BPI Asia Digital Series 2026
Join us for a day of real-world insights from industry experts in downstream processing and purification, exploring mixed-mode chromatography strategies for purifying mAbs, bispecific antibodies, and challenging biologics to boost yield while reducing process time, buffer use, and cost.
Wednesday
9:00 - 10:00 AM SGT
Purification Strategies for mAbs and Emerging Modalities Track
Key Takeaways
- Learn about a two-step mAb purification strategy using Nuvia aPrime mixed-mode resin to replace a polishing step after Protein A capture and reduce process time and buffer and media consumption, while improving yield
- Explore how unusual molecule properties defy standard purification platforms as well as strategies for developing and scaling robust downstream processes to cGMP manufacture
- Find out how CHT™ ceramic hydroxyapatite mixed-mode media clears aggregates, host cell DNA, and process impurities in a single step, especially for challenging BsAbs and TsAbs
Speakers
Marian Magdy
R&D Purification Manager, R&D Biopharmaceutical Process Development Department, Minapharm Pharmaceuticals
Christopher Fox, MSc
Senior Technical Project Leader, Process Development, FUJIFILM Biotechnologies
Zhang Wei, PhD
Principal Scientist, Group Leader, Downstream Processing, A*STAR Bioprocessing Technology Institute, Singapore
Agenda
Wednesday
9:00 AM
A Two-Step Approach Using a Mixed-Mode Resin for mAb Purification
This case study presents a two-step mAb purification strategy using Nuvia aPrime mixed-mode resin to replace a polishing step after Protein A capture and reduce process time and buffer and media consumption, while improving yield.
Speaker: Marian Magdy
Wednesday
9:20 AM
Developing Bespoke Purification Strategies for Challenging Biologics
This session explores how unusual molecule properties defy standard purification platforms and offers strategies for developing and scaling robust downstream processes to cGMP manufacture.
Speaker: Christopher Fox, MSc
Wednesday
9:40 AM
Enhancing Bispecific and Trispecific Antibody Purification Using Mixed-Mode Chromatography
BsAbs and TsAbs are challenging to purify due to their structural complexity. This presentation shows how CHT™ ceramic hydroxyapatite mixed-mode media clears aggregates, host cell DNA, and process impurities in a single step.
Speaker: Zhang Wei, PhD