Nuvia cPrime Media

Nuvia cPrime Media

Nuvia cPrime Resin is a weak cation exchange – hydrophobic interaction (CEX-HIC) mixed-mode media designed for versatile capture and high recovery across a wide range of salt concentrations and pH in process-scale purification processes for biotherapeutic applications.

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Overview

Nuvia cPrime weak cation exchange – hydrophobic interaction (CEX-HIC) mixed-mode media is designed for laboratory- and process-scale purification of a wide variety of therapeutic proteins. Nuvia cPrime media's unique selectivity allows method developers to use hydrophobic and cation exchange interaction modes to achieve effective purification. More importantly, the media have a large design space for binding and elution, allowing for the development of highly robust methods in a commercial manufacturing setting. Nuvia cPrime media are built on a rigid, mechanically and chemically stable macroporous base matrix with a particle size optimized to deliver exceptional flow properties, fast mass transfer, and stability.

Nuvia cPrime delivers value by providing:

  • New and unique selectivity
  • Salt tolerant media
  • Simple method development
  • Large design space for capture and elution of a variety of biotherapeutic proteins
  • High recovery of target protein
  • Mechanical and chemical stability

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Specifications

Functional group
Hydrophobic weak cation exchange
Base matrix composition
Macroporous highly crosslinked polymer
Particle size
70 µm ± 10 µm
Dynamic binding capacity
hlgG: >40 mg/ml (at 10% breakthrough, 300 cm/hr)
Lactoferrin: >60 mg/ml
Ligand density
103–143 µeq/ml
Recommended maximum linear flow rate
50–600 cm/hr
Pressure vs. flow performance
Under 2 bar at a flow rate of 600 cm/hr
(20 cm × 20 cm packed bed; 1.17 comp. factor)
pH stability short-term
2–14
pH stability long-term
3–13
Chemical stability
1.0 N NaOH, 1.0 N HCl, 25% HOAc, 8 M urea, 6 M GuHCl, 6 M KSCN, 3 M NaCl, 1% octylphenol ethoxylate, 2% SDS + 0.25 M NaCl, 20% EtOH, 70% EtOH, 30% IPA
Shipping solution
All volumes are available in 20% ethanol + 30 mM sodium sulfite. Volumes of 500 ml or more are also available in 2% benzyl alcohol (BA).
Storage conditions
20% ethanol
Shelf life in 20% ethanol
5 years at room temperature

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items

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7324705
2 x 96-well plates, 20 μl, filter plate prepacked with Nuvia cPrime Hydrophobic Cation Exchange Chromatography Media
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7324807
1 row of 8 columns, 200 μl, RoboColumn unit prepacked with Nuvia cPrime Hydrophobic Cation Exchange Chromatography Media
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7324808
1 row of 8 columns, 600 μl, RoboColumn unit prepacked with Nuvia cPrime Hydrophobic Cation Exchange Chromatography Media
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7324722
Pkg of 1, 1 ml, column prepacked with Nuvia cPrime Hydrophobic Cation Exchange Chromatography Media
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7324742
Pkg of 1, 5 ml, column prepacked with Nuvia cPrime Hydrophobic Cation Exchange Chromatography Media
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12009281

Pkg of 1, 1 ml, prepacked hydrophobic cation exchange column, 7 mm x 25 mm, max. pressure 45 psi, for use with NGC Systems or any chromatography system

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