Nuvia S Resin

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Overview

Nuvia S is an ultra-high capacity, next-generation cation exchange resin built on the industry-proven UNOsphere™ base matrix technology. Nuvia S resin may be used in both the capture and polishing of biotherapeutics.

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Description

Description

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Nuvia S Resin is an ultra-high capacity, next-generation cation exchange resin built on the industry proven UNOsphere™ base matrix technology. Nuvia S Resin provides very high capture and exceptional flow properties designed to meet current and future process needs. Nuvia S Resin is a flexible alternative that may be used both as a capture or polishing solution. The media delivers superior binding capacity over a wide operational window, making it the tool of choice for a wide range of downstream processes.

Nuvia S Resin delivers value and flexibility by allowing users to:

  • Use less media to purify a given amount of product
  • Reduce cycle time and increase productivity by operating at higher flow rates
  • Reduce costs and space requirements by decreasing buffer consumption
  • Reduce capital and operating expenses through the use of smaller columns
  • Chemical stability to withstand repetitive clean-in-place cycles
  • Flexibility in use for capture or polish steps
  • Fully supported for regulatory submission

More Information

Nuvia S Cation Exchange Resin Product Information Sheet Bulletin 5987

Instruction Manual, Nuvia S and Q High-Capacity Ion Exchange Resins 10018215

Specifications

Specifications

Type of ion exchanger
Strong cation
Functional group
–SO3
Total ionic capacity
90–150 µeq/ml
Dynamic binding capacity*: 300 cm/hr
≥110 mg/ml
Shipping counterion
Na+
Median particle size
85 ± 15 µm
Operational flow rate**
50–600 cm/hr
Chemical stability: 1.0 N NaOH (20ºC)
Up to 1 week
Chemical stability: 0.1 N NaOH (20ºC)***
Up to 5 years
Gel bed compression ratio
1.15–1.18 (settled bed volume/packed bed volume)
pH stability short-term***
2–14
pH stability long-term***
4–13
Shipping solution
20% ethanol + 0.1 M NaCl
Regeneration
1–2 M NaCl
Sanitation
0.5–1.0 N NaOH
Storage conditions
20% ethanol or 0.1 N NaOH
 
 
* 10% breakthrough capacity determined with 4.5 mg/ml human
IgG in 40 mM NaOAc + 30 mM NaCl, pH 5.0.
 
** Recommended elution flow rates are ≤ 150 cm/hr to minimize viscosity-induced backpressure.
 
*** Data derived under accelerated conditions at 60°C.
 

Ordering

Ordering

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7324801
1 row of 8 columns, 200 μl, RoboColumn unit prepacked with Nuvia S Strong Cation Exchange Chromatography Media
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7324802
1 row of 8 columns, 600 μl, RoboColumn unit prepacked with Nuvia S Strong Cation Exchange Chromatography Media

Documents

Documents

Number Description Options
3218
A Blueprint for Robust, Cost- Efficient Biosimilar Purification Using Ion Exchange Resins
6895
Resin Functionalities Maximize Process Value For Biomolecule Purifications
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7130
Improved Process Economics of HUMIRA Biosimilar Purification with Ion Exchange and Mixed-Mode Resins Application Note
7134
A Non-Affinity Chromatography Resin Alternative for Capture Purification of Antibodies Application Note
5987
Nuvia S Cation Exchange Media Product Information Sheet
10018215
Instruction Manual, Nuvia S and Q High-Capacity Ion Exchange Media
7382
Purification of a Recombinant Monoclonal Antibody — a Rituximab Biosimilar — with a Non–Affinity Based Chromatographic Process
6242
Nuvia™ cPrime™ Hydrophobic Cation Exchange Resin Product Information Sheet, Rev C
6983
Native and Recombinant Protein Purification Resins/Media Selection Card
6786
Monoclonal Antibody Purification Resin Selection Card, Ver A
6789
IgG Polyclonal Antibody Purification Resin Selection Card, Ver A
6792
Aggregate Purification Resin Selection Card, Ver A
6966
Development of a Non–Affinity Based Purification Platform for Neutral/Basic IgMs
6955
Non–Affinity Based Purification Platform for Neutral/Basic IgMs (Poster)
6711
Purification of Amyloidogenic Transthyretin Protein Using Nuvia™ Q Anion Exchange Resin, Rev A
6720
Development of a cGMP-Ready Purification Process for Adenovirus Purification (Poster), Rev A
RP0049
The Effect of Conductivity on Dynamic Binding Capacity on CEX Resins Tech Poster, Rev A.
6719
Development of an Efficient Manufacturing Process for Adenovirus, Ver A
6875
Practical Guide: Selecting the Optimal Resins for Monoclonal Antibody Process Purification, Ver A
6810
Practical Guide: Selecting the Optimal Resins for the Process Purification of Native and Recombinant Proteins, Ver A
6808
Practical Guide: Selecting the Optimal Resins for Aggregate Removal, Ver A
6790
Practical Guide: Selecting the Optimal Resins for Mammalian Virus Process Purification and Clearance, Ver A
6881
Practical Guide: Selecting the Optimal Resins for Removal of DNA Contamination during Process Purification, Ver A
6889
Novel Selectivities and Workflows to Streamline mAb Purification Processes, Ver A
6869
Nuvia™ Chromatography Resins Publications List, Ver A
6861
Monoclonal Antibody Purification: Capture Purification Resins Brochure, Ver A
6887
Quick Monoclonal Antibody Purification Strategy: Non-Affinity Based Capture Flier, Ver A