOverlay(&quot;/webroot/web/html/lsr/solutions/applications/drug_discovery/ov-pkpd-video.html&quot;);"><img style="float:left; margin-right:10px" src="/webroot/web/images/lsr/solutions/applications/drug_discovery/pkpd-video-thumb.jpg" alt="" width="57" height="72" /></a> Development of Recombinant Antibodies for PK/PD and Immunogenicity Assays&nbsp;<br /><a href="javascript:openAjaxOverlay(&quot;/webroot/web/html/lsr/solutions/applications/drug_discovery/ov-pkpd-video.html&quot;);">Watch Video</a></p> </td> </tr> </tbody> </table> <br /> Solutions for Preclinical Research <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top:0px"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/gene-expression.jpg" alt="Gene Expression" /></p> </td> <td align="left" valign="top"> <h4>Gene Expression</h4> <p style="margin-top:-7px">Rapidly evaluate responses in metabolic, signaling, and other biological pathways and characterize mutagenesis with <span class="hidden US-only CA-only AT-only BE-only DK-only FI-only FR-only DE-only IT-only LU-only NO-only PT-only ES-only NL-only SE-only CH-only UK-only AU-only NZ-only SG-only">predesigned, validated qPCR and </span> Droplet Digital&trade; PCR Assays and automated real-time PCR systems and ddPCR&trade; Systems.</p> <p><a href="/en-us/category/digital-pcr">Droplet Digital PCR Systems</a><br /> <a href="/en-us/product/cfx-automation-system-ii">Real-Time PCR Automation</a><br /></p> <div id="pcrPrimersprobesassaysLink" style="margin:-10px 0 -0px 0"> <script type="text/javascript"><!-- $('#pcrPrimersprobesassaysLink').load('/webroot/web/html/lsr/products/amplification_pcr/pcr-primers-probes-assays-link.html'); // --></script> </div> <a href="/en-us/category/pcr-instrument-validation-tools-services">PCR Instrument Validation Tools and Services</a> <p>&nbsp;</p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top:0px"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/protein-purification-analysis.jpg" alt="Protein Purification and Analysis" /></p> </td> <td align="left" valign="top"> <h4>Protein Purification</h4> <p style="margin-top:-7px">Develop large-scale purification strategies for your protein or antibody drug using our range of chromatography resins (media).</p> <p><a href="/en-us/category/ngc-medium-pressure-liquid-chromatography-systems">NGC&trade; Medium-Pressure Chromatography Systems </a><br /> <a href="/en-us/category/chromatography-columns">Chromatography Columns and Resins</a></p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top:0px"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/protein-expression.jpg" alt="Protein Expression" /></p> </td> <td align="left" valign="top"> <h4>Protein Analysis</h4> <p style="margin-top:-7px">Explore our tools and assays for the identification, and analysis of protein profiles to support ADME and biomarker studies.</p> <p><a href="/en-us/product/bio-plex-pro-human-cancer-biomarker-assays">Multiplex Cancer Immunoassays </a><br /> <a href="/en-us/category/western-blotting">Western Blotting Reagents and Equipment</a></p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top:0px"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/cell-analysis.jpg" alt="Cell Analysis" /></p> </td> <td align="left" valign="top"> <h4>Cell Analysis</h4> <p style="margin-top:-7px">View changes in cell phenotype upon introduction of a drug using our advanced cell analysis systems. Develop robust cell-based screening assays using our fast, highly sensitive cell counting, cell sorting, and flow cytometry instrumentation. Our comprehensive range of antibodies and custom options allows you to monitor safety, ADME, and toxicity with ease.</p> <p><a href="/en-us/category/cell-imaging">Cell Imaging</a><br /><a href="/en-us/category/cell-counting">Cell Counting</a><br /> <a href="/en-us/category/flow-cytometry">Cell Sorting and Flow Cytometry</a><br /> <a href="/en-us/product/flow-cytometry-antibodies">Antibodies for Flow Cytometry</a></p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr> <td align="left" valign="top"> <p><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/antibodies.jpg" alt="Antibodies" /></p> </td> <td align="left" valign="top"> <h4>Antibodies</h4> <p style="margin-top:-7px">Choose from an extensive range of antibodies for use in your preclinical testing assays or utilize our custom antibody services.</p> <p><a class="new-target-image" href="https://www.abdserotec.com/antibody-applications.html" target="_blank">Antibodies by Application </a><br /> <a class="new-target-image" href="https://www.abdserotec.com/antibodies-by-target-species.html" target="_blank">Antibodies by Target Species </a><br /> <a class="new-target-image" href="https://www.abdserotec.com/cell-biology-antibodies.html" target="_blank">Cell Signaling Antibodies</a><br /> <a class="new-target-image" href="https://www.abdserotec.com/custom-antibody-services.html" target="_blank">HuCAL<sup>&reg;</sup> Custom Antibody Services </a></p> </td> </tr> </tbody> </table> Additional Methodolgies and Research Within Drug Discovery and Development <table class="pd_table" border="0"> <tbody> <tr> <td align="left" valign="top"> <p><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/biomarker-discovery.jpg" alt="Biomarker Discovery" /></p> </td> <td align="left" valign="top"> <p><a href="/en-us/applications-technologies/biomarker-discovery"><strong>Biomarker Discovery</strong></a><br />The use of biomarkers across drug discovery and development and into the clinic is key to enabling close monitoring of a drug candidate&rsquo;s effects. Biomarkers can range from specific molecules such as a protein, a gene sequence, or expressed RNA to physiological parameters such as blood pressure. Biomarkers may be detected in a specific location or tissue or in plasma and other bodily fluids.<a href="/en-us/applications-technologies/biomarker-discovery"><strong><br /></strong></a></p> </td> </tr> <tr> <td align="left" valign="top"> <p><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/biochemical-and-cellular-assays.jpg" alt="Biochemical and Cellular Assays" /></p> </td> <td align="left" valign="top"> <p><a href="/en-us/applications-technologies/biochemical-cellular-assays"><strong>Biochemical and Cellular Assays</strong></a><br />Biochemical and cellular pharmacology teams develop and validate assays to support research across drug discovery and development. These assays range from discovery approaches with high sample throughput to high-content analysis to gain an understanding of biological response both in vitro and in vivo.<a href="/en-us/applications-technologies/biochemical-cellular-assays"><strong><br /></strong></a></p> </td> </tr> </tbody> </table> Karen Moss Preclinical Research Learn about preclinical research in drug discovery & development. drug discovery, discovery, drug development, development, pharma, pharmaceutical, preclinical research, preclinical trials 10/06/15 02:45 PM 10/06/25 02:49 PM AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA en LSR /LSR/Applications/Drug_Discovery N 0
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