Unlock the Full Potential of CTCs

CTCs offer a non-invasive window into cancer biology. Isolated from blood samples and other biofluids, these rare cells provide critical insights into metastasis, therapeutic resistance, and tumor evolution. 

However, their rarity—often as few as one in a billion blood cells—makes CTC isolation and analysis a technical challenge. This is where Bio-Rad’s innovative tools assist scientists the most.

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  Inefficient CTC Isolation

  Extracting CTCs from billions of blood cells while maintaining their viability and integrity is a critical bottleneck. Conventional methods like density gradient centrifugation and negative selection are time-consuming and often fall short, leading to sample loss or contamination.

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  Low-Resolution CTC Analysis

  CTC analysis at the molecular level uncovers critical insights into cancer progression, metastasis, and resistance, but their rarity demands advanced tools to generate reliable, high-resolution data.

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  Consistency and Reproducibility

  CTC workflows must produce consistent results to support translational research for clinical applications. Variability and workflow inefficiencies can hinder progress toward meaningful discoveries.

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Leveraging Microfluidics for CTC and CTC Cluster Capture, Enrichment, and Enumeration

Discover an efficient sized-based isolation solution with the Genesis Platform. Celselect Slides™ capture single and clustered CTCs, filtering out smaller blood components like WBCs, RBCs, and platelets while being gentle enough to recover viable, living cells for proliferation and culturing workflows. 

Explore the Genesis Platform

Unlock the full potential of your CTC isolation and analysis workflows by incorporating the ddSEQ Single Cell Isolator and ddSEQ library prep kits. These tools empower you with high-resolution data to uncover the critical insights hidden within the transcriptome and epigenome of these rare cells.

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ddSEQ Single Cell Isolator

Study the transcriptome and epigenome of CTCs isolated with Genesis. This space-efficient instrument partitions individual CTCs captured with the Genesis System for downstream single-cell workflows, including 3’ scRNA-seq or scATAC-seq.

Enhance your analysis of CTCs recovered with the Genesis System using ddPCR and PrimePCR™ Assays, enabling absolute quantification of biomarkers, rare mutations, and gene expression changes. This high-sensitivity approach ensures reproducible and high-resolution data for cancer research and translational applications.

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QX600™ ddPCR System

Analyze and quantify rare nucleic acid events, transcript levels, and biomarkers  from CTCs with ultra-high sensitivity, precision, and advanced multiplexing capabilities. This innovative technology delivers reproducible results, even from minimal sample input.

Shaping the Future of Liquid Biopsy Research

Transform your translational research with advanced liquid biopsy workflows. Bio-Rad’s ddPCR technology provides sensitivity for ctDNA and CTC analysis, uncovering actionable insights into disease states and therapy efficacy.

Hear What Expert ddPCR Users are Saying

Drive your research forward by coupling the Genesis platform, ZE5 Cell Analyzer, validated antibodies, and StarBright™ Dyes for high-throughput, multiparametric flow cytometry for CTC characterization, immune profiling, and biomarker detection.

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ZE5™ Cell Analyzer

Simplify your workflows with an automated flow cytometer featuring five lasers, 30 parameters, and a flexible sample loader. This device enables ultra-sensitive, multiparametric immune profiling of CTCs with unparalleled speed and accuracy.

The Genesis Platform enables the isolation of rare CTCs with unmatched sensitivity, yielding consistent, high-quality results. When paired with our ddSEQ, ddPCR, and flow cytometry solutions, it minimizes variability, ensures reproducible performance across projects, and is flexible for sample input. These tools empower you to adapt effortlessly, meeting the evolving demands of your downstream workflows.

Explore the Genesis Platform

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  Dual Isolation and Profiling of CTCs and ctDNA from a Single Liquid Biopsy Sample

  See how the Genesis System and ddPCR technology enable simultaneous isolation of CTCs and ctDNA from liquid biopsy samples, delivering noninvasive, high-resolution molecular insights for cancer monitoring and therapeutic decision-making.

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  Profiling EGFR DNA Mutation Analysis in Circulating Rare Cells Using the Genesis Cell Isolation System with Celselect Slides and ddPCR

  Learn how the Genesis Cell Isolation System and ddPCR efficiently detect EGFR mutations in rare CTCs, providing absolute quantification for cancer biomarker discovery and treatment monitoring.

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  ddSEQ™ Single-Cell 3' RNA-Seq Kit User Guide

  Explore workflows, best practices, and protocols for the Bio-Rad ddSEQ Single-Cell 3' RNA-Seq Kit, covering single-cell encapsulation, cDNA library preparation, and sequencing.

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  Enrichment and Molecular Profiling of Tumor Cells for Lung Cancer Biomarker Discovery

  Discover how the Genesis Cell Isolation System, Celselect Slides, RNA-Seq, and RT-qPCR enable tumor cell enrichment and biomarker discovery for lung cancer using liquid biopsies.

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  Antibody Selection and Preparation for Circulating Tumor Cell (CTC) and Rare Cell Isolation

  Optimize antibody selection and staining for rare cell analysis with the Bio-Rad Celselect Slides Enumeration Assay. This guide provides workflows and tips for accurate cell identification.

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  ddSEQ™ Single-Cell Applications Sample Preparation Guide

  Understand best practices for single-cell preparation with Bio-Rad’s ddSEQ Sample Preparation Guide. This resource provides protocols, best practices, and workflows for RNA-Seq and ATAC-Seq assays.