ddSEQ Isolator for Single-Cell Sequencing

Overview

ddSEQ Single-Cell Isolator is a droplet-based single cell isolation system for single-cell gene expression and gene regulation studies. The system includes the isolator, test cartridges and the cartridge holder

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Description

The ddSEQ Single-Cell Isolator is part of the Bio-Rad Single-Cell Next-Generation Sequencing (NGS) Solution, which works with the Bio-Rad Library Preparation Kits for single-cell 3’ RNA-Seq and ATAC-Seq. The technology utilizes disposable microfluidic cartridges to coencapsulate single cells or single nuclei and barcoded beads into subnanoliter droplets, where cell-bead pairing and barcoding occur. 3’ RNA-Seq and ATAC-Seq libraries are subsequently prepared and sequenced, and analysis is conducted with the Bio-Rad Omnition Analysis Software.

Features and Benefits

Process hundreds to tens of thousands of cells per experiment
Sensitive and unbiased characterization of gene expression and gene regulation
Scalable solution to accommodate a wide range of experimental designs
Agnostic to mammalian cell size, enabling unbiased profiling of diverse cell populations
End-to-end single-cell sequencing solution with simple, powerful data analysis

Applications and Uses

Gain insights into cellular heterogeneity, empowering a wide range of fields including, but not limited to:

Cancer research — cellular expansion of clonal cells in tumors and mutations that lead to differences in gene expression and drug response
Immunology research — B Cell and T Cell characteristic and functional analyses
Neurology research — normal brain function, neurological disease and psychological disorders
Stem cell research — cell fate, cell development and differentiation, including reverse engineering tissues