The use of biomarkers across drug discovery and development and into the clinic is key to enabling close monitoring of a drug candidate’s effects. Biomarkers can range from specific molecules such as a protein, a gene sequence, or expressed RNA to more physiological parameters such as blood pressure. Biomarkers may be expressed in a specific location or tissue or found in serum, plasma, and other bodily fluids. Show more
Biomarkers are used in research to design and develop more effective therapeutics, to assist in guiding decisions about which candidates to develop further, as surrogate markers for the selection of patients, and as endpoints for both benefits and risks. There are a wide range of types of biomarkers that can be monitored, such as predictive, prognostic, pharmacodynamic, safety, and efficacy markers. One class of biomarkers that is actively being researched is safety biomarkers. These markers are being developed to help determine which drug candidates are most likely to be safely tolerated in humans.
Validation of biomarkers requires that their levels change in response to a disease, condition, or other parameter in a consistent and statistically significant manner. Identification and characterization of biomarkers can reduce the number of candidate drugs that fail clinical trials, aid in the discovery of more effective therapeutics, and provide methods for monitoring animals in preclinical research and evaluating the response of human participants in clinical trials. Show less
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Select from a range of validated PCR, qPCR, and digital PCR instruments to incorporate into your biomarker research. Explore our large library of disease-specific and pathway-specific predesigned PCR primers, probes, and assay panels that meet MIQE guidelines, or order custom-designed primers and plates.
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