Binding of polyclonal human IgG by Nuvia S media. Comparison of Nuvia S and other commercially available CEX media. Column size, 0.7 x 5.5 cm. The sample was loaded onto the column in 40 mM sodium acetate, pH 5.0 and 30 mM sodium chloride, washed, and eluted with 40 mM sodium acetate, pH 5.0 and 1 M sodium chloride.
DBC, Dynamic Binding Capacity. BT, Breakthrough
Ultra-high binding capacities provide users with the maximum value through reduced media and buffer consumption, when used in both capture and polish mode.
Nuvia™ Q and S Ultra-High Capacity Ion Exchange Media
Bio-Rad now offers two ultra-high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing, and Nuvia Q, which can be used for intermediate and/or final polishing.
Binding of a monoclonal antibody (mAb) by Nuvia S media. Column size, 1.1 cm x 10 cm; sample, 4.5–5.0 mg/ml mAb, was loaded onto the column in 20 mM sodium acetate, pH 5.0 + sodium chloride (adjusted for conductivity) until 5% and 10% breakthrough capacity were observed.
Dynamic binding capacity (DBC) vs. flow velocity. A 1.1 cm diameter column was packed to a 20 cm bed height with Nuvia S media. 4.5 mg/ml human polyclonal IgG in 40 mM sodium acetate and 30 mM sodium chloride, pH 5.0 was loaded until 10% breakthrough was observed.
Stability of Nuvia S media. Results from an accelerated storage study (in 1.0 M NaOH) show no loss in dynamic binding capacity and recovery.
Base-Stability, Consistent Performance The chemical stability of Nuvia S media allows the media to withstand repeated exposure to commonly used sanitization and clean-in-place protocols. Nuvia S media exposed to 840 hr of 1.0 M NaOH with typically used cleaning cycles showed no decreases of dynamic binding capacity or recovery. Nuvia S media delivers value and process stability by maintaining peak performance over an extended life.
Nuvia S is an ultra-high capacity, next-generation cation exchange resin built on the industry-proven UNOsphere™ base matrix technology. Nuvia S resin may be used in both the capture and polishing of biotherapeutics. Read full description
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