Nuvia Q Resin

Nuvia Q Resin

Nuvia Q is an ultra-high binding capacity anion exchange resin with wide pH and flow rate working ranges ideal for process development. It is the next-generation ion exchange resin of choice for biosimilars, delivering high-concentrated product.

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Overview

Nuvia Q Resin is an ultra-high capacity, next-generation anion exchange resin. Nuvia Q Resin delivers high binding capacity over a range of pH and flow rates, providing a wide experimental design space for process developers. This exceptional binding capacity makes Nuvia Q the anion exchanger of choice for biopharmaceuticals as upstream processes deliver higher concentrations of feed titers.

Along with high binding capacity, Nuvia Q Resin also delivers excellent performance for polishing applications. Nuvia Q Resin can significantly improve productivity while contributing to reduced capital costs, space requirements, and cycle time for downstream biotherapeutic purification.

Nuvia Q Resin delivers value and flexibility by providing users:

  • Best-in-class binding capacity at fast flow rates
  • Rapid mass transfer kinetics
  • Efficient resolution of biomolecules from crude feedstreams
  • Robust media design providing competitive NaOH stability
  • Full regulatory support

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Specifications

Type of ion exchanger
Strong anion
Functional group
–N(CH3)3+
Total ionic capacity
100–170 µeq/ml
Dynamic binding capacity*: 300 cm/hr
≥170 mg/ml
Shipping counterion
CI
Median particle size
85 ± 15 µm
Operational flow rate**
50–600 cm/hr
Chemical stability: 1.0 N NaOH (20°C)
Up to 1 week
Chemical stability: 0.01 N NaOH (20°C)***
Up to 5 years
Gel bed compression ratio
1.10–1.15
pH stability short-term***
2-14
pH stability long-term***
4–12
Shipping solution
20% ethanol + 1 M NaCl, or 2% benzyl alcohol (BA)
Regeneration
1–2 M NaCl
Sanitation
0.5–1.0 N NaOH
Storage conditions
20% ethanol or 0.01 N NaOH
* 10% breakthrough capacity determined with 5 mg/ml BSA in 20 mM Tris-HCI, pH 8.5.
 
** Recommended elution flow rates are ≤ 150 cm/hr to minimize viscosity-induced backpressure.
 
*** Data derived under accelerated conditions at 60°C.
 

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Nuvia Q Media
(Discontinued) Nuvia Q Media
1560411

25 ml, strong anion exchange chromatography media, 85 µm particle size

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7324703
2 x 96-well plates, 20 μl, filter plate prepacked with Nuvia Q Strong Anion Exchange Chromatography Media
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7324804
1 row of 8 columns, 200 μl, RoboColumn unit prepacked with Nuvia Q Strong Anion Exchange Chromatography Media
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7324805
1 row of 8 columns, 600 μl, RoboColumn unit prepacked with Nuvia Q Strong Anion Exchange Chromatography Media
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12009290

Pkg of 1, 1 ml, prepacked anion exchange column, 7 mm x 25 mm, max. pressure 45 psi, for use with NGC Systems or any chromatography system

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