Nuvia S Resin

Print
Nuvia S Resin

Overview

Media Comparison: Dynamic Binding Capacity

 

 

Binding of polyclonal human IgG by Nuvia S media. Comparison of Nuvia S and other commercially available CEX media. Column size, 0.7 x 5.5 cm. The sample was loaded onto the column in 40 mM sodium acetate, pH 5.0 and 30 mM sodium chloride, washed, and eluted with 40 mM sodium acetate, pH 5.0 and 1 M sodium chloride.

DBC, Dynamic Binding Capacity. BT, Breakthrough

Ultra-high binding capacities provide users with the maximum value through reduced media and buffer consumption, when used in both capture and polish mode.

For more information click here.

Nuvia™ Q and S Ultra-High Capacity Ion Exchange Media

Bio-Rad now offers two ultra-high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing, and Nuvia Q, which can be used for intermediate and/or final polishing.

Best-in-Class Dynamic Binding Capacity

 


 

Binding of a monoclonal antibody (mAb) by Nuvia S media. Column size, 1.1 cm x 10 cm; sample, 4.5–5.0 mg/ml mAb, was loaded onto the column in 20 mM sodium acetate, pH 5.0 + sodium chloride (adjusted for conductivity) until 5% and 10% breakthrough capacity were observed.

For more information click here.

Nuvia S Superior Flow Properties

 

Nuvia

 

Dynamic binding capacity (DBC) vs. flow velocity. A 1.1 cm diameter column was packed to a 20 cm bed height with Nuvia S media. 4.5 mg/ml human polyclonal IgG in 40 mM sodium acetate and 30 mM sodium chloride, pH 5.0 was loaded until 10% breakthrough was observed.

Nuvia S Media Chemical Stability

 


 

Stability of Nuvia S media. Results from an accelerated storage study (in 1.0 M NaOH) show no loss in dynamic binding capacity and recovery.

Base-Stability, Consistent Performance
The chemical stability of Nuvia S media allows the media to withstand repeated exposure to commonly used sanitization and clean-in-place protocols. Nuvia S media exposed to 840 hr of 1.0 M NaOH with typically used cleaning cycles showed no decreases of dynamic binding capacity or recovery. Nuvia S media delivers value and process stability by maintaining peak performance over an extended life.

Nuvia S is an ultra-high capacity, next-generation cation exchange resin built on the industry-proven UNOsphere™ base matrix technology. Nuvia S resin may be used in both the capture and polishing of biotherapeutics.
Read full description

Ordering Information


Description

Request Samples

Nuvia S Resin is an ultra-high capacity, next-generation cation exchange resin built on the industry proven UNOsphere™ base matrix technology. Nuvia S Resin provides very high capture and exceptional flow properties designed to meet current and future process needs. Nuvia S Resin is a flexible alternative that may be used both as a capture or polishing solution. The media delivers superior binding capacity over a wide operational window, making it the tool of choice for a wide range of downstream processes.

Nuvia S Resin delivers value and flexibility by allowing users to:
  • Use less media to purify a given amount of product
  • Reduce cycle time and increase productivity by operating at higher flow rates
  • Reduce costs and space requirements by decreasing buffer consumption
  • Reduce capital and operating expenses through the use of smaller columns
  • Chemical stability to withstand repetitive clean-in-place cycles
  • Flexibility in use for capture or polish steps
  • Fully supported for regulatory submission

More Information

Nuvia S Cation Exchange Resin Product Information Sheet Bulletin 5987

Instruction Manual, Nuvia S and Q High-Capacity Ion Exchange Resins 10018215


Specifications

Type of ion exchanger Strong cation
Functional group –SO3
Total ionic capacity 90–150 µeq/ml
Dynamic binding capacity*: 300 cm/hr ≥110 mg/ml
Shipping counterion Na+
Median particle size 85 ± 15 µm
Operational flow rate** 50–600 cm/hr
Chemical stability: 1.0 N NaOH (20ºC) Up to 1 week
Chemical stability: 0.1 N NaOH (20ºC)*** Up to 5 years
Gel bed compression ratio 1.15–1.18 (settled bed volume/packed bed volume)
pH stability short-term*** 2–14
pH stability long-term*** 4–13
Shipping solution 20% ethanol + 0.1 M NaCl
Regeneration 1–2 M NaCl
Sanitation 0.5–1.0 N NaOH
Storage Conditions 20% ethanol or 0.1 N NaOH
   
* 10% breakthrough capacity determined with 4.5 mg/ml human
IgG in 40 mM NaOAc + 30 mM NaCl, pH 5.0.
 
** Recommended elution flow rates are ≤ 150 cm/hr to minimize viscosity-induced backpressure.  
*** Data derived under accelerated conditions at 60°C.  

Ordering

x

Account price failed to display. Please try reloading the page.Reload Page

If you are placing an order, you may proceed with your order; the account price will be applied if it is lower than the
list price. If the problem persists, please call customer service at or send an
email to

Nuvia™ S Media

1560311
25 ml, strong cation exchange chromatography media, 85 μm particle size

List Price: 
 
$115.00 
LoadingLoading...
EDU Price:
 
What is this?
Your Price: 
 
LoadingLoading...
Your Price:
 

Communication error

Reload Page

Quantity:   Add to Cart
 
Nuvia™ S Media

1560313
100 ml, strong cation exchange chromatography media, 85 μm particle size

List Price: 
 
$355.00 
LoadingLoading...
EDU Price:
 
What is this?
Your Price: 
 
LoadingLoading...
Your Price:
 

Communication error

Reload Page

Quantity:   Add to Cart
 
Nuvia™ S Media

156-0315
500 ml, strong cation exchange chromatography media, 85 μm particle size

List Price: 
 
Inquire
LoadingLoading...
EDU Price:
 
What is this?
Your Price: 
 
LoadingLoading...
Your Price:
 

Communication error

Reload Page

Quantity:   Add to Cart
 
Nuvia™ S Media

156-0317
10 L , strong cation exchange chromatography media, 85 μm particle size

List Price: 
 
Inquire
LoadingLoading...
EDU Price:
 
What is this?
Your Price: 
 
LoadingLoading...
Your Price:
 

Communication error

Reload Page

Quantity:   Add to Cart
 
Foresight™ Nuvia™ S Plates

7324701
2 x 96-well plates, 20 μl, filter plate prepacked with Nuvia S Strong Cation Exchange Chromatography Media

List Price: 
 
$860.00 
LoadingLoading...
EDU Price:
 
What is this?
Your Price: 
 
LoadingLoading...
Your Price:
 

Communication error

Reload Page

Quantity:   Add to Cart
 
Foresight™ Nuvia™ S RoboColumn Unit

7324801
1 row of 8 columns, 200 μl, RoboColumn unit prepacked with Nuvia S Strong Cation Exchange Chromatography Media

List Price: 
 
$350.00 
LoadingLoading...
EDU Price:
 
What is this?
Your Price: 
 
LoadingLoading...
Your Price:
 

Communication error

Reload Page

Quantity:   Add to Cart
 
Foresight™ Nuvia™ S RoboColumn Unit

7324802
1 row of 8 columns, 600 μl, RoboColumn unit prepacked with Nuvia S Strong Cation Exchange Chromatography Media

List Price: 
 
$420.00 
LoadingLoading...
EDU Price:
 
What is this?
Your Price: 
 
LoadingLoading...
Your Price:
 

Communication error

Reload Page

Quantity:   Add to Cart
 
Foresight™ Nuvia™ S Column

7324720
Pkg of 1, 1 ml, column prepacked with Nuvia S Strong Cation Exchange Chromatography Media

List Price: 
 
$195.00 
LoadingLoading...
EDU Price:
 
What is this?
Your Price: 
 
LoadingLoading...
Your Price:
 

Communication error

Reload Page

Quantity:   Add to Cart
 
Foresight™ Nuvia™ S Column

7324740
Pkg of 1, 5 ml, column prepacked with Nuvia S Strong Cation Exchange Chromatography Media

List Price: 
 
$350.00 
LoadingLoading...
EDU Price:
 
What is this?
Your Price: 
 
LoadingLoading...
Your Price:
 

Communication error

Reload Page

Quantity:   Add to Cart
 

Documents

Number Description Options
6895 Resin Functionalities Maximize Process Value For Biomolecule Purifications Click to download [ Add to Cart (Free) ]
7130 Improved Process Economics of HUMIRA Biosimilar Purification with Ion Exchange and Mixed-Mode Resins Application Note Click to download
7134 A Non-Affinity Chromatography Resin Alternative for Capture Purification of Antibodies Application Note, Ver A Click to download
7382 Purification of a Recombinant Monoclonal Antibody — a Rituximab Biosimilar — with a Non–Affinity Based Chromatographic Process Click to download
6242 Nuvia™ cPrime™ Hydrophobic Cation Exchange Resin Product Information Sheet, Rev C Click to download [ Add to Cart (Free) ]
6983 Native and Recombinant Protein Purification Resins/Media Selection Card Click to download
6786 Monoclonal Antibody Purification Resin Selection Card, Ver A Click to download
6789 IgG Polyclonal Antibody Purification Resin Selection Card, Ver A Click to download
6792 Aggregate Purification Resin Selection Card, Ver A Click to download
6966 Development of a Non–Affinity Based Purification Platform for Neutral/Basic IgMs Click to download
6955 Non–Affinity Based Purification Platform for Neutral/Basic IgMs (Poster) Click to download
6711 Purification of Amyloidogenic Transthyretin Protein Using Nuvia™ Q Anion Exchange Resin, Rev A Click to download
6720 Development of a cGMP-Ready Purification Process for Adenovirus Purification (Poster), Rev A Click to download
RP0049 The Effect of Conductivity on Dynamic Binding Capacity on CEX Resins Tech Poster, Rev A. Click to download
6719 Development of an Efficient Manufacturing Process for Adenovirus, Ver A Click to download
6875 Practical Guide: Selecting the Optimal Resins for Monoclonal Antibody Process Purification, Ver A Click to download
6810 Practical Guide: Selecting the Optimal Resins for the Process Purification of Native and Recombinant Proteins, Ver A Click to download
6808 Practical Guide: Selecting the Optimal Resins for Aggregate Removal, Ver A Click to download
6790 Practical Guide: Selecting the Optimal Resins for Mammalian Virus Process Purification and Clearance, Ver A Click to download
6881 Practical Guide: Selecting the Optimal Resins for Removal of DNA Contamination during Process Purification, Ver A Click to download
6889 Novel Selectivities and Workflows to Streamline mAb Purification Processes, Ver A Click to download
6869 Nuvia™ Chromatography Resins Publications List, Ver A Click to download
6861 Monoclonal Antibody Purification: Capture Purification Resins Brochure, Ver A Click to download
6887 Quick Monoclonal Antibody Purification Strategy: Non-Affinity Based Capture Flier, Ver A Click to download

This product contains electrical or electronic material. Learn more about Bio-Rad's EU Recycle Program

Get Help
Related Products
Sign Up for Bio-Rad Updates!
Enter your email address below to receive your choice of the latest news, promotions, and more.