Genesis System

Genesis System

Overview

The Genesis System with Celselect Slide Technology, automates the capture of cells for recovery or on-slide immunolabeling.

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Description

Description

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The Genesis System with Celselect Slides™ enable the capture of cells from liquid biopsies and other sample types.

The Celselect Slide utilizes 56,400 individual microchambers with a pore size that captures cells in the range of 8-30 µm (figure 1):

Illustration of the microfluidic chambers on the Celselect Slide
llustration of the microfluidic chambers on the Celselect Slide with a blood sample example showing capture of CTCs while smaller blood components (<8 µm) flow through.

In Figure 2, red blood cells and smaller white blood cells flow through the pores while cells larger than 8 µm are captured. Circulating tumor cells (CTCs) and CTC clusters for the majority of cancers types are captured by the Celselect Slide.

Genesis System Figure 2
Figure 2
Blood cell and CTC sizes relative to the Celselect Slide pore size.

After capture, the enriched cells can be recovered for downstream analysis such as single-cell genomics, digital PCR, or culture. Alternatively, cells can be immunolabeled on-slide for immunofluorescent applications such as enumeration.

For applications which require protocol optimization or creation of new protocols for custom reagents or antibody labeling, the Genesis Protocol Builder Software Tool enables adjustment of parameters such as reagent dispensing, pump pressures, and incubation settings. Building custom protocols is performed on your local computer.

Features and Benefits

  • Size-based cell capture from liquid biopsies and other sample types
  • Recover viable cells for downstream analysis or on-slide immunolabeling for enumeration
  • Genesis Protocol Builder Software Tool enables optimization for different samples types or antibody stains

Celselect Slide Enumeration/Immunolabeling Workflow

Sample is prepared with fixing reagent and loaded on to the instrument. 8-30 µm sized cells are captured and immunolabeled automatically in the Celselect Slide microchambers while smaller components flow through the slide to waste. The Celselect Slide is imaged on an automated microscope and files can be imported for reporting.

Celselect Enumeration Workflow
Add fixing reagent to sample and load sample on to the instrument. Sample and staining reagents are prepped according to predefined protocols
Genesis System automates capture and immunolabeling on Celselect Slides™
Image Celselect slide on an automated microscope
Import files from microscope to Rare Cell Analysis Software, confirm cells of interest, and generate report

 

Celselect Slide Enrichment Workflow

Sample is prepared with the dilution buffer and loaded on to the instrument. 8-30 µm sized cells are captured automatically in the Celselect Slide while smaller components (<8 µm) flow through the slide to waste.

Celselect Enrichment Workflow
Add dilution buffer to sample and load sample on to the instrument
Genesis System automates capture and recovery of cells
Cells can be characterized with methods such as sequencing (bulk or single-cell), digital PCR, FISH, flow cytometry, or cells cultured for further in vitro and in vivo analysis

 

Enriched cells are recovered in a single tube for downstream analysis, such as:

Related Products

Related Categories

  • Cell Capture and Recovery

Specifications

Specifications

Sample input
4 ml
Parallel Sample Processing
2 samples
Cell Capture Technology
Microfluidics
Dimensions
Instrument open: 17.2” W x 23.0” D x 24” H
Instrument closed: 17.2” W x 23.0” D x 15.9” H
Open System
Flexibility to use alternative reagents, antibodies. Adjustable protocols parameters.

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CEL20101 Genesis System
CEL20101

The Genesis Cell Isolation System is designed for automated selection and capture of 8µm-30µm cells by size. It includes an intuitive touch-screen interface, integrated reagent dispensing and slide temperature control.

Download

Download

Windows Rare Cell Analysis Software
Window-Rare-Cell-V1.0

Analysis Software enables users to create custom algorithms to identify and analyze images of cells isolated and labeled on Celselect Slides 

Mac Rare Cell Analysis Software
Mac-Rare-Cell-V1.0

Analysis Software enables users to create custom algorithms to identify and analyze images of cells isolated and labeled on Celselect Slides

Documents

Documents

Number Description Options
3267
Celselect Slide Technology Application Note
3439
Celselect Publication List
10000160281
Rare Cell Analysis Software Release Notes
3463
Rare Cell Analysis Software User Manual