Attend Our 15-Minute Ask the Expert Webcast on Purification of Bispecific and Trispecific Antibodies
Join us to explore strategies for overcoming purification challenges associated with structurally complex bispecific antibodies (BsAbs) and trispecific antibodies (TsAbs). Explore case studies demonstrating enhanced separation selectivity and the effective removal of aggregates, host cell DNA (hcDNA), and process-related impurities using CHT™ Ceramic Hydroxyapatite Media.
Technical Session
Thursday
8 AM PDT | 11 AM EDT | 5 PM CEST
Learn strategies for purifying structurally complex BsAbs and TsAbs using mixed-mode chromatography. Discover how CHT Ceramic Hydroxyapatite Media enhances separation selectivity and enables the effective removal of aggregates, hcDNA, and process related impurities within a single purification step. Explore real-world case studies demonstrating approaches to address downstream processing challenges associated with BsAbs and TsAbs.
Key Takeaways
- Learn how mixed-mode chromatography improves separation selectivity for BsAb and TsAb purification
- Discover approaches for removing aggregates, hcDNA, and process-related impurities in a single purification step
- Explore strategies for leveraging CHT Media to address downstream processing challenges for BsAbs and TsAbs
About the Presenter
Zhang Wei, PhD
Principal Scientist, Group Leader, Downstream Processing, A*STAR Bioprocessing Technology Institute, Singapore
Zhang Wei is a principal scientist leading the Downstream Processing Group (DSP) at the Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR) in Singapore. Her team focuses on purification process development and product characterization for a variety of biotherapeutics, including mAbs, BsAbs, vaccines, viral vectors, mRNA, and other emerging modalities. Her team at BTI also advances intensified and continuous downstream processing and actively collaborates with biopharmaceutical companies and technology providers worldwide.