Biologic Development

Print

Overview

Consult with an Specialist

Have Questions About Biologic Development?

Consult with a Specialist

Medicines called biologics are transforming the healthcare landscape by offering patients with hard-to-treat conditions a real benefit. Biologics are part of a wave of more targeted therapies that are being developed as drug makers move towards a personalized medicine approach in treating disease.

Novel Therapeutics Called Biologics

Biologics are not a new class of drugs, as biological drugs such as insulin have been available for decades. However, in recent years the number of biological drugs available to patients and the diseases that they treat have grown tremendously. Our increased understanding of the underlying biological processes that inform human health and the changes that happen during disease or chronic illness have helped spur the development of novel biological drugs targeted to provide treatment and relief for patients.1

Biologics are large complex molecules consisting of a combination of proteins, peptides, nucleic acids, sugars, or other cellular structures, produced within living cells The shifting focus toward biological drug products results in targeted treatments that have mechanisms of action previously unavailable from existing small molecule drugs.

Both small and large molecule drugs interact with a patient's biology; however, small molecule drugs often work as inhibitors disrupting a process ordinarily associated with a particular disease. Small molecules have the ability to penetrate cells, with the potential for off-target interactions that can cause side effects. Large biologic drugs, in contrast, are designed to bind with extreme precision to specific targets and in doing so can target molecular processes that small molecule drugs cannot.

Focus on Monoclonal Antibodies

Monoclonal antibody (mAb) biological drugs are the most commonly developed when compared to other biological drug types, such as proteins, enzymes, and vaccines. In terms of approvals for novel medicines, biological drugs have grown to comprise approximately one-third of all new medicines approved by the US FDA.2 In addition, more than half the drugs currently in development by pharma and biotech companies are biologics.

Novel biological drugs targeted towards cancer treatment receive the most R&D funding with rare diseases, autoimmune disorders and neurological disorders, occupying the next three spots.3 In addition to an increase in spending on R&D for biological drugs, supportive government initiatives and demand for personalized medicines are contributing to the expectation that the global market size for mAbs will continue to rise over the next several years.

Manufacturing Monoclonal Antibodies

The production of a biological drug is dependent upon a manufacturing process which is time consuming, challenging, expensive, and often complicated. The development of the manufacturing process for a biologic includes genetically engineering a cell to produce the biologic, multiple steps for purification of the biologic through chromatography resins, and associated testing throughout to ensure product quality, purity, and stability.4 The active component of the biologic drug, often a portion or modification of the original protein or polypeptide may not be clearly characterized. Because of the heterogeneous nature of the molecule, the biologic can have an impurity profile that varies with the manufacturing and testing process utilized.

Explore a wide variety of research solutions to accelerate your biologic development. Included are workflow options, applications, technical information, protocols, instruments, and more.

References

1 Morrow T (2004). Defining the Difference: What Makes Biologics Unique, Biotechnology Healthcare, pp. 24-29.

2 Gottleib S. Capturing the Benefits of Competition for Patients

3 Hooven M (2017). Opportunities and Challenges in Biologic Drug Delivery, Am Pharmaceutical Review, posted 22 Dec 2017.

4 Jallal, B. Realizing the Promise of Biologics

 
 
Page Contents
 
 
 
PNI7JRTU86LJ [x-forwarded-proto] = [http] [accept-language] = [en-US,en;q=0.5] [x-forwarded-port] = [80] [x-forwarded-for] = [3.84.130.252, 10.232.2.162] [accept] = [text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8] [seourl] = [/en-us/applications-technologies/biologic-development] [x-amzn-trace-id] = [Root=1-5d09fe27-2f07dcd6ddf61ce81ab0f478] [x-forwarded-server] = [lsds-prod-s.br.aws-livesite.io] [x-forwarded-host] = [www.bio-rad.com] [x-query-string] = [ID=PNI7JRTU86LJ] [host] = [10.232.0.21:1776] [x-request-uri] = [/en-us/applications-technologies/biologic-development] [connection] = [Keep-Alive] [accept-encoding] = [gzip] [user-agent] = [CCBot/2.0 (https://commoncrawl.org/faq/)] AppTech/AppTechDetails pageStyleKey internet/solutions_sub applications-technologies/biologic-development LSR PNI7JRTU86LJ Biological Development Biologic Development /webroot/web/images/lsr/solutions/applications/drug_discovery/biologic-development-th.jpg <div class="pagenav"><img src="/webroot/web/images/opt/prodnav-arrow-top.png" alt="" /> <table border="0"> <tbody> <tr> <td class="pagenavhead"> <h3>On This Page</h3> </td> <td class="pagenavfirst"><!---<a onmousedown="dcsMultiTrack('DCS.dcsqry','?tgp_pcp_link_group=Page Nav&amp;tgp_pcp_link=Legalization in USA and Canada - 2019','DCSext.tgp_pcp_link_group','','DCSext.tgp_pcp_link','','WT.dl','99999');" href="#legal">Legalization in USA and Canada - 2019</span></a>---><a onmousedown="dcsMultiTrack('DCS.dcsqry','?tgp_pcp_link_group=Page Nav&amp;tgp_pcp_link=Novel Therapeutics Called Biologics','DCSext.tgp_pcp_link_group','','DCSext.tgp_pcp_link','','WT.dl','99999');" href="#novel">Novel Therapeutics Called Biologics</a></td> <td><a onmousedown="dcsMultiTrack('DCS.dcsqry','?tgp_pcp_link_group=Page Nav&amp;tgp_pcp_link=Focus on Monoclonal Antibodies','DCSext.tgp_pcp_link_group','','DCSext.tgp_pcp_link','','WT.dl','99999');" href="#focus">Focus on Monoclonal Antibodies</a></td> <!---<td><a onmousedown="dcsMultiTrack('DCS.dcsqry','?tgp_pcp_link_group=Page Nav&amp;tgp_pcp_link=Protocol','DCSext.tgp_pcp_link_group','','DCSext.tgp_pcp_link','','WT.dl','99999');" href="#protocol">Manufacturing Monoclonal Antibodies</a></td>---> <td><a onmousedown="dcsMultiTrack('DCS.dcsqry','?tgp_pcp_link_group=Page Nav&amp;tgp_pcp_link=Drug Discovery and Development,'DCSext.tgp_pcp_link_group','','DCSext.tgp_pcp_link','','WT.dl','99999');" href="#ddd">Drug Discovery and Development</a></td> <td><a onmousedown="dcsMultiTrack('DCS.dcsqry','?tgp_pcp_link_group=Page Nav&amp;tgp_pcp_link=References,'DCSext.tgp_pcp_link_group','','DCSext.tgp_pcp_link','','WT.dl','99999');" href="#references">References</a></td> <td class="pagenavlast"><a onmousedown="dcsMultiTrack('DCS.dcsqry','?tgp_pcp_link_group=Page Nav&amp;tgp_pcp_link=Resources,'DCSext.tgp_pcp_link_group','','DCSext.tgp_pcp_link','','WT.dl','99999');" href="#resources">Resources</a></td> </tr> </tbody> </table> </div> <div class="opt-module opt-module-first opt-module-noborder"> <div class="corner-box corner-box-promo no-bttm-margin linkpointer-blank"><img src="/webroot/web/images/general/global/english/have-questions-icon.png" border="0" alt="Consult with an Specialist" style="width: 60px; height: auto;" /> <h2>Have Questions About Biologic Development?</h2> <a href="/en-us/category/biologic-development?ID=PPS1WVWDLBV5" class="bttn-block no-target-style" target="_blank" rel="noopener noreferrer"><span class="bttn-orange">Consult with a Specialist</span></a></div> <p>Medicines called biologics are transforming the healthcare landscape by offering patients with hard-to-treat conditions a real benefit. Biologics are part of a wave of more targeted therapies that are being developed as drug makers move towards a personalized medicine approach in treating disease.</p> </div> <div><a name="novel"></a></div> <div class="opt-module opt-module-biologics-background opt-module-noborder"> <h2 class="nextp">Novel Therapeutics Called Biologics</h2> <p>Biologics are not a new class of drugs, as biological drugs such as insulin have been available for decades. However, in recent years the number of biological drugs available to patients and the diseases that they treat have grown tremendously. Our increased understanding of the underlying biological processes that inform human health and the changes that happen during disease or chronic illness have helped spur the development of novel biological drugs targeted to provide treatment and relief for patients.<sup>1</sup></p> <p>Biologics are large complex molecules consisting of a combination of proteins, peptides, nucleic acids, sugars, or other cellular structures, produced within living cells The shifting focus toward biological drug products results in targeted treatments that have mechanisms of action previously unavailable from existing small molecule drugs.</p> <p>Both small and large molecule drugs interact with a patient's biology; however, small molecule drugs often work as inhibitors disrupting a process ordinarily associated with a particular disease. Small molecules have the ability to penetrate cells, with the potential for off-target interactions that can cause side effects. Large biologic drugs, in contrast, are designed to bind with extreme precision to specific targets and in doing so can target molecular processes that small molecule drugs cannot.</p> </div> <div><a name="focus"></a></div> <div class="opt-module opt-module-biologics-monoclonal-igg-background"> <h2 class="nextp">Focus on Monoclonal Antibodies</h2> <!---<img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/monoclonal-antibodies-bottles-opt.png" class="right bottles" alt="" />---> <p>Monoclonal antibody (mAb) biological drugs are the most commonly developed when compared to other biological drug types, such as proteins, enzymes, and vaccines. In terms of approvals for novel medicines, biological drugs have grown to comprise approximately one-third of all new medicines approved by the US FDA.<sup>2</sup> In addition, more than half the drugs currently in development by pharma and biotech companies are biologics.</p> <p>Novel biological drugs targeted towards cancer treatment receive the most R&amp;D funding with rare diseases, autoimmune disorders and neurological disorders, occupying the next three spots.<sup>3</sup> In addition to an increase in spending on R&amp;D for biological drugs, supportive government initiatives and demand for personalized medicines are contributing to the expectation that the global market size for mAbs will continue to rise over the next several years.</p> <h3 class="opt-subhead30">Manufacturing Monoclonal Antibodies</h3> <img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/monoclonal-antibodies-blueprint-opt.png" class="left blueprint" alt="" /> <p>The production of a biological drug is dependent upon a manufacturing process which is time consuming, challenging, expensive, and often complicated. The development of the manufacturing process for a biologic includes genetically engineering a cell to produce the biologic, multiple steps for purification of the biologic through chromatography resins, and associated testing throughout to ensure product quality, purity, and stability.<sup>4</sup> The active component of the biologic drug, often a portion or modification of the original protein or polypeptide may not be clearly characterized. Because of the heterogeneous nature of the molecule, the biologic can have an impurity profile that varies with the manufacturing and testing process utilized.</p> <p>Explore a wide variety of research solutions to accelerate your biologic development. Included are workflow options, applications, technical information, protocols, instruments, and more.</p> </div> <div><a name="ddd"></a></div> <div class="opt-module opt-module-biologics-featured-drug-discovery-development"> <h2 class="nextp">Drug Discovery and Development</h2> <p>Bio-Rad offers products and services to accelerate the drug discovery and development journey, from target identification through scale-up to manufacturing.</p> <p><a class="bttn-block no-target-style" href="/en-us/applications-technologies/drug-discovery-development?ID=NU4EE515"><span class="bttn-orange">Accelerate Your Biologic Development</span></a></p> </div> <div><a name="references"></a></div> <div class="opt-module opt-module-noborder"> <h2 class="nextp">References</h2> <p class="sup-list"><sup>1</sup>&nbsp;Morrow T (2004). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564302/" target="_blank" rel="noopener noreferrer">Defining the Difference: What Makes Biologics Unique</a>, Biotechnology Healthcare, pp. 24-29.</p> <p class="sup-list"><sup>2</sup>&nbsp;Gottleib S. <a href="https://www.fda.gov/NewsEvents/Speeches/ucm599833.htm" target="_blank" rel="noopener noreferrer">Capturing the Benefits of Competition for Patients</a></p> <p class="sup-list"><sup>3</sup>&nbsp;Hooven M (2017). <a href="https://www.americanpharmaceuticalreview.com/Featured-Articles/345540-Opportunities-and-Challenges-in-Biologic-Drug-Delivery/" target="_blank" rel="noopener noreferrer">Opportunities and Challenges in Biologic Drug Delivery</a>, Am Pharmaceutical Review, posted 22 Dec 2017.</p> <p class="sup-list"><sup>4</sup>&nbsp;Jallal, B. <a href="http://www.hhpronline.org/articles/2017/4/9/realizing-the-promise-of-biologics" target="_blank" rel="noopener noreferrer">Realizing the Promise of Biologics</a></p> </div> <div><a name="resources"></a></div> <div class="opt-module optresources-bg"> <h2>Resources</h2> <ul class="list-set list-three-col list-set-th"> <li><a href="/webroot/web/pdf/lsr/literature/Bulletin_6877.pdf" target="_blank" rel="noopener noreferrer"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/drug-discovery-workflow-th.png" alt="" /></a> <h3><a href="/webroot/web/pdf/lsr/literature/Bulletin_6877.pdf" target="_blank" rel="noopener noreferrer">Bio-Rad's Drug Discovery and Development Workflow Solutions</a></h3> <p><span class="filesize">(PDF 2.2 MB)</span><br /><br /></p> </li> <li><a href="/webroot/web/pdf/fsd/literature/Bulletin_16439.pdf" target="_blank" rel="noopener noreferrer" class="no-target-style"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/biologics-workflow-doc-th.png" alt="iQ-Check Real-Time PCR Solution Brochure" /></a> <h3><a href="/webroot/web/pdf/lsr/literature/Bulletin_6385.pdf" target="_blank" rel="noopener noreferrer" class="no-target-style">BioLogics Workflow Solutions</a></h3> <p><span class="filesize">(PDF 3 MB)</span><br /><br /></p> </li> <li><a href="/webroot/web/pdf/lsr/literature/Bulletin_7181.pdf" target="_blank" rel="noopener noreferrer"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/7181.png" alt="" /></a> <h3><a href="/webroot/web/pdf/lsr/literature/Bulletin_7181.pdf" target="_blank" rel="noopener noreferrer">Changing the Treatment Landscape with the Development of Biologics</a></h3> <p><span class="filesize">(PDF 245 KB)</span><br /><br /></p> </li> </ul> <script type="text/javascript" src="/webroot/web/js/apptech-opt-conveter-min.js"></script> </div> Jessica Low Biologic Development Biologic development brings patients closer to personalized medicine to treat health problems. biologic development, personalized healthcare, drug discovery, 7181 02/27/19 12:59 AM 12/10/29 12:55 AM AR,BO,BR,CA,CL,CO,CR,DO,EC,SV,GU,GT,HT,HN,JM,MX,NI,PA,PY,PE,PR,TT,US,UY,VE,AU,BD,BN,KH,CN,HK,IN,ID,JP,KR,MO,MY,FM,NP,NZ,PW,PG,PH,SG,SB,LK,TW,TH,TO,VU,AL,DZ,AI,AM,AT,AZ,BH,BE,BA,BW,BG,BF,CM,HR,CY,CZ,DK,EG,ER,EE,ET,FO,FI,FR,GF,PF,GA,GE,DE,GH,GR,GP,HU,IS,IE,IL,IT,JO,KZ,KE,XK,KW,LV,LB,LI,LT,LU,MK,MG,ML,MT,MQ,MU,MD,MS,MA,NL,NG,NO,OM,PK,PS,PL,PT,QA,RO,RU,ST,SA,SN,RS,SK,SI,ZA,ES,SE,CH,TZ,TG,TN,TR,UG,UA,AE,UK,UZ,VA,EH,YE,VN LSR /LSR/Applications/Drug_Discovery/Biologics_Discovery N 0
Sign Up for Bio-Rad Updates!
Enter your email address below to receive your choice of the latest news, promotions, and more.
PNI7JRTU86LJ [x-forwarded-proto] = [http] [accept-language] = [en-US,en;q=0.5] [x-forwarded-port] = [80] [x-forwarded-for] = [3.84.130.252, 10.232.2.162] [accept] = [text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8] [seourl] = [/en-us/applications-technologies/biologic-development] [x-amzn-trace-id] = [Root=1-5d09fe27-2f07dcd6ddf61ce81ab0f478] [x-forwarded-server] = [lsds-prod-s.br.aws-livesite.io] [x-forwarded-host] = [www.bio-rad.com] [x-query-string] = [ID=PNI7JRTU86LJ] [host] = [10.232.0.21:1776] [x-request-uri] = [/en-us/applications-technologies/biologic-development] [connection] = [Keep-Alive] [accept-encoding] = [gzip] [user-agent] = [CCBot/2.0 (https://commoncrawl.org/faq/)] AppTech/AppTechDetails pageStyleKey applications-technologies/biologic-development LSR 03/26/14 02:17 PM en_US true internet/generic 2018-12-28 22:30:28 /default/main/bio-rad/STAGING 1385504243813 US templatedata/internet/generic/data/en_US/GNL/page_generic_footer_b2c_1385505294_US.xml page_generic_footer_b2c /default/main/bio-rad/WORKAREA/default jc7v8okm 2017-10-27 13:13:40 true Done jc7v8okm templatedata/internet/generic/data/en_US/GNL/page_generic_footer_b2c_1385505294_US.xml GNL N /default/main/bio-rad en_US 11/27/23 02:18 PM 1539210190090 2018-12-28 22:30:28 /default/main/bio-rad/WORKAREA/default/templatedata/internet/generic/data/en_US/GNL/page_generic_footer_b2c_1385505294_US.xml footer-page 1 1385504243813 page_generic_footer_b2c <div class="links"> <h4>Support</h4> <ul> <li><a class="msdsLink wtclass linkgeneration" href="/_locale/literature-library">MSDS</a></li> <li><a class="cofaLink wtclass linkgeneration" href="/_locale/_defaultVerticalUrl/support/certificate-of-analysis">Certificate of Analysis</a></li> <li><a class="qcinsertsLink wtclass" href="http://myeinserts.qcnet.com/" target="_blank" rel="noopener noreferrer">QC Inserts</a></li> <li><a class="technicalsupportLink wtclass linkgeneration" href="/_locale/life-science-research/support">Technical Support<br />For Life Science</a></li> <li><a class="expertCSLink wtclass linkgeneration" href="/_locale/_defaultVerticalUrl/purchase-service-programs/expert-care-service?ID=1383780912356">Expert Care Service</a></li> <li><a class="feedBackLink wtclass linkgeneration" id="feedbackID" href="javascript:void(0)">Feedback</a></li> <li><a class="contactUSLink wtclass linkgeneration" href="/_locale/contact-us">Contact Us</a></li> </ul> </div> <div class="links"> <h4>Ordering</h4> <ul> <li><a id="quickOrderLink" class="quickOrderLink wtclass" name="quickOrderLink" href="javascript:openAjaxOverlay('/evportal/portlets/ordering/quickOrderOverlayContent.jsp?quickorder_location=Footer')">Quick Order</a></li> <li><a class="mybioradLink wtclass linkgeneration" href="/_locale/my-bio-rad">My Bio-Rad</a></li> <li><a id="footer_orderLink" class="orderhistoryLink wtclass" href="javascript:void(0);">Order History</a></li> <li><a id="footer_quoteLink" href="javascript:void(0);">Quote History</a></li> <li><a class="supplycentersLink wtclass linkgeneration" href="/_locale/_defaultVerticalUrl/purchase-service-programs/supply-center-program">Supply Centers</a></li> <li><a class="returnpolicyLink wtclass linkgeneration" href="javascript:openAjaxOverlay('/webroot/web/html/returnPolicy-us.html','Return and Refund Policy');">Return and Refund Policy</a></li> </ul> </div> <div class="links"> <h4>Our Products</h4> <ul> <li><a class="lsrLink wtclass linkgeneration" href="/_locale/life-science-research">Life Science Research</a></li> <li><a class="cdLink wtclass linkgeneration" href="/_locale/clinical-diagnostics">Clinical Diagnostics</a></li> <li><a class="infLink wtclass linkgeneration" href="/_locale/spectroscopy">Spectroscopy</a></li> <li><a class="psLink wtclass linkgeneration" href="/_locale/process-separations">Process Separations</a></li> <li><a class="fsLink wtclass linkgeneration" href="/_locale/food-science">Food Science</a></li> <li><a class="lseLink wtclass linkgeneration" href="/_locale/education">Life Science Education</a></li> <li><a class="selectionguideLink wtclass linkgeneration" href="/featured/en/selection-guides.html">Selection Guides</a></li> <li><a class="featuredproductsLink wtclass" href="/featured/en/featured-products.html">Featured Products</a></li> </ul> </div> <div class="links links2"> <h4>Corporate</h4> <ul> <li><a class="aboutbioradLink wtclass linkgeneration" href="/_locale/corporate/about-bio-rad">About Bio-Rad</a></li> <li><a class="careersLink wtclass linkgeneration" href="/_locale/corporate/careers">Careers</a></li> <li><a class="irLink wtclass linkgeneration" href="/_locale/corporate/investor-relations">Investor Relations</a></li> <li><a class="coLink wtclass linkgeneration" href="/_locale/corporate/community-outreach">Community Outreach</a></li> <li><a class="pteLink wtclass linkgeneration" href="/_locale/corporate/protecting-environment">Protecting the Environment</a></li> <li><a class="newsroomLink wtclass linkgeneration" href="/_locale/corporate/newsroom">Newsroom</a></li> </ul> </div> <p> <script type="text/javascript">// <![CDATA[ $(document).ready(function(){ var feedbackOverlayUrl = '/bio-rad/Standalone/FeedbackOverlay.page?standalonePage=true'; $("#feedbackID").click(function(){ openAjaxOverlay(feedbackOverlayUrl,"Feedback"); }); }); // ]]></script> <script type="text/javascript">// <![CDATA[ if($.cookie('evCntryLang')){ (function(){"use strict";var e=null,b="4.0.0", n="10740", additional="", t,r,i;try{t=top.document.referer!==""?encodeURIComponent(top.document.referrer.substring(0,2048)):""}catch(o){t=document.referrer!==null?document.referrer.toString().substring(0,2048):""}try{r=window&&window.top&&document.location&&window.top.location===document.location?document.location:window&&window.top&&window.top.location&&""!==window.top.location?window.top.location:document.location}catch(u){r=document.location}try{i=parent.location.href!==""?encodeURIComponent(parent.location.href.toString().substring(0,2048)):""}catch(a){try{i=r!==null?encodeURIComponent(r.toString().substring(0,2048)):""}catch(f){i=""}}var l,c=document.createElement("script"),h=null,p=document.getElementsByTagName("script"),d=Number(p.length)-1,v=document.getElementsByTagName("script")[d];if(typeof l==="undefined"){l=Math.floor(Math.random()*1e17)}h="dx.steelhousemedia.com/spx?"+"dxver="+b+"&shaid="+n+"&tdr="+t+"&plh="+i+"&cb="+l+additional;c.type="text/javascript";c.src=("https:"===document.location.protocol?"https://":"http://")+h;v.parentNode.insertBefore(c,v)})() } // ]]></script> </p> /webroot/web/html footer_page_b2c_en_US.html /webroot/web/html/footer_page_b2c_en_US.html Karen Moss Footer page Footer 03/26/14 02:17 PM 11/27/23 02:18 PM US en GNL /GNL N 0 en-us Home <script type="text/javascript">$(document).ready(function() { $(".footer-nav > a:nth-child(3)").after(" | <a href='javascript:void(0)' id='regionlink'>Web Accessibility</a>"); var region = $("#headlangID .lang strong").html(); $("#regionlink").click(function(){ window.location.replace( "/webroot/web/html/featured/en/web-accessibility.html?Region=" + region );});});</script>Trademarks Site Terms Terms & Conditions Imprint EU Recycle Program Privacy Change Cookie Setting <script type="text/javascript">$(document).ready(function () {$(".links2").append('<style>.social-links-br {float: left;margin-right: 10px;}.social-links-br img {width: 20px;height: 20px;margin-right: 5px}</style><div class="social-links-br"><a class="no-target-style" href="https://www.linkedin.com/company/bio-rad?trk=top_nav_home" target="_blank"><img src="/webroot/web/images/general/icons/linkedin_round_40x40.png" alt="Bio-Rad LinkedIn"></a><a class="no-target-style" href="https://www.youtube.com/user/BioRadLifeScience" target="_blank"><img src="/webroot/web/images/general/icons/youtube-icon-rnd-40x40.png" alt="Bio-Rad YouTube"></a><a class="no-target-style" href="https://twitter.com/BioRadLifeSci" target="_blank"><img src="/webroot/web/images/general/icons/twitter_round_40x40.png" alt="Bio-Rad Twitter"></a><a class="no-target-style" href="https://www.facebook.com/biorad/" target="_blank"><img src="/webroot/web/images/general/icons/facebook-icon-rnd-40x40.png" alt="Bio-Rad Facebook"></a><a class="no-target-style" href="https://www.instagram.com/bioradlabs/" target="_blank"><img src="/webroot/web/images/general/icons/instagram-icon-rnd-40x40.png" alt="Bio-Rad Instagram"></a></div>');});</script>Copyright &copy; {0} Bio-Rad Laboratories, Inc. All rights reserved. This page was last edited on {0} true True GTM-MJ2DN2S us US en LSR life-science-research life-science-research /prd/en/US/direct/biorad?ts=1&cmd=OrdersWorkspaceDisplay /prd/en/US/direct/biorad?ts=1&cmd=QuotesWorkspaceDisplay /prd/en/US/direct/biorad?ts=1&cmd=InvoiceWorkspaceDisplay&_Tab=Invoice false false true false true true 1040988879 LHsYCOu_wQMQz_Ww8AM window.google_tag_params true 272-THL-329 username CartID_ WT_FPC <script type="text/javascript">$.ajax({url: document.location.protocol + '//munchkin.marketo.net/munchkin.js',dataType: 'script',cache: true,success: function() {Munchkin.init('044-CBN-599');}});</script> <script type="text/javascript" src="/evportal/framework/skins/evolution/js/proxyMunchkin.js"></script> 2019