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Leveraging Genetic Manipulation Systems for Enhanced Biologics Production
It's no secret that monoclonal antibodies, hormones, clotting factors, and other biologics are taking the biopharmaceutical industry by storm. They have several advantages over small molecules, including greater target specificity and fewer side effects. One of the most challenging steps in developing novel biologics is cell line development. Continual innovation in methods for creating, choosing, and optimizing cells lines is essential to ensure that biologics development continues to improve.
Read this article to learn:
- How developing and maturing recombinant cell lines beyond the CHO system can enable the production of safer, more diverse biologics
- How streamlined genetic manipulation systems such as CRISPR and microRNAs can identify and leverage novel therapeutic targets
- How improved quality control will decrease cell line heterogeneity and increase a biologic’s quality
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