Leverage Our Novel Resins and Proven Expertise
Delivering more than just resins, at Bio-Rad you’ll find robust solutions for challenging purifications by working with our experienced monoclonal antibody purification support scientists.
While most monoclonal antibody (mAb) purification for process development begins with Protein A, you will often need intermediate and polishing steps to achieve full separation of your therapeutic from host cell proteins (HCPs), aggregates, and other contaminants.
At Bio-Rad, you will find a full range of quality resins that can take you from process development into manufacturing. Even better, you will also find a team of experienced bioprocess scientists ready to help you overcome any purification challenges. Whether you are purifying a monoclonal antibody, bispecific antibody, an antibody-drug conjugate, or any antibody format, you will find our selection of unique selectivity resins will meet your biomolecule purification needs.
Did you know?
The first proteins were described in 1789 by the French chemist Antoine Fourcroy, a contemporary of Antoine Lavoisier. Fourcroy described albumin, fibrin, and gelatin.1
Find a Resin for Every Stage of Purification
If you are wanting to move away from Protein A and want an alternative like ion exchange, you will find an effective resin for your purification development.
When your goal is to remove impurities like HCPs and aggregates, you are most likely looking for an ion exchange resin. We offer anion and cation exchange resins that offer high productivity and the ability to maintain performance after multiple cleaning-in-place (CIP) cycles.
Ion exchange chromatography is a great choice for removing closely related molecules and mixed-mode resins can effectively purify with high yield and achieve purity in a two-step purification workflow. Our mixed-mode library includes CHT, a cationic metal affinity resin, Nuvia cPrime, a hydrophobic cationic exchange resin, and Nuvia aPrime 4A, a hydrophobic anionic exchange resin.
Our team of purification scientists is available to assist you with method and process development. Request a custom seminar to discuss your purification needs with our experienced scientists.
Browse a collection of resources, including resin information and sample request, technical videos and tutorials, application notes, and strategy guides to help with your purification success, from development to commercialization.
Learn how to select optimal chromatography resins for monoclonal antibody (mAb) purification with our handy guide.
Discover how mixed-mode approaches can streamline your purification workflow, increase efficiency and recovery of antibodies.
Learn why biopharma has turned to prepacked chromatography columns and their benefits to biotherapeutic manufacturing.
Learn how process economics is improved more than fourfold for biosimilar production with an ion exchange and mixed-mode purification workflow.
Learn how an optimized hydrophobic anion-exchange (AEX) mixed-mode resin can enable exceptional purification and recovery of monoclonal antibodies.
Optimize your antibody purification strategy with our antibody purification guide for selecting resins ideal for capture, intermediate, and polish.
Learn how a two-step mixed-mode chromatography approach can simplify antibody purification without compromising purity or yield.
- Tanford C, Reynolds J. Nature’s Robots: A History of Proteins. OUP Oxford; 2003. https://books.google.com/books?id=Vg5H7InfABEC
Ready to learn how Bio-Rad can accelerate your method and process development for monoclonal antibody purification? Our scientists are here to help.
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