Nuvia HP-Q is a high-performance strong anion exchange resin. It is the latest product in the Nuvia family of high-capacity ion exchange resins and can be used for downstream purification of large molecules such as high molecular weight (HMW) plasma proteins IgA and IgM, viruses, VLPs, and PEGylated proteins. The stability of this base bead and its broad chemical compatibility allows repeated uses with a long resin lifetime. Nuvia HP-Q particle size is designed to offer high dynamic binding capacity (DBC) at fast flow rates without excessive backpressure, thereby delivering excellent process economics. Its pore size is optimized for easy accessibility and adsorption of large biomolecules, and the internal spacer length and ligand density facilitate efficient binding of the biomolecules even at high flow rates.
Features and Benefits
- Ideal for purification of large biomolecules
- Excellent pressure flow properties
- Recover more target biomolecule with less resin
- Increase productivity and decrease cycle time with high flow rates
- Easily scalable to meet manufacturing demands
- Improve overall process economics
Large Molecule Applications
- Plasma proteins IgA and IgM
- PEGylated proteins
Superior DBC of Nuvia HP-Q at a High Flow Rate Relative to Other Commercially Available Resins.
IgM obtained from plasma fractionation showed DBC in the range of 20-25 mg/ml with Nuvia HP-Q Resin. When compared to other commercially available resins, Nuvia HP-Q Resin demonstrated higher DBC at faster flow rates.
|Vendor/Product||Matrix Material||Particle Size, µm||Pressure, bar||Recommended Flow Rate, cm/hr1||DBC (IgM)|
|Resin 1||Dextran beads||50||<3||30||+++2|
|Nuvia HP-Q Media, 25 ml||12006693|
|Nuvia HP-Q Media, 100 ml||12006691|
|Nuvia HP-Q Media, 500 ml||12006660|
|Nuvia HP-Q Media, 5 L||12006659|
|Nuvia HP-Q Media, 10 L||12007023|
Foresight™ Nuvia HP-Q Column, 1 ml
Foresight Nuvia HP-Q Column, 5 ml
Foresight Nuvia HP-Q RoboColumn Unit, 200 μl
Foresight Nuvia HP-Q RoboColumn Unit, 600 μl
Foresight Nuvia HP-Q Plates, 20 μl
2% benzyl alcohol
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