ANCA Complete Kit

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Overview

Include all slides, reagents, and other components needed for IFA-based detection of ANCA, serological markers of primary necrotizing systemic vasculitis
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Description

Description

The KallestadAutoimmune ANCA IFA Complete Kits contain all necessary reagents for performing tests: human neutrophil substrate slides, FITC conjugate, PBS, mounting medium, negative and positive controls, Evans blue counterstain, cover slips and blotters. Kallestadis the most trusted name in autoimmune testing for more than 25 years. Customers can test for p-ANCA and c-ANCA on a single slide with large cells for clear reactivity. All controls are pre-diluted and ready to use. Wells are spaced for use with a multichannel pipette. Kits are packaged for flexible volume ordering and automation options are available.

Human anti-neutrophil cytoplasmic antibodies (ANCA) are directed against antigenic components mainly present in primary granules of neutrophils. They are serological markers of primary necrotizing systemic vasculitis, particularly in granulomatosis with polyangiitis (GPA) formerly known as Wegener’s granulomatosis. In addition, they have a prognostic interest because, in most cases, their titer is usually correlated to clinical activity during the disease. The IFA method is considered the gold standard for detecting ANCA. When fixed in ethanol, two types of ANCA staining reaction patterns occur: cytoplasmic (c-ANCA) and perinuclear (p-ANCA). The p-ANCA reactions can be confirmed by repeat testing on formalin-fixed slides where p-ANCA reactions convert to c-ANCA.

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29403
Ethanol fixed slides, reagents and controls for immunofluorescent anti-neutrophil cytoplasmic antibody assays (10 x 6 wells)
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29419
Combination of ethanol and formalin fixed slides for anti-neutrophil cytoplasmic antibody immunofluorescence assays (5 x 6+6 wells)
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29418
Formalin fixed slides for anti-neutrophil cytoplasmic antibody immunofluorescence assays (5 x 6 wells)
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29417
Ethanol fixed slides for anti-neutrophil cytoplasmic antibody immunofluorescence assays (5 x 12 wells)
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29416
Ethanol fixed slides for use in anti-neutrophil cytoplasmic antibody immunofluorescence assays (5 x 6 wells)
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29411
Fluorescein conjugated to IgG for anti-neutrophil cytoplasmic antibody immunofluorescence assays (5 mL)
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(Discontinued) Sample Diluent
29407
Solution to dilute samples for immunofluorescent anti-neutrophil cytoplasmic antibody assays (60 mL)
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(Discontinued) Mounting Medium
29410
Solution to adhere cover slips to slides for anti-neutrophil cytoplasmic antibody immunofluorescence assays (5 mL)
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29414
6-well blotters for anti-neutrophil cytoplasmic antibody immunofluorescence assays (box of 12)
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29415
12-well blotters for anti-neutrophil cytoplasmic antibody immunofluorescence assays (box of 12)
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29400
Positive control for cytoplasmic staining pattern in immunofluorescent anti-neutrophil cytoplasmic antibody assays (0.5 mL)
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29408
Negative control for anti-neutrophil cytoplasmic antibody immunofluorescence assays (0.5 mL)
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29401
Positive control for nuclear and perinuclear staining pattern in immunofluorescent anti-neutrophil cytoplasmic antibody assays (0.5 mL)