ChromLab Software

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ChromLab Software is the integrated software package for the NGC Chromatography System. It controls all functions for laboratory-scale protein purification including instrument setup and calibration, method development, real-time monitoring and system control, chromatogram comparison, and peak analysis.

Graphical Instrument Control

ChromLab Software instrument controls are designed around a novel fluidic scheme interface, which is customizable to the exact hardware configuration. In the case of multiple valves of the same type, the user can map the physical location of the device to its location in the fluidics scheme. During manual data acquisition, each component of the fluidic scheme can be controlled, providing the flexibility to edit on the fly and optimize purification conditions. When operating the automated, programmed method mode, the flow rate, the gradient, and fractionation can all be edited and redefined rapidly for ultimate flexibility. In both manual and automated method-based runs, the software highlights the real-time fluidic path and module device status to ensure accuracy.

The instrument control interface is also touch-screen optimized, allowing the same level of flexibility without the need for a computer adjacent to the system, while minimizing the total footprint. This interface is also fully configured with VNC (Virtual Network Computing), allowing you to control and monitor the system remotely from nearly any smartphone, tablet, or laptop.

Learn how ChromLab Software allows you to set up and control your NGC System with ease.

Streamlined Method Development

ChromLab Software includes templates for common chromatography methods and complete multistep tandem chromatography for maximum versatility. Select your column from our column database, and ChromLab Software will automatically adjust the flow rate and pressure parameters to the optimal values for that column, preventing damage to the column. For maximum flexibility, you can create your own custom column database entries.

Methods are created based on functional phases. Grouping parameters into intuitive phases puts the focus on your separations instead of hardware controls. The interactive gradient graph enables visualization of the protocol and quick click-and-drag adjustments to the experiment.

Optimize your fractionation by choosing different collection triggers such as slope, pH, %B, and detector signals.

Optimization of each method is a required step prior to automating multistep purification. The Scouting Wizard in ChromLab Software helps determine optimal purification conditions in an automated, systematic manner. Scout one parameter at a time or multiple variables. In one method, screen up to 384 samples while scouting different sample volumes, columns, buffers, flow rates, or elution profiles.

Automated Multicolumn Purification Techniques

The software contains three tandem and 2D purification templates that reflect common multicolumn purification scenarios. These templates may be edited to fit specific use case requirements. The following videos give an overview of how tandem purification can be applied to your research and reduce hands-on time.

Use ChromLab Software for automated sequential purification, tandem purification, and 2-D purification.

Intuitive Data Evaluation

ChromLab Software utilizes intuitive functions and advanced tabular controls that enable:

• Customizable chromatogram layouts with a variety of viewing and data analysis options
• Rapid creation of trace comparisons between multiple chromatograms
• Single-click peak detection and integration
• Advanced integration parameters for manual integration functions and peak addition or removal for fine-tuning your data
• Organized data and easy navigation with intuitive, grouped tabular layouts
• Visual tracking of your peak from fraction to fraction with rack location
• Heat maps for easy visualization of fraction concentration and purity
• Automated calculation of common characteristics; for example, HETP or peak symmetry for rapid assessment of column health
• Molecular weight determination of proteins with a designated SEC calibration curve.

Simplify the evaluation of protein purification data with ChromLab Software.

Features and Benefits of ChromLab Software

• Use of the touch screen allows the same level of flexibility without the need for a computer adjacent to the system, minimizing the total footprint
• Customizable chromatogram layouts with a variety of viewing and data analysis options
• Edit on the fly during manual or method mode
• Rapid creation of trace comparisons allows easy analysis across multiple purification runs
• Single-click peak detection and integration for quicker results
• Advanced integration parameters enable manual integration functions and peak addition or removal for fine-tuning your data
• Intuitive, grouped data. Tabular layouts organize data for easy navigation
• Lock in your preferences for units of measure, fraction collector rack types, and analysis to increase purification efficiency
• Multisystem control from a single PC for a smaller lab footprint
• Automated optimization and multistep purification

Applications and Uses of ChromLab Software

• Controls all functions of the NGC Medium-Pressure Chromatography System for lab-scale protein purification
• Instrument control
• Data storage on a centralized database with the User Management Edition
• Method development to identify best methods
• Real-time monitoring of proteins, peptides, nucleic acids, and chromophores
• Chromatogram comparison and peak analysis

ChromLab Software, Security Edition

For users in regulated environments, ChromLab Software, Security Edition is available to allow operation of the NGC Chromatography System in compliance with Title 21 of the U.S. Code of Federal Regulations Part 11 (21 CFR Part 11).

Supporting Documents

Documentation for ChromLab Software Standard Edition, which covers instrument use and standard software features, is available compiled on the same USB flash drive that contains ChromLab Software (12009390), provided with all NGC Chromatography Systems.

Alternatively, download the individual PDFs below:

• NGC Systems and ChromLab Software Guides:
  • User Guide
  • Instrument Guide
  • Installation Guide
• ChromLab Software, User Management Edition User Guide
• ChromLab Software, Security Edition User Guide

Documentation for ChromLab Software Security Edition is provided when purchasing the software licenses.