21st International PhD Seminar on Chromatographic Separation Science (SoCSS)
Join Bio-Rad at SoCSS to discover how our process chromatography solutions support efficient method and process development for biopharmaceutical manufacturing. Learn innovative approaches, gain practical insights, and connect with experts to optimize your workflows.
22–25 June
Forschungscampus
Waischenfeld, Germany
Technical Session
Tuesday
10:10–10:30 AM CEST
Scalable ADC Purification With Mixed‑Mode Chromatography
This seminar highlights an advanced purification strategy for emtansine biosimilar antibody‑drug conjugates (ADCs) using mixed‑mode chromatography to address critical impurity challenges. Learn how selective interactions enable effective removal of aggregates and high DAR (drug‑to‑antibody ratio) species while enriching the desired monomeric ADC profile. The session also demonstrates how ceramic hydroxyapatite chromatography delivers a scalable and reproducible solution to improve product quality and consistency in ADC manufacturing.
Speaker
Evelyn Schwendy
Process Chromatography Specialist
Bio-Rad Laboratories