BioPlex™ 2200 Celiac IgA and IgG Panels

The BioPlex 2200 Celiac IgA and Celiac IgG panels detect and differentiate multiple celiac IgA and IgG antibodies and while simultaneously detecting IgA deficiency, helping to diagnose celiac disease with fewer separate tests.

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Overview

Celiac disease is an autoimmune disorder requiring accurate and timely diagnosis to manage effectively. Traditional celiac serology testing involves multiple separate serology tests, including tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP), and often requires an additional IgA deficiency test. Reflexive testing may also be required, including endomysial antibody (EMA) testing or human leukocyte antigen (HLA) testing, before biopsy is recommended. This testing can be complex, costly, and time-consuming for laboratories and patients.

The Power of Multiplex Celiac Testing

The BioPlex 2200 Celiac IgA and Celiac IgG panels provide a streamlined, fully automated solution. These multiplex panels detect and differentiate multiple celiac IgA and IgG antibodies while simultaneously screening for IgA deficiency—all in just two tests.

Celiac IgA

Tissue Transglutaminase (tTG) IgA
Deamidated Gliadin Peptide (DGP) IgA
IgA Verification Bead

Celiac IgG

Tissue Transglutaminase (tTG) IgG
Deamidated Gliadin Peptide (DGP) IgG

Key Benefits

Fewer Tests, More Insights — Generate four distinct celiac IgA and IgG results and identify IgA deficiency with just two tests.
Enhanced Workflow Efficiency — Eliminates separate reflex testing processes

“This fully automated, random access assay made our high-volume testing easier to manage – and I love that it is multiplexed, which detects IgA deficiency with tTG IgA in a single test.”

Jane Dickerson, PhD, DABCC
Division Head, Lab Medicine, Seattle Children's Hospital

Streamline Celiac Testing

Discover how the BioPlex 2200 Celiac IgA and BioPlex Celiac IgG panels transform celiac testing and workflow.

Test Smarter, Not Harder

With multiplex technology, the BioPlex 2200 Celiac panels replace up to five separate tests with just two, reducing calibration and quality control runs—saving time and resources.

See How Multiplex Results Simplify Testing

Click Clinical Indication

Normal

Celiac Disease - IgA Normal

Celiac Disease - IgA Deficient

BioPlex 2200 fully automated multiplex testing solution

Maximize Efficiency, Minimize Effort

Traditional celiac testing requires multiple screening and reflex steps. With the fully automated BioPlex 2200 System, simply load the samples and walk away— significantly reducing manual processing time.

BioPlex 2200 system consolidating EBV IgM and IgG testing

Test Consolidation: The Power of Simplicity

The BioPlex 2200 Celiac panels are part of a broad autoimmune and infectious disease test menu, allowing consolidation of more than 50 assays onto a single high-throughput system. This streamlines workflow, simplifies testing, and enhances efficiency.

Explore the BioPlex 2200 System

Improve Patient Care

Patient care is at the heart of what you do. From faster turnaround times to high-quality, clinically relevant results, we’ll help you help your patients.

Faster Result Turnaround Time

Quick and accurate diagnosis is critical for managing celiac disease. The BioPlex 2200 Celiac panels improve result turnaround time by delivering multiple results in a single test—eliminating the need for additional IgA testing and speeding up treatment decisions.

Help Reduce Invasive Celiac Testing

Confirming a diagnosis of celiac disease often involves duodenal biopsy—an invasive procedure that many patients, especially children, may wish to avoid.

The BioPlex 2200 Celiac Panels offer high specificity that can help reduce unnecessary biopsies by minimizing false positives.^1,2

In certain cases, significantly elevated tTG IgA levels may provide strong clinical confidence to support a diagnosis without the need for a biopsy,² as supported by ESPGHAN guidelines and clinical studies.^3*

Want to Learn More about Biopsy-free Pediatric Celiac Diagnosis?

Watch Dr. Jane Dickerson from Seattle Children’s Hospital present an evaluation of tTG-IgA on the BioPlex 2200 and a potential “biopsy-free” approach to celiac diagnosis.

Watch the webinar

Confidence in EVERY Patient Result

Integrated QC bead technology complements traditional quality controls by performing real-time analysis of assay parameters for every test. This means you can have confidence in every patient result.

Reduce Operational Costs

The BioPlex 2200 Celiac IgA and IgG panels can help your lab optimize testing processes and minimize costs.

Lower Test Processing Costs

By replacing up to five individual tests with only two, the BioPlex 2200 Celiac panels reduce the number of:

Test processes
Calibrations
Quality control runs
Reagent and consumable expenses

Reduce Labor & Staffing Costs

Multiplexing eliminates manual processes and hands-on time, reduces workload, and allows lab technologists to focus on other critical tasks.

Reduce Send-Out Testing Costs

Bringing celiac testing in-house minimizes outsourcing costs and improves operational efficiencies associated with send-out testing.

Case Study: Monthly Labor Time Comparison Table

See how you can reduce labor costs and make optimal use of medical laboratory technologists, your lab’s most valuable resource.

This case study compares the manual processing times required to perform celiac testing on the BioPlex 2200 System and on a competitor’s fully automated system. Data are based on a mid-size lab’s monthly celiac screen volume.

In addition to the time saved by eliminating separate IgA testing, multiplexed celiac testing requires 55% less hands-on time than competing automated tests.

For a personalized workflow analysis of your lab, please contact your Bio-Rad representatives.

Get My Workflow Analysis

Experience the BioPlex 2200 Advantage

The BioPlex 2200 Celiac IgA and IgG panels provide a comprehensive, automated, and cost-effective solution for celiac disease testing.
Enhance efficiency, reduce costs, and improve patient care—without the complexity of traditional celiac testing.

Notes

* Bio-Rad does not claim or endorse a no-biopsy approach to celiac diagnosis. Diagnosis procedures should be discussed between the patient, family, and specialist physician and follow established clinical guidelines.

References

1. Holding S et al. (2014). Clinical evaluation of the BioPlex 2200 Celiac IgA and IgG Kits — A novel multiplex screen incorporating an integral check for IgA deficiency. J Immunol Methods 405, 29-34.
2. Pacheco MC et al. (2022). Evaluation of BioPlex 2200 tTG-IgA diagnostic performance for serology-based diagnosis of celiac disease. Am J Clin Pathol 157, 136-139.
3. Husby S et al. (2020). European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. J Pediatr Gastroenterol Nutr 70, 141-157.

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