Bio-Plex Pro Human IgG SARS-CoV-2 N/RBD/S1/S2 4-Plex Panel #12014634



1 x 96-well, includes magnetic capture beads coupled with SARS-CoV-2 nucleocapsid, receptor-binding domain, spike 1, and spike 2 viral proteins, anti-human IgG detection antibody, ready-to-use positive control, ready-to-use negative control, wash buffer, assay buffer, serology sample diluent, detection antibody diluent, streptavidin-PE, 96-well flat-bottom plate, and sealing tape.

Safety Data Sheet

Safety Data Sheet



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The Bio-Plex Pro Human IgG SARS-CoV-2 S1/S2/N/RBD 4-Plex Panel detects IgG antibodies against SARS-CoV-2 nucleocapsid, receptor-binding domain, spike 1, and spike 2 viral proteins. Measuring antibodies against each SARS-CoV-2 viral protein enables researchers to study the immune response to natural infection, vaccination, and levels of exposure in populations.

Features and Benefits

  • Comprehensive panel coverage — detects antibody response to four highly relevant SARS-CoV-2 viral proteins in a single well
  • High specificity and sensitivity  builds greater confidence in a positive or negative assessment in samples for seroprevalence studies
  • Fast protocol — results in less than 3 hours
  • Reproducibility — attain consistent results in your experiments with a robust, magnetic bead-based workflow
  • Streamlined data analysis — manage and analyze your data with ease using Bio-Plex Manager and Bio-Plex Data Pro Software

Kit Components

  • Magnetic capture beads coupled with SARS-CoV-2 viral proteins:
    • Nucleocapsid protein
    • Receptor-binding domain (RBD) protein
    • Spike 1 protein
    • Spike 2 protein
  • Anti-human IgG detection antibody
  • Ready-to-use positive and negative controls
  • Wash buffer and assay buffer
  • Sample and detection antibody diluents
  • Streptavidin-PE
  • 96-well flat-bottom plate and sealing tape

Individual kit components can also be purchased to create custom assays.

Instrument Compatibility

Compatible with all xMAP Platforms:

*For Research Use Only. Not for use in diagnostic procedures.



Reactive species
Intra-assay precision, %CV
Inter-assay precision, %CV
Clinical specificity
(n = 282 negative samples)

N = 99%, RBD = 96%, S1 = 99%, and S2 = 95%
Clinical sensitivity
(n=65 SARS-CoV-2 positive samples)

N = 100%, RBD = 100%, S1 = 98%, and S2 = 100%
Compatible sample matrices
Serum, plasma



Number Description Options
Bio-Plex Pro Human SARS-CoV-2 Serology Assays Instruction Manual
Bio-Plex Pro SARS-CoV-2 Serology Assay Quick Guide
Quantitative Bio-Plex Pro Human IgG, IgA, and IgM SARS-CoV-2 Serology Assays Using a Standard Curve Application Note
Bio-Plex Pro Human IgA, IgG, and IgM SARS-CoV-2 Serology Assay Performance in Freeze-Thawed and Refrigerated Serum, Plasma, and Saliva Samples
Calibration Factors Using WHO International Standard (NIBSC 20/136) for Anti–SARS-CoV-2 Immunoglobulins Flier
Bio-Plex Pro Human IgG SARS-CoV-2 Quantitative Assay Protocol
Bio-Plex Pro Human IgA and IgM SARS-CoV-2 Serology Assays Protocol