Ion-Exchange HPLC System: VARIANT II TURBO

The Gold Standard in
HPLC Technology

For Diabetes Testing, Hemoglobinopathy Testing,
and Quality Control

  • For Demanding
    HbA1c Workloads

    The VARIANT II TURBO System is a fully automated, robust HPLC system for medium to high volume laboratories that identifies HbA1c without common hemoglobin variant interferences.*

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  • lab techs holding blood sample
  • Release your HbA1c Results Faster

    Watch how the VARIANT II TURBO System simplifies A1c operations and eliminates redundant, low value tasks to release 2,500 HbA1c results faster than other non-Bio-Rad HPLC systems.

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  • Every Patient Deserves
    Quality Results

    Confidently report HbA1c results with
    the VARIANT II TURBO System

    • Aids in the diagnosis of patients with diabetes
    • Identifies those at risk of developing diabetes
    • Monitors the progress of those living with diabetes
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  • patient care

Not all HbA1c Assays are Equal

Effects of Different Rare Hb Variants on HbA1c Measurement in Eight Methods

Randie R. Little et al. (2015) Journal of Diabetes and Science and Technology1


The study examined analytical interference from 49 different less common variants comparing seven different HbA1c methods. HbA1c accuracy was assessed as well as the likelihood for the systems to report inaccurate results. The authors noted that previous studies with some assay methods have shown interference with HbA1c measurement from the four most common heterozygous Hb variants (HbAS, HbAE, HbAC, and HbAD).

Study Results

Bio-Rad HPLC systems outperformed other HbA1c testing systems. The VARIANT II TURBO System reported 97.7% accurate results in the presence of hemoglobin variants. The table below illustrates the clinical benefit of Bio-Rad ion-exchange HPLC for patient diagnosis and treatment.

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The authors concluded that in order to ensure accurate HbA1c results, it’s important to know if patients have a hemoglobin variant and if so, how that variant affects their HbA1c results. Laboratories should take care when reporting results if a variant is suspected.

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  • hbf case study infographic
  • Bio-Rad HPLC Reveals HbF for a Diagnosis You Can Trust

    Are You Reporting Valid HbA1c Results?

    HbA1c testing methods that don't see common hemoglobin variants or elevated levels of hemoglobin F might lead to misdiagnosis and unnecessary or delayed patient treatment.

    Case Study Results:**

    • Bio-Rad VARIANT II TURBO System reveals the presence of HbF so you can confidently report HbA1c results to your clinicians.
    • Immunoassays do not reveal the presence of HbF. So you might not know the result was invalid and unknowingly report incorrect results.
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For Quality Patient Care

The VARIANT II TURBO System brings speed, efficiency and accuracy to laboratories demanding a robust system for processing thousands of tests a month.

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    Save Time and Labor

    The fully-automated VARIANT II TURBO System requires minimal maintenance and no sample preparation.

  • rapid throughput icon

    Rapid Throughput

    For Demanding HbA1c Workloads

    Report HbA1c results every 97 seconds with the Clinical Data Management (CDM) software.

  • accuracy icon


    For Better Patient Care

    Ion-exchange HPLC technology is the method of choice for clinicians seeking accurate results without common hemoglobin variant interference.*

  • Watch the video to learn more about the Easy Release Cartridge Holder.

  • Simplify Workflow

    The VARIANT II TURBO Easy Release Cartridge Holder simplifies changing cartridges and prefilters.

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For Use in Diagnosing Diabetes

Be confident in reporting high quality, clinically-relevant HbA1c results to aid physicians in diagnosing those who have diabetes, identifying people at risk for developing the disease, or monitoring the progress of those living with diabetes.

variant II turbo kit

VARIANT II TURBO HbA1c Kit - 2.0***

Superior Performance

HbA1c results reportable with no interference in the presence of:

  • The most common heterozygous hemoglobin variants: HbAS, HbAC, HbAD, and HbAE
  • HbF ≤ 25%
  • Carbamylated hemoglobin (CHb)
  • Labile A1c (LA1c)
  • Acetylated hemoglobins
  • Lipemia ≤ 6,000mg/dL (60g/L)

Confidence in Your Results

NGSP certified, IFCC anchored and CE-marked

Flexible and Efficient

  • Streamline inventory management: Interchangeable kit components with long shelf lives
  • Reduce hands-on time: One calibration per cartridge (2,500 tests) and on-board QC management
  • Maximize workflow: Fully automated walk-away operation with minimal maintenance
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Automate with VARIANT II TURBO Link

Improve your laboratory's workflow with the VARIANT II TURBO Link Hemoglobin Testing System, designed to integrate the VARIANT II TURBO System with the SysmexTM XN-9000 Automated Hematology System.

The fully-automated system combines Bio-Rad's leadership in HbA1c testing with Sysmex's expertise in automation to help you be the difference for your clinicians with timely, accurate results.

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  • intelligent automation icon

    Intelligent Automation

    Integration with the SysmexTM XN-9000 Automated Hematology System provides on-demand HbA1c testing results 24/7.

  • streamlined workflow icon

    Streamlined Workflow

    Sysmex Lavender Top ManagementTM solution and SysmexTM WAM logic rule database provide an efficient and LEAN workflow.

  • unparalleled support icon

    Unparalleled Support

    Backed by Bio-Rad's world-class service and customer support.



1.Little RR et al. (2015). Effects of 49 Different Rare Hb Variants on HbA1c Measurement in Eight Methods. Journal of Diabetes Science and Technology I-8.


*Interferences from common hemoglobin variants: HbAS, HbAC, HbAD, and HbAE were tested. Based on net performance criteria the results were acceptable.

**Data on file at investigating laboratory.

***See VARIANT II TURBO HbA1c Kit - 2.0 Instructions for Use (Catalog # 12000447)