Bio-Rad's hydroxyapatite resin products are licensed under U.S. Pat. App. No. 2005/0107594, and U.S. Pat. No. 8,058,407, as well as all foreign equivalents of the foregoing, including EP1678208B1, CN1898266B, and JP5004586B2. Bio-Rad's hydroxyapatite resin products are not licensed under the foregoing patents and applications for the commercial manufacture of the Pfizer, Inc. products listed below, including generic or biosimilar versions thereof. This list may be updated in the future. The manufacture of listed products already in production by a purchaser of Bio-Rad's hydroxyapatite resin products prior to the date a product is added to the list below shall not be subject to the foregoing license restrictions.
Listed products. Rev A. June 14th, 2013:
Benefix (Coagulation Factor IX)
Neisseria meningitidis Serogroup B Recombinant Lipoprotein Vaccine (Meningococcal B vaccine)
Bio-Rad patents and applications relating to hydroxyapatite resin products:
The purchase of hydroxyapatite resin from Bio-Rad Laboratories confers to the purchaser the right to use such resin in the applications and methods claimed in the following patents and patent applications.
| Title | Publication No. |
|
|---|---|---|
| Acetate-Free Purification of Plasmid DNA on Hydroxyapatite | 6,406,892 | |
| Enhanced Capacity and Purification of Antibodies by Mixed Mode Chromatography in the Presence of Aqueous-Soluble Nonionic Organic Polymers | 7,691,980 | |
| Enhanced Capacity and Purification of Antibodies by Mixed Mode Chromatography in the Presence of Aqueous-Soluble Nonionic Organic Polymers | 7,999,085 | |
| Enhanced Capacity and Purification of Antibodies by Mixed Mode Chromatography in the Presence of Aqueous-Soluble Nonionic Organic Polymers | 8,017,740 | |
| Enhanced Capacity and Purification of Antibodies by Mixed Mode Chromatography in the Presence of Aqueous-Soluble Nonionic Organic Polymers | US2013/0263823 | |
| Purification of IgG by Mixed Mode Chromatography | 8,188,242 | |
| Purification of IgG by Mixed Mode Chromatography | US2012/0264915 | |
| Surface Neutralization of Apatite | US2011/0178276 | |
| Enhanced Purification of Phosphorylated and Non Phosphorylated Biomolecules by Apatite Chromatography | US2009/0186396 | |
| Enhanced Purification of Antibodies and Antibody Fragments by Apatite Chromatography | 8,093,364 | |
| Enhanced Purification of Antibodies and Antibody Fragments by Apatite Chromatography | US2012/0077961 | |
| Elution of Proteins from Hydroxyapatite Resins without Resin Deterioration | US2012/0202975 | |
| Apatite Surface Neutralization with Alkali Solutions | US2012/0192901 | |
| Purification of Immunoconjugates | 8,481,694 | |
| Dissociation of Product-Complexed Contaminants in Chromatography | US2012/0252098 | |
| Removal of Virucidal Agents from Biomolecule Preparations | US2013/0267690 | |
| Fractionation of Phosphorylated Proteins and Peptides on Ceramic Hydroxyapatite | US2010/0125128 | |
| In Situ Restoration of Apatite-Based Chromatography Resins | US2013/0323812 |