- Target
Discovery - Lead
Discovery - Preclinical
Research - Clinical
Research - Process
Development - Manufacturing
and Testing
The required production quantities of a candidate drug molecule increase greatly as the development cycle moves from discovery through development to approval and large-scale manufacturing. Design and optimization of production scale-up (including pilot plant operations), also known as process development, requires careful testing and monitoring using a wide range of different techniques including protein purification, analysis, quantitation, and identification tools at every step. Show more
One field of active research is to determine how small-scale models can be used to both design scale-up procedures and permit more rapid testing and optimization of process development. This is called scale-down, and provides greater flexibility for testing multiple parameters, more rapid system characterization, and iterative improvements. Furthermore, scale-down can be used for validation purposes. In addition to saving time, scale-down can significantly reduce costs. Sensitive analytical techniques are required for accurate evaluation of scale-down. Show less
Page Contents
Gene ExpressionDetect and quantitate nucleic acids in your scale-up/scale-down batches. Identify and measure any copurifying residual host cell DNA. Droplet Digital™ PCR Systems
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Protein PurificationDevelop and finesse protein purification strategies across process development and scale-up using our extensive range of chromatography resins and instrumentation. NGC™ Medium-Pressure Chromatography Systems with IQ/OQ and CFR-Compliant Software |
Protein AnalysisUse our comprehensive protein analysis tools to monitor protein profiles throughout scale-up and validate antibodies used to detect and identify contaminating host cell proteins (HCP). Western Blotting Reagents and Equipment |
AntibodiesSave process development time with a wide selection of off-the-shelf antibodies. Utilize our custom antibody services for more specific antibody requirements, including for assay manufacturing purposes. Antibodies by Application |
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Biochemical and Cellular Assays
In vitro and in vivo discovery approaches with high sample throughput and high-content analysis to characterize biological responses. -
Biomarker Discovery & Validation
Biomarker monitoring across drug discovery, development, and clinical stages is key to defining drug effects. -
Biologic Development
Biologic development brings patients closer to personalized medicine to treat health problems. -
Biosimilar Development
Biosimilar development requires physicochemical and functional characterization to ensure similarity. -
Cancer Immunotherapy Development
Learn about trends in cancer immunotherapy development, such as CAR-T, and tools for genomic, cellular, and proteomic research. -
CRISPR Gene Editing
CRISPR enables researchers to edit their desired target genes efficiently and accelerate drug development. -
Viral Vector Vaccine Development
The COVID-19 pandemic opened the door to expedited vaccine development using new technologies and therapies that have traditionally been used in other applications.