Nuvia Q Resin

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Overview

Nuvia Q is an ultra-high binding capacity anion exchange resin with wide pH and flow rate working ranges ideal for process development. It is the next-generation ion exchange resin of choice for biosimilars, delivering high-concentrated product.

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Description

Description

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Nuvia Q Resin is an ultra-high capacity, next-generation anion exchange resin. Nuvia Q Resin delivers high binding capacity over a range of pH and flow rates, providing a wide experimental design space for process developers. This exceptional binding capacity makes Nuvia Q the anion exchanger of choice for biopharmaceuticals as upstream processes deliver higher concentrations of feed titers.

Along with high binding capacity, Nuvia Q Resin also delivers excellent performance for polishing applications. Nuvia Q Resin can significantly improve productivity while contributing to reduced capital costs, space requirements, and cycle time for downstream biotherapeutic purification.

Nuvia Q Resin delivers value and flexibility by providing users:

  • Best-in-class binding capacity at fast flow rates
  • Rapid mass transfer kinetics
  • Efficient resolution of biomolecules from crude feedstreams
  • Robust media design providing competitive NaOH stability
  • Full regulatory support

More Information

Nuvia Q Anion Exchange Resin Product Information Sheet (Bulletin 6129)

Instruction Manual, Nuvia S and Q High-Capacity Ion Exchange Resins (10018215)

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Specifications

Specifications

Type of ion exchanger
Strong anion
Functional group
–N(CH3)3+
Total ionic capacity
100–170 µeq/ml
Dynamic binding capacity*: 300 cm/hr
≥170 mg/ml
Shipping counterion
CI
Median particle size
85 ± 15 µm
Operational flow rate**
50–600 cm/hr
Chemical stability: 1.0 N NaOH (20°C)
Up to 1 week
Chemical stability: 0.01 N NaOH (20°C)***
Up to 5 years
Gel bed compression ratio
1.10–1.15
pH stability short-term***
2-14
pH stability long-term***
4–12
Shipping solution
20% ethanol + 1 M NaCl
Regeneration
1–2 M NaCl
Sanitation
0.5–1.0 N NaOH
Storage conditions
20% ethanol or 0.01 N NaOH
* 10% breakthrough capacity determined with 5 mg/ml BSA in 20 mM Tris-HCI, pH 8.5.
 
** Recommended elution flow rates are ≤ 150 cm/hr to minimize viscosity-induced backpressure.
 
*** Data derived under accelerated conditions at 60°C.
 

Ordering

Ordering

items

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7324804
1 row of 8 columns, 200 μl, RoboColumn unit prepacked with Nuvia Q Strong Anion Exchange Chromatography Media
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7324805
1 row of 8 columns, 600 μl, RoboColumn unit prepacked with Nuvia Q Strong Anion Exchange Chromatography Media
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Nuvia Q Media
(Discontinued) Nuvia Q Media
1560411

25 ml, strong anion exchange chromatography media, 85 µm particle size

Accessories

Accessories

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7320113

Low-pressure system fittings kit, includes 1/4–28 female to male and 1/4–28 female to female luers to connect 1 cartridge to BioLogic DuoFlow and NGC Systems

Documents

Documents

Number Description Options
3218
A Blueprint for Robust, Cost- Efficient Biosimilar Purification Using Ion Exchange Resins
6129
Nuvia Q Anion Exchange Resin Product Information Sheet
10018215
Instruction Manual, Nuvia S and Q High-Capacity Ion Exchange Media
6895
Resin Functionalities Maximize Process Value For Biomolecule Purifications
[ Add to Cart (Free) ]
7200
Low-Cost, Fast, and Scalable Downstream Purification Process Development for a Clinical-Stage Retrovirus-Like Particle, Ver A
7130
Improved Process Economics of HUMIRA Biosimilar Purification with Ion Exchange and Mixed-Mode Resins Application Note
7382
Purification of a Recombinant Monoclonal Antibody — a Rituximab Biosimilar — with a Non–Affinity Based Chromatographic Process
6983
Native and Recombinant Protein Purification Resins/Media Selection Card
6786
Monoclonal Antibody Purification Resin Selection Card, Ver A
6789
IgG Polyclonal Antibody Purification Resin Selection Card, Ver A
6791
Virus Purification Resin Selection Card, Ver A
6711
Purification of Amyloidogenic Transthyretin Protein Using Nuvia™ Q Anion Exchange Resin, Rev A
6719
Development of an Efficient Manufacturing Process for Adenovirus, Ver A
6720
Development of a cGMP-Ready Purification Process for Adenovirus Purification (Poster), Rev A
6770
Automated mAb Workflows: Combining Multidimensional (Multi-D) Purifications with Product Analysis (Poster), Ver A
6875
Practical Guide: Selecting the Optimal Resins for Monoclonal Antibody Process Purification, Ver A
6810
Practical Guide: Selecting the Optimal Resins for the Process Purification of Native and Recombinant Proteins, Ver A
6813
Practical Guide: Selecting the Optimal Resins for Endotoxin Depletion in Process Purification, Ver A
6807
Practical Guide: Selecting the Optimal Resins for Adenovirus Process Purification, Ver A
6790
Practical Guide: Selecting the Optimal Resins for Mammalian Virus Process Purification and Clearance, Ver A
6881
Practical Guide: Selecting the Optimal Resins for Removal of DNA Contamination during Process Purification, Ver A
6889
Novel Selectivities and Workflows to Streamline mAb Purification Processes, Ver A
6869
Nuvia™ Chromatography Resins Publications List, Ver A
6862
Monoclonal Antibody Purification: Intermediate Purification Resins Brochure, Ver A
6887
Quick Monoclonal Antibody Purification Strategy: Non-Affinity Based Capture Flier, Ver A
6880
Quick Virus Purification Strategy: Adenovirus Purification Flier, Ver A