QX600 Droplet Digital PCR System

QX600 Droplet Digital PCR System

The QX600™ Droplet Digital™ PCR System enables advanced six-color multiplexing, allowing clear discrimination of multiple targets with assays that are cross-compatible with the QX200™ Droplet Digital PCR System. The QX600 System is designed for researchers who need to quantify multiple targets with high accuracy, reproducibility, and sensitivity.

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Overview

The QX600 Droplet Digital PCR System (ddPCR™) offers advanced six-color multiplexing and absolute quantification of nucleic acid, while delivering the best-in-class performance you have come to expect from Bio-Rad’s ddPCR systems.

Benefits of the QX600 Droplet Digital PCR System

The QX600 Droplet Reader offers users:

  • Sensitive multiplexing
    • Six-color detection capability (FAM, HEX, Cy5, Cy5.5, ROX, and ATTO 590)
    • Quantification of up to 12 targets in a single well
    • Absolute quantification with 0.1% or better sensitivity
    • Sensitive and precise gene expression multiplexing
  • Accurate and reproducible results
    • Confidence in your results bolstered by a system qualified by standards from National Measurement Institute (NMI), Australia
    • Sets the standard for reproducibility as demonstrated in numerous studies
  • Powerful software
    • User-friendly analysis
    • Audit trails and tools for U.S. FDA 21 CFR Part 11 compliance with premium edition
    • Assay protocol files for automated data analysis and reporting with premium edition
  • Portfolio compatibility
    • Cross-compatibility with QX200 reagents, assays, and consumables
    • Extensive menu of pre-existing ddPCR assays
    • System capable of running both TaqMan® and EvaGreen chemistries

Applications of the QX600 Droplet Digital PCR System

The QX600 System enhances a wide variety of applications, including: oncology research, gene expression, next generation sequencing (NGS) orthogonal testing, cell and gene therapy, food and wastewater testing.

  • Oncology research — The QX600 System collects more information per well, preserving precious circulating tumor DNA (ctDNA) and tumor samples.
    • Structural variant analysis
    • Rare variant detection
    • Copy number variation
    • Methylation detection
    • Loss of heterozygosity
  • Gene Expression — Employ the extreme precision of the QX600 System to quantify small-fold changes in low abundance RNA molecules.
  • Next generation sequencing (NGS) orthogonal testing — With the QX600 System perform accurate quantification and qualification of NGS libraries without the use of a standard curves.
  • Cell and gene therapy — Accelerate therapeutics discovery with highly-advanced multiplexing afforded by the QX600 System.
    • Residual DNA detection in biologics
    • Genome edit confirmation
  • Food testing — Use the QX600 System to perform routine evaluation of genetically modified organisms (GMO) and pathogen contamination detection.
  • Wastewater testing — Leverage the QX600 System to perform population-wide monitoring of established and emerging pathogens.

Additional Instruments

The QX600 Droplet Digital PCR System requires the use of the PTC Tempo Deepwell Thermal Cycler or C1000 Touch Thermal Cycler with 96–Deep Well Reaction Module and the PX1 PCR Plate Sealer.

Required Accessories

ddPCR Reagents for Hydrolysis Probe-Based Applications

ddPCR Reagents for EvaGreen Applications

Specifications

Starting sample size, µl
20
QX200 Droplet Generator capacity
1–8 samples/cartridge
Droplets per 20 µl sample
20,000
QX600 Droplet Reader capacity
1–96 samples
Sample illumination
Light-emitting diodes
Sample detection
Avalanche photodiodes
Detection channels
FAM (EvaGreen), HEX (VIC), Cy5, Cy5.5, ROX, and ATTO 590
QX200 Droplet Generator dimensions (W x D x H)
28 x 36 x 13 cm (11 x 14 x 5")
QX600 Droplet Reader dimensions (W x D x H)
66 x 52 x 29 cm (26 x 20 x 11")

Ordering

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17007769

Discover how the QX600 Droplet Digital PCR System enables 6-color multiplexing, allowing clear discrimination of multiple targets within samples. 

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12013328
(Discontinued) QX600 Droplet Reader
12013328

The QX600™ Droplet Reader enables advanced six-color multiplexing, allowing clear discrimination of multiple targets with assays that are cross-compatible with the QX200™ Droplet Digital™ PCR (ddPCR™) System. The QX600 Droplet Reader is designed for investigators who need to quantify multiple targets with high accuracy, reproducibility, and sensitivity. 

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1864002

Droplet generator for EvaGreen or probe-based digital PCR applications, for use with QX200™ Droplet Digital™ PCR System

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QX manager Edition
12018108

QX600 and QX200 System control and analysis software, with traceability for secure environments

Accessories

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(Discontinued) PX1 PCR Plate Sealer
1814000
PCR plate sealer, includes heat sealing instrument, plate support block that holds 96-well and 384-well plates, sealing frame, power cord
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1851197

Modular thermal cycler platform, includes C1000 Touch Thermal Cycler chassis, 96–deep well reaction module, USB flash drive

Kits & Reagents

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12005909

1.2 ml (2 x 0.6 ml), 4x supermix, for use in sample preparation for droplet generation in the QX600/QX200 Droplet Digital PCR Systems

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12005910

3 ml (5 x 0.6 ml), 4x supermix, for use in sample preparation for droplet generation in the QX600/QX200 Droplet Digital PCR Systems

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12005911

12.5 ml (5 x 2.5 ml), 4x supermix, for use in sample preparation for droplet generation in the QX600/QX200 Droplet Digital PCR Systems

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1863023

2 ml (2 x 1 ml), 2x supermix, for use in sample preparation for droplet generation in the QX600/QX200 Droplet Digital PCR Systems

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1863024

5 ml (5 x 1 ml), 2x supermix, for use in sample preparation for droplet generation in the QX600/QX200 Droplet Digital PCR Systems

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1863025

25 ml (5 x 5 ml), 2x supermix, for use in sample preparation for droplet generation in the QX600/QX200 Droplet Digital PCR Systems

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1863026

2 ml (2 x 1 ml), 2x supermix, for use in sample preparation for droplet generation in the QX600/QX200 Droplet Digital™ PCR Systems

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1863010

5 ml (5 x 1 ml), 2x supermix, for use in sample preparation for droplet generation in the QX600/QX200 Droplet Digital™ PCR Systems

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1863027

25 ml (5 x 5 ml), 2x supermix, for use in sample preparation for droplet generation in the QX600/QX200 Droplet Digital™ PCR Systems

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1863028

50 ml (10 x 5 ml), 2x supermix, for use in sample preparation for droplet generation in the QX600/QX200 Droplet Digital™ PCR Systems

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1864021

200 x 20 µl reaction kit, for absolute quantification of target RNA in the QX600/QX200 Droplet Digital™ PCR Systems

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1864022

500 x 20 µl reaction kit, for absolute quantification of target RNA in the QX600/QX200 Droplet Digital™ PCR Systems

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1864033

200 x 20 µl reactions, 2 ml (2 x 1 ml), 2x supermix, for use in sample preparation with the droplet generator in the QX600/QX200 Droplet Digital™ PCR System

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1864034

500 x 20 µl reactions, 5 ml (5 x 1 ml), 2x supermix, for use in sample preparation with the droplet generator in the QX600/QX200 Droplet Digital™ PCR System

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1864035

2,500 x 20 µl reactions, 25 ml (5 x 5 ml), 2x supermix, for use in sample preparation with the droplet generator in the QX600/QX200 Droplet Digital™ PCR System

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1864036

5,000 x 20 µl reactions, 50 ml (10 x 5 ml), 2x supermix, for use in sample preparation with the droplet generator in the QX600/QX200 Droplet Digital™ PCR System

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1863040

200 x 20 µl reactions, includes ddPCR Library Quantification Assay and ddPCR Supermix for Probes (No dUTP), for quantification of Illumina TruSeq libraries using the QX200™/QX100™ ddPCR™ Systems

Consumables

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1864005
14 ml (2 x 7 ml), oil for use with the droplet generator in the QX200™ Droplet Digital™ PCR System
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1864006
70 ml (10 x 7 ml), oil for use with the droplet generator in the QX200™ Droplet Digital™ PCR System
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1814040
Pkg of 100, foil seals for PCR and QX200/QX100 Droplet Digital PCR System applications, for use with PX1 PCR Plate Sealer

Documents

Number Description Options
3600
ddPCR Family Brochure
10000153877
QX600 Droplet Reader and QX Manager Software Standard Edition User Guide
3266
QX600 Droplet Reader
3557
QX600™ Droplet Digital™ PCR System Brochure
3560
Mutation Detection Multiplexing Using the QX600 Droplet Digital PCR System
3577
Multiplex Assay Design for Epidemiological Wastewater Monitoring with Droplet Digital™ PCR (ddPCR™) Technology
3578
Reproducible High-Resolution Characterization of AAV Vector Genome Identity Using the QX600 Droplet Digital PCR Platform