Nuvia HP-Q Resin
Nuvia HP-Q Anion Exchange Resin is a high-capacity ion exchange resin that can be used for downstream purification of large molecules such as high molecular weight (HMW) plasma proteins IgA and IgM, viruses, VLPs, and PEGylated proteins.
Overview
Nuvia HP-Q is a high-performance strong anion exchange resin. It is the latest product in the Nuvia family of high-capacity ion exchange resins and can be used for downstream purification of large molecules such as high molecular weight (HMW) plasma proteins IgA and IgM, viruses, VLPs, and PEGylated proteins. The stability of this base bead and its broad chemical compatibility allows repeated uses with a long resin lifetime. Nuvia HP-Q particle size is designed to offer high dynamic binding capacity (DBC) at fast flow rates without excessive backpressure, thereby delivering excellent process economics. Its pore size is optimized for easy accessibility and adsorption of large biomolecules, and the internal spacer length and ligand density facilitate efficient binding of the biomolecules even at high flow rates.
Features and Benefits
- Ideal for purification of large biomolecules
- Excellent pressure flow properties
- Recover more target biomolecule with less resin
- Increase productivity and decrease cycle time with high flow rates
- Easily scalable to meet manufacturing demands
- Improve overall process economics
Large Molecule Applications
- Plasma proteins IgA and IgM
- Viruses
- VLPs
- PEGylated proteins
Superior DBC of Nuvia HP-Q at a High Flow Rate Relative to Other Commercially Available Resins.
IgM obtained from plasma fractionation showed DBC in the range of 20-25 mg/ml with Nuvia HP-Q Resin. When compared to other commercially available resins, Nuvia HP-Q Resin demonstrated higher DBC at faster flow rates.
| Vendor/Product | Matrix Material | Particle Size, µm | Pressure, bar | Recommended Flow Rate, cm/hr1 | DBC (IgM) |
| Nuvia HP-Q | UNOsphere | 50 | <3 | 300 | +++2 |
| Resin 1 | Dextran beads | 50 | <3 | 30 | +++2 |
| Resin 2 | Agarose | 75 | <3 | 300 | +3 |
| Resin 3 | PS/DVB | 50 | <3 | 300 | +2 |
| Resin 4 | PMMA | 50 | <2 | 300 | +2 |
1 Recommended flow rate for industrial scale column (D > 30 cm).
2 DBC data at 10% breakthrough
3 Data obtained from vendor presentation.
Product Formats
| Product | Catalog Number |
| Nuvia HP-Q Media, 25 ml | 12006693 |
| Nuvia HP-Q Media, 100 ml | 12006691 |
| Nuvia HP-Q Media, 500 ml | 12006660 |
| Nuvia HP-Q Media, 5 L | 12006659 |
| Nuvia HP-Q Media, 10 L | 12007023 |
Screening Tools
Foresight™ Nuvia HP-Q Column, 1 ml
12007020
Foresight Nuvia HP-Q Column, 5 ml
12007021
Foresight Nuvia HP-Q RoboColumn Unit, 200 μl
12007013
Foresight Nuvia HP-Q RoboColumn Unit, 600 μl
12007014
Foresight Nuvia HP-Q Plates, 20 μl
12006908
More Information
- Nuvia HP-Q Product Information Sheet
- Nuvia HP-Q Instruction Manual
Specifications
Ordering
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25 ml, strong anion exchange chromatography media, 50 µm particle size
100 ml, strong anion exchange chromatography media, 50 µm particle size
500 ml, strong anion exchange chromatography media, 50 µm particle size
500 ml, strong anion exchange chromatography media, 50 µm particle size, shipped in 2% benzyl alcohol
5 L, strong anion exchange chromatography media, 50 µm particle size
5 L, strong anion exchange chromatography media, 50 µm particle size, shipped in 2% benzyl alcohol
10 L, strong anion exchange chromatography media, 50 µm particle size
10 L, strong anion exchange chromatography media, 50 µm particle size, shipped in 2% benzyl alcohol
Pkg of 1, 1 ml, prepacked anion exchange column, 7 mm x 25 mm, max. pressure 45 psi, for use with NGC Systems or any chromatography system