Biomarker Discovery

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Overview

Biomarker Discovery

 

The use of biomarkers across drug discovery and development and into the clinic is key to enabling close monitoring of a drug candidate’s effects. Biomarkers can range from specific molecules such as a protein, a gene sequence, or expressed RNA to more physiological parameters such as blood pressure. Biomarkers may be expressed in a specific location or tissue or found in serum, plasma, and other bodily fluids. Show more

Biomarkers are used in research to design and develop more effective therapeutics, to assist in guiding decisions about which candidates to develop further, as surrogate markers for the selection of patients, and as endpoints for both benefits and risks. There are a wide range of types of biomarkers that can be monitored, such as predictive, prognostic, pharmacodynamic, safety, and efficacy markers. One class of biomarkers that is actively being researched is safety biomarkers. These markers are being developed to help determine which drug candidates are most likely to be safely tolerated in humans.

Validation of biomarkers requires that their levels change in response to a disease, condition, or other parameter in a consistent and statistically significant manner. Identification and characterization of biomarkers can reduce the number of candidate drugs that fail clinical trials, aid in the discovery of more effective therapeutics, and provide methods for monitoring animals in preclinical research and evaluating the response of human participants in clinical trials. Show less

 

Cell Sorting for Drug DiscoveryFeatured Video
Automated, Affordable Cell Sorting for Drug Discovery & Development with the S3e™ Cell Sorter

 


Solutions for Biomarker Discovery

Gene Expression

Gene Expression

Select from a range of validated PCR, qPCR, and digital PCR instruments to incorporate into your biomarker research. Explore our large library of disease-specific and pathway-specific predesigned PCR primers, probes, and assay panels that meet MIQE guidelines, or order custom-designed primers and plates.

Droplet Digital™ PCR Systems
ddPCR™ Supermixes for Residual DNA Quantification

PCR Instrument Validation Tools and Services

 

Protein Expression, Quantitation, and Analysis

Protein Expression, Quantitation, and Analysis

Analyze the expression of biomarkers in complex backgrounds with multiplex immunoassays, 1-D and 2-D electrophoresis, and western blotting.

Multiplex Cell Signaling Immunoassays
Multiplex Cancer Biomarker Immunoassays
Multiplex Kidney Toxicity Immunoassays
Custom Multiplex Immunoassays
2-D Electrophoresis Systems
Stain-Free Gel and Western Blot Imaging Systems

Cell Analysis

Cell Analysis

Bio-Rad offers equipment and reagents for cell-based biomarker evaluation and measurement.

Cell Sorting and Flow Cytometry
Antibodies for Flow Cytometry
Cell Imaging
Cell Counting

Antibodies

Antibodies

Choose from an extensive range of antibodies for biomarker discovery assays, or utilize our custom antibody services and create your own.

Antibodies by Application
Antibodies for Diagnostic Assay Development
Antibodies for Drug Discovery and Development
HuCAL® Custom Antibody Services

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