ddSEQ Isolator for Single Cell Sequencing

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Overview

ddSEQ Single-Cell Isolator is a droplet-based single cell isolation system for single-cell chromatin accessibility studies. The system includes the isolator, test cartridges and the cartridge holder

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Description

Description

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The ddSEQ Single-Cell Isolator is part of the Bio-Rad Single-Cell Next-Generation Sequencing (NGS) Solution, which works with the Bio-Rad SureCell ATAC-Seq Kit. The technology utilizes disposable microfluidic cartridges to coencapsulate single cells or single nuclei and barcoded beads into subnanoliter droplets, where cell-bead pairing and barcoding occur. ATAC-Seq libraries are subsequently prepared and sequenced, and analysis is conducted with the Bio-Rad ATAC-Seq analysis pipeline. .

Features and Benefits

  • Process hundreds to tens of thousands of cells per experiment
  • Sensitive and unbiased characterization of chromatin accessibility or transcriptional signatures
  • Scalable solution to accommodate a wide range of experimental designs
  • Agnostic to mammalian cell size, enabling unbiased profiling of diverse cell populations
  • End-to-end single-cell sequencing solution with simple, powerful data analysis

Applications and Uses

  • Assess cell-to-cell heterogeneity and identify new sub-populations
  • Map genome-wide chromatin accessibility
  • Dissect transcriptional mechanics
  • Infer gene regulatory networks
  • Neurology research — normal brain function, neurological disease and psychological disorders
  • Immunology research — B Cell and T Cell characteristic and functional analyses
  • Cancer research — cellular expansion of clonal cells in tumors and mutations that lead to differences in gene expression and drug response
  • Stem cell research — cell fate, cell development and differentiation, including reverse engineering tissues

Included Components

  • ddSEQ Test Cartridges (12003862)
  • ddSEQ Cartridge Holder (12004739)
  • ddSEQ Single-Cell Isolator (12004336)
  • Power supply and power cord
  • User manual and product documentation

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12004336

ddSEQ Single-Cell Isolator is a droplet-based single cell isolation system for single-cell chromatin accessibility accessibility studies. The system includes the isolator, test cartridges and the cartridge holder

Accessories

Accessories

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12001925

Pkg of 25, clear well/clear shell semi-skirted plates, for use with QX200™/QX100™ or QX200™ AutoDG™ Droplet Digital™ PCR Systems

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1450102
120–240 V, includes instrument, power supply, USB flash drive, 30 dual-chamber counting slides (60 counts), 1.5 ml trypan blue
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1851197

Modular thermal cycler platform, includes C1000 Touch Thermal Cycler chassis, 96–deep well reaction module, USB flash drive

Documents

Documents

Number Description Options
7168
Droplet Digital™ Sequencing (ddSEQ™) Solution Publications List
10000069430
ddSEQ Single-Cell Isolator Instruction Manual