Overcoming Purification Hurdles with Mixed-Mode Chromatography

Overcoming Purification Hurdles with Mixed-Mode Chromatography

May 4, 2016
Dr. Mark Snyder
Bio-Rad Laboratories


Dr. Mark Snyder, a leading expert in the field of protein purification, presents the purification process development for two very different targets, adenovirus and bacterial surface proteins. In both cases a two-step column process results in a preparation with high yield and activity and very low host cell protein and DNA contamination. Conditions used make the methods suitable for large-scale production.

In this webinar you will learn about:

  • Advantages of mixed-mode resins
  • Optimizing purification process development
  • Procedures for purifying adenovirus and bacterial surface proteins

About the Speaker
Dr. Mark Snyder is the Manager of the Applications Group in the Process Chromatography Division of Bio-Rad Laboratories. Mark holds an undergraduate degree from MIT and a PhD in biochemistry from the University of California–Berkeley. He has more than 20 years of experience in protein purification and process development at Scios, XOMA, Bayer, and Bio-Rad. Mark has participated in numerous process licenses and has published many articles in peer reviewed journals.