Overview
The Genesis System with Celselect Slides™ enable the capture of cells from liquid biopsies and other sample types.
The Celselect Slides utilizes 56,400 individual microchambers with a pore size that captures cells in the range of 8-30 µm (figure 1):
In Figure 2, red blood cells and smaller white blood cells flow through the pores while cells larger than 8 µm are captured. Circulating tumor cells (CTCs) and CTC clusters for the majority of cancers types are captured by the Celselect Slides.
Blood cell and CTC sizes relative to the Celselect Slides pore size.
After capture, the enriched cells can be recovered for downstream analysis such as single-cell genomics, digital PCR, or culture. Alternatively, cells can be immunolabeled on-slide for immunofluorescent applications such as enumeration.
For applications which require protocol optimization or creation of new protocols for custom reagents or antibody labeling, the Genesis Protocol Builder Software Tool enables adjustment of parameters such as reagent dispensing, pump pressures, and incubation settings. Building custom protocols is performed on your local computer.
Features and Benefits
- Size-based cell capture from liquid biopsies and other sample types
- Recover viable cells for downstream analysis or on-slide immunolabeling for enumeration
- Genesis Protocol Builder Software Tool enables optimization for different samples types or antibody stains
Celselect Slides Enumeration/Immunolabeling Workflow
Sample is prepared with fixing reagent and loaded on to the instrument. 8-30 µm sized cells are captured and immunolabeled automatically in the Celselect Slides microchambers while smaller components flow through the slide to waste. The Celselect Slides is imaged on an automated microscope and files can be imported for reporting.
Celselect Slide Enrichment Workflow
Sample is prepared with the dilution buffer and loaded on to the instrument. 8-30 µm sized cells are captured automatically in the Celselect Slides while smaller components (<8 µm) flow through the slide to waste.
Enriched cells are recovered in a single tube for downstream analysis, such as:
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Specifications
Instrument closed: 17.2” W x 23.0” D x 15.9” H
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The Genesis Cell Isolation System is designed for automated selection and capture of 8µm-30µm cells by size. It includes an intuitive touch-screen interface, integrated reagent dispensing and slide temperature control.
Kit sufficient for 4 samples, includes slides, reagents, and consumables for selection and capture/enrichment of cells.
Kit sufficient for 4 samples, includes slides, consumables and reagents to capture and prepare slides for immunolabeling (antibodies not included).
Kit sufficient for 4 samples, includes slides, consumables and reagents to capture and prepare slides for immunolabeling (antibodies not included).
The Genesis System Protocol Builder Software Tool comes on a USB with all necessary features to modify existing Genesis protocols as well as create new customized workflows.
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Analysis Software enables users to create custom algorithms to identify and analyze images of cells isolated and labeled on Celselect Slides
Analysis Software enables users to create custom algorithms to identify and analyze images of cells isolated and labeled on Celselect Slides