ProteOn™ Manager Software

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Overview

ProteOn Manager software provides a single interface to control instrument setup, experiment design, data collection, and protein interaction analysis.

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Description

Description



ProteOn Manager™ software guides the user through protein interaction studies, allowing sophisticated experiments to be completed with ease. A single software interface controls instrument setup, experiment design, data collection, and analysis.

Instrument Control
The instrument control panel includes maintenance wizards that direct the user to weekly and monthly cleaning protocols to keep the instrument running at optimum performance. Additionally, the instrument control panel logs all instrument functions in a searchable and exportable database.

Protocol Design
The protocol editor offers a variety of formats for creating a protocol easily. Users may design templates, create custom protocols, or use the automatic protocol option depending on their workflow. Samples may be imported or manually entered using copy and paste commands or using group functions for iterative tasks. Pull-down menus help navigate samples into flexible locations. Once samples are entered, data types and concentration can be selected to aid in downstream analysis. Graphics are shown to help visualize orientation of sample injection flow.

Sample Management
Sample layouts are visually displayed in several ways. Position is indicated by color-coordinated graphics that represent the sample position in the protocol. Pull-down menus in the sample panels allow the user to easily switch sample locations while retaining all sample information.

Data Collection
The software interface allows users to visualize real-time interactions on all 36 spots. Raw data collected from the instrument can be processed and analyzed with ProteOn Manager software. Data at any stage — raw, processed, or analyzed — can be exported. Sensorgrams may be exported in either a metafile or data format for use in presentations and publications.

Autoprocessing
Data processing is easy with the click of a single button with undo functions to illustrate the effects of different processing parameters to a data set. Users can instantly adjust the baseline and injection alignment parameters and remove artifacts using the Autoprocess button. Data processing functions can also be performed manually.

The software supports a comprehensive set of referencing options, including interspot or channel referencing, real-time injection reference, double referencing, and excluded volume correction for solvents like DMSO. Referencing is selected and applied with the click of a button.

Data Analysis
Data analysis is made simple through the use of intuitive software wizards. Wizards allow step-by-step data collection for kinetic, equilibrium, and concentration analysis. Association, dissociation, and affinity constants are reported in the data table and can be easily exported. Each analysis mode allows the user to define analysis parameters, perform calculations, and review and print results. Analysis with molecular weight normalization is available. Seven kinetic fit models are supported, including Langmuir 1:1, Langmuir with drift, Langmuir mass transfer, bivalent analyte, heterogeneous analyte, heterogeneous ligand, and conformational change, as well as separate off-rate only analysis.

ProteOn Manager Software, Security Edition
New compliance features enable the user to turn on security features that comply with U.S. FDA 21 CFR Part 11 regulations. Features of the Security Edition software include audit trails, electronic signatures, data validation, user logins and permissions, and closed-system security. Signatures can be verified, ensuring data consistency within the instrument.

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1760200
Software for ProteOn XPR36 instrument control, experiment design, data collection, and analysis, CD-ROM, includes HASP key
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1760210
1-user license, security edition software for ProteOn XPR36 instrument control, allows U.S. FDA 21 CFR Part 11 compliance, CD-ROM, includes HASP key

Documents

Documents

Number Description Options
6550
Building New Anti-HIV Molecules with Bio-Rad’s ProteOn XPR36 System, Rev A
6300
Guide to SPR Data Analysis on the ProteOn XPR36 System, Rev A
6299
Guide to SPR Data Processing on the ProteOn XPR36 Protein Interaction Assay System, Rev A
5390
ProteOn XPR36 Protein Interaction Array System Brochure, Rev D
5968
Screening and Characterization of Human Immunoglobulin G Binding Peptides Using the ProteOn XPR36 Protein Interaction Array System, Rev A
5413
ProteOn XPR36 Hardware Product Information Sheet, Rev B
5627
ProteOn Manager Software Product Information Sheet, Rev C
5404
ProteOn™ Sensor Chips Product Information Sheet, Rev F
5410
ProteOn Protocol Development Kits Product Information Sheet, Rev B
5409
Protein Interaction Analysis Ordering Information Sheet, Rev E
5819
ProteOn XPR36 Protein Interaction Array System: Regulatory Tools for Drug Development Product Focus, Rev A
5965
Rapid, High-Throughput Screening of Protein Kinase Inhibitors Using the ProteOn XPR36 Protein Interaction Array System, Rev B
5846
Determining the Binding Kinetics of HIV-1 Nucleocapsid Protein to Six Densities of Oligonucleotide Using the ProteOn XPR36 Protein Interaction Array System, Rev A
5412
Antibody Characterization and Development: ProteOn XPR36 Protein Interaction Array System Application Guide, Rev C
5540
Screening, Ranking, and Epitope Mapping of Anti-Human IL-9 Supernatants, Rev A
5820
Rapid Screening and Selection of Optimal Antibody Capturing Agents Using the ProteOn XPR36 Protein Interaction Array System, Rev A
3172
Rapid and Efficient Determination of Kinetic Rate Constants Using the ProteOn XPR36 Protein Interaction Array System, Rev B
5360
Rapid and Detailed Analysis of Multiple Antigen-Antibody Pairs Using the ProteOn XPR36 Protein Interaction Array System, Rev A
5367
Rapid Optimization of Immobilization and Binding Conditions for Kinetic Analysis of Protein-Protein Interactions Using the ProteOn™ XPR36 Protein Interaction Array System, Rev A
5368
Anaylsis of Multiple Protein-Protein Interactions Using the ProteOn XPR36 Protein Interaction Array System, Rev B
5358
Mechanisms of Protein-Protein Binding: Double-Mutant Cycle Analysis Using the ProteOn XPR36 System, Rev A
5822
How to Perform Excluded Volume Correction on the ProteOn XPR36 Protein Interaction System Protocol Guide, Rev C
5797
Rapid Assay Development and Optimization for Small Molecule Drug Discovery, Rev B
5679
Applications of the ProteOn GLH Sensor Chip: Interactions Between Proteins and Small Molecules, Rev A
5449
Applications of the ProteOn NLC Sensor Chip: Antibody-Antigen, DNA-Protein, and Protein-Protein Interactions, Rev B
5434A
ProteOn XPR36 Protein Interaction Array System Folder. (Contains bulletins 3172, 5358, 5360, 5367, 5368, 5390, 5404, 5409, 5410, 5413, 5538, and 5465 DVD, depending on availability)
6161
Highly Efficient Lipoparticle Capture and SPR Binding Kinetics of a Membrane Protein Using the ProteOn XPR36 Protein Interaction Array System, Rev A
6449
Novel Liposome-Capture Surface Chemistries to Analyze Drug-Lipid Interaction using the ProteOn XPR36 System, Rev A
6414
ProteOn™ XPR36 Experimental Design and Application Guide, Rev B