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Advantages of ddPCR™ Technology for Precise CNV Measurements in Cell Lines
Determining copy number variation (CNV) in cell lines used for therapeutic antibody production is essential for ensuring your cell lines produce consistent levels of quality antibody. But traditional techniques are limited in their ability to provide precise, absolute measurements. This is especially true with copy number differences greater than five, which are common when copy numbers have been increased to scale antibody production and meet clinical demands. Many researchers are turning to ddPCR™ technology as an alternative method for rapidly and accurately measuring CNV.
Read this article to learn:
- Why measuring CNV is required for all cell lines producing therapeutic antibodies
- Why traditional approaches, such as qPCR, fall short
- How ddPCR technology can accurately and absolutely identify copy number differences to as few as one copy up to a copy number of 11
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