Seroprevalence Studies
Surveying the seroprevalence of antibodies to the SARS-CoV-2 virus is key to understanding local infection and exposure rates in specific areas or institutions. Because some people are asymptomatic and may not know they have been infected, population studies are crucial in modeling transmission in the COVID-19 pandemic.
Bio-Plex SARS-CoV-2 Antibody Assays provide flexible options to measure anti-SARS-CoV-2 IgG antibodies in a population. Samples can be assayed to measure any combination of antibodies against SARS-CoV-2 nucleocapsid protein, and spike protein subunits: receptor binding domain, spike, 1, and spike 2.
The Bio-Plex SARS-CoV-2 Antibody Assays are for research use only. Not for use in diagnostic procedures.
Publications for Multiplex Immunoassay Use in Seroprevalence Studies
- Fenwick C et al. (2020) Changes in SARS-CoV-2 Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies. medRxiv 2020.07.14.20153536; DOI: 10.1101/2020.07.14.20153536
- Kamminga S (2018) Seroprevalence of fourteen human polyomaviruses determined in blood donors. PLoS One. 2018 Oct 23;13(10):e0206273. DOI: 10.1371/journal.pone.0206273
- Kaur H et al. (2018) Evaluation of the reproducibility of a serological test for antibodies to Chlamydia trachomatis pgp3: A potential surveillance tool for trachoma programs. J Microbiol Methods. 2018 Apr;147:56-58. DOI: 10.1016/j.mimet.2018.02.017
Bio-Plex SARS-CoV-2 Assays
Multiplex SARS-CoV-2 Assay Human Serology Kits
Select complete, ready-to-use kits for multiplex target panels. For human serology samples only.
Individual SARS-CoV-2 Assay Components
Measure individual SARS-Cov-2 antibodies, or combine components to create multiplex assays. Viral protein coupled beads can be used for human samples and other species.
SARS-CoV-2 Assay Documents and Resources
Documents
Bio-Plex Pro Human SARS-CoV-2 Serology Assays Instruction Manual (PDF 601 KB)
Bio-Plex Pro Human SARS-CoV-2 N/RBD/S1/S2 4-Plex Panel Product Information Sheet (PDF 439 KB)
Bio-Plex Pro Human IgG SARS-CoV-2 Semi-Quantitative Assay Protocol (PDF 96 KB)
Bio-Plex Multiplex Systems Brochure (PDF 15.9 MB)
Learn about how how you can reduce time to results and samples while discovering more with Bio-Plex multiplex immunoassays, instruments, and software.
Bio-Plex Analyte Guide (PDF 2.2 MB)
Explore the different multiplex immunoassays and panels available on the Bio-Plex platform. Evaluate assay performance characteristics and sample data to choose the panel that fits your application.
Webinars
Role of Aberrant Cytokine Activity in Host Immune Response to COVID-19
In this webinar, we discuss early research and nascent hypotheses regarding the pathophysiology of SARS-CoV-2 induced COVID-19 disease by evaluating cytokine and chemokine profiles, the role of chronic inflammation in comorbidities, and the arc of immune resolution of historical virulent pathogens, such as SARS and MERS.
Multiplex Immunoassays in Vaccine Research and Development
In this presentation, we discuss how multiplex assays are being used on the front lines to understand patient immune response during infection, and discuss the most commonly asked questions around targets, panels, and multi-plate data analysis.
Vaccine Development and Manufacturing
In this talk, we review tips for overcoming developmental hurdles, technologies that can shorten timelines, and novel tools for manufacturing and quality control.
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Immunological Response Factors to SARS‑CoV‑2 in Acquired Immunity
In this webinar, we will discuss the immune response to SARS-CoV-2, both in the context of natural exposure to the virus and induced immunity from vaccination. We will also investigate the relationship between symptom severity and the longevity of acquired immunity.
More COVID-19 Surveillance Solutions
COVID-19 surveillance is needed to better inform public health decisions. Obstacles to surveillance work include large sample numbers, supply shortages, and complex sample types. Bio-Rad offers a range of solutions for COVID-19 surveillance.