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      ProteOn™ XPR36 Protein Interaction Array System

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      Overview

      The ProteOn™ XPR36 Protein Interaction Array System is an SPR optical biosensor that provides real-time data on the affinity, specificity, and interaction kinetics of protein interactions.
      Read full description Ordering Information

      Description

      Description

      Discontinued Product

      The ProteOn XPR36 Instrument has been discontinued. All other ProteOn System products are still available for purchase. We will continue to provide support for ProteOn Systems until July, 2020.
      Please contact Bio-Rad Technical Support for additional information.

      The ProteOn™ XPR36 Protein Interaction Array System is an SPR optical biosensor that provides real-time data on the affinity, specificity, and interaction kinetics of protein interactions. Using XPR technology*, a unique approach to multiplexing, this system generates a 6 x 6 interaction array for the simultaneous analysis of up to six ligands with up to six analytes. The ProteOn XPR36 System increases the throughput, flexibility, and versatility of experiment design, enabling the completion of more experiments in less time:

      • Analyze up to 36 different protein interactions in a single run, on a single chip
      • Perform a complete kinetic analysis in a single run
      • Measure a variety of experimental conditions simultaneously in parallel
      • Screen multiple panels of analytes

      See the ProteOn Technology and Applications videos for more information about how the ProteOn system works and how it can be applied to drug discovery and to address important experimental questions.

      The ProteOn XPR36 protein interaction analysis system includes all of the components required for interaction analysis: instrumentation, ProteOn Manager™ Software, ProteOn Sensor Chips, buffer and reagent kits, and protocol development kits.

      User-friendly ProteOn Manager Software uses a flexible, guided approach to coordinate instrument control, experiment setup, and data analysis.

      Key Features and Benefits

      • Novel 6 x 6 array design
      • Real-time data acquisition
      • Analysis of interaction kinetics, binding affinity, and analyte concentration
      • No radiochemical or fluorescent labels needed
      • Integrated system

      Applications and Uses

      • Antibody characterization and development
      • Large and small molecule drug development
      • Protein interface analysis
      • Protein complex and cascade analysis

      *The ProteOn XPR36 System is covered by Bio-Rad patents, including United States patent numbers 8,111,400, 8,105,845, 7,999,942, and 7,443,507.

      This product or portions thereof is manufactured and sold under license from GE Healthcare under United States patent numbers 5,554,541, 7,736,587, and 8,021,626, and any international patents and patent applications claiming priority.

      Related Technologies

      Related Products

      Specifications

      Specifications

      Number of interaction spots
      36
      Number of interspot references
      42
      Response uniformity
      <2% CV
      Refractive index range
      1.33–1.37 refractive index units
      Dynamic range, RU
      1–40,000
      Baseline noise
      <1 RU, 1–20,000 RU
      <1.5 RU, 20,000–40,000 RU
      Baseline drift
      <1 RU/min (15–40°C)*
      Operating temperature range
      15–40°C*
      Autosampler temperature range
      2–35°C
      Sample configuration
      72 x 1.5 ml vials or 2 x 96-well microplates
      CCD
      12-bit digital camera
      Acquisition rate
      3 Hz (3 images/sec), average 3 images/data point
      Weight, kg
      85
      Dimensions (W x H x D), cm
      95 x 58 x 50
      Controller with 19" flat panel monitor (1,280 x 1,024 pixels) supplied with instrument
       
      * Not lower than 15°C below room temperature.
       

      Ordering

      Ordering

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      (Discontinued) ProteOn XPR36 Protein Interaction Array System
      1760100
      100–240 V, includes ProteOn XPR36 instrument, ProteOn Manager™ software, controller/display, maintenance kit (#176-4100), One-shot Kinetics™ kit (#176-1010), buffers, and accessories
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      (Discontinued) ProteOn Controller and Display
      1760300
      PC and 19 in. flat-panel monitor (1,280 x 1,024 pixels), for use with the ProteOn XPR36 protein interaction array system
      176-0200_tn.jpg
      (Discontinued) ProteOn Manager™ Software
      1760200
      Software for ProteOn XPR36 instrument control, experiment design, data collection, and analysis, CD-ROM, includes HASP key

      Accessories

      Accessories

      176-6000_tn.jpg
      (Discontinued) ProteOn Sample Rack
      1766000
      Pkg of 1, rack for 72 ProteOn sample vials (1.5 ml); for use with the ProteOn XPR36 protein interaction array system
      176-6001_tn.jpg
      (Discontinued) ProteOn Sample Rack Needle Arm
      1766001
      Pkg of 1, needle holder for rack autosampler layout and needle configuration in the ProteOn XPR36 system; accommodates ProteOn sample rack
      176-6002_tn.jpg
      (Discontinued) ProteOn Microplate Needle Arm
      1766002
      Pkg of 1, needle holder for microplate autosampler layout and needle configuration in the ProteOn system; accommodates standard and deep well microplates
      176-6003_tn.jpg
      (Discontinued) ProteOn Needles
      1766003
      Pkg of 6, needle, accommodates the ProteOn sample rack and ProteOn microplate needle holders
      176-6004_tn.jpg
      (Discontinued) ProteOn Wash Station
      1766004
      Pkg of 1, needle wash station, for use with ProteOn XPR36 protein interaction array system
      176-2700_tn.jpg
      (Discontinued) ProteOn Running Buffer Bottle
      1762700
      Pkg of 1 bottle, holds 2 L running buffer
      176-0315_tn.jpg
      (Discontinued) ProteOn Communication Cable
      1760315
      Pkg of 1, cable used to connect the controller to the ProteOn XPR36 protein interaction array instrument
      176-4114_tn.jpg
      (Discontinued) ProteOn XPR36 Buffer Inlet Filters
      1764114
      Pkg of 2, buffer inlet filters for use with the ProteOn XPR36 protein interaction array system

      Documents

      Documents

      Number Description Options
      6550
      Building New Anti-HIV Molecules with Bio-Rad’s ProteOn XPR36 System, Rev A
      6132
      The ProteOn HTG Sensor Chip: Novel Surface for Stable Capture of Histidine-Tagged Proteins for Protein-Protein Interaction Analysis, Rev A
      6299
      Guide to SPR Data Processing on the ProteOn XPR36 Protein Interaction Assay System, Rev A
      6300
      Guide to SPR Data Analysis on the ProteOn XPR36 System, Rev A
      6295
      ProteOn™ Sensor Chips, Tips and Techniques, Rev A
      5948
      Attachment of Membrane Protein Interactions Using Lipoparticles Bound to the Surface of the ProteOn XPR36 Sensor Chips, Rev A
      5968
      Screening and Characterization of Human Immunoglobulin G Binding Peptides Using the ProteOn XPR36 Protein Interaction Array System, Rev A
      5960
      High-Throughput Profiling of Kinase Inhibitors Selectivity Using the ProteOn™ XPR36 Protein Interaction Array System, Rev A
      5390
      ProteOn XPR36 Protein Interaction Array System Brochure, Rev D
      5413
      ProteOn XPR36 Hardware Product Information Sheet, Rev B
      5627
      ProteOn Manager Software Product Information Sheet, Rev C
      5404
      ProteOn™ Sensor Chips Product Information Sheet, Rev F
      5410
      ProteOn Protocol Development Kits Product Information Sheet, Rev B
      5409
      Protein Interaction Analysis Ordering Information Sheet, Rev E
      5819
      ProteOn XPR36 Protein Interaction Array System: Regulatory Tools for Drug Development Product Focus, Rev A
      5965
      Rapid, High-Throughput Screening of Protein Kinase Inhibitors Using the ProteOn XPR36 Protein Interaction Array System, Rev B
      5846
      Determining the Binding Kinetics of HIV-1 Nucleocapsid Protein to Six Densities of Oligonucleotide Using the ProteOn XPR36 Protein Interaction Array System, Rev A
      5412
      Antibody Characterization and Development: ProteOn XPR36 Protein Interaction Array System Application Guide, Rev C
      5540
      Screening, Ranking, and Epitope Mapping of Anti-Human IL-9 Supernatants, Rev A
      5820
      Rapid Screening and Selection of Optimal Antibody Capturing Agents Using the ProteOn XPR36 Protein Interaction Array System, Rev A
      3172
      Rapid and Efficient Determination of Kinetic Rate Constants Using the ProteOn XPR36 Protein Interaction Array System, Rev B
      5360
      Rapid and Detailed Analysis of Multiple Antigen-Antibody Pairs Using the ProteOn XPR36 Protein Interaction Array System, Rev A
      5367
      Rapid Optimization of Immobilization and Binding Conditions for Kinetic Analysis of Protein-Protein Interactions Using the ProteOn™ XPR36 Protein Interaction Array System, Rev A
      5368
      Anaylsis of Multiple Protein-Protein Interactions Using the ProteOn XPR36 Protein Interaction Array System, Rev B
      5358
      Mechanisms of Protein-Protein Binding: Double-Mutant Cycle Analysis Using the ProteOn XPR36 System, Rev A
      5822
      How to Perform Excluded Volume Correction on the ProteOn XPR36 Protein Interaction System Protocol Guide, Rev C
      5797
      Rapid Assay Development and Optimization for Small Molecule Drug Discovery, Rev B
      5679
      Applications of the ProteOn GLH Sensor Chip: Interactions Between Proteins and Small Molecules, Rev A
      5449
      Applications of the ProteOn NLC Sensor Chip: Antibody-Antigen, DNA-Protein, and Protein-Protein Interactions, Rev B
      5434A
      ProteOn XPR36 Protein Interaction Array System Folder. (Contains bulletins 3172, 5358, 5360, 5367, 5368, 5390, 5404, 5409, 5410, 5413, 5538, and 5465 DVD, depending on availability)
      6161
      Highly Efficient Lipoparticle Capture and SPR Binding Kinetics of a Membrane Protein Using the ProteOn XPR36 Protein Interaction Array System, Rev A
      6254
      The ProteOn™ HTE Sensor Chip: Novel Surface for Stable Capture of Histidine-Tagged Proteins for Protein-Small Molecule Interaction Analysis, Rev A
      6449
      Novel Liposome-Capture Surface Chemistries to Analyze Drug-Lipid Interaction using the ProteOn XPR36 System, Rev A
      6414
      ProteOn™ XPR36 Experimental Design and Application Guide, Rev B