Beta-2 adrenergic-dependent CFTR expression

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Beta-adrenergic-dependent CFTR expression

Beta-adrenergic receptor modulates expression of the Cystic fibrosis transmembrane conductance regulator (CFTR) [1] via elevation of Adenosine 3',5'-cyclic phosphate -(cAMP) mediated by GNAS complex locus (G-protein alpha-s)/ Adenylate cyclase/ cAMP. High cAMP concentration leads to activation of the PKA and, subsequently, of cAMP responsive element binding protein 1 (CREB1) and transcription factor 1 (ATF-1)-dependent transcription of CFTR. cAMP-dependent activation of CFTR transcription is still being studied and appears to be more complex than believed previously [1], [2], [3].

References:

  1. Matthews RP, McKnight GS
    Characterization of the cAMP response element of the cystic fibrosis transmembrane conductance regulator gene promoter. The Journal of biological chemistry 1996 Dec 13;271(50):31869-77
  2. Pittman N, Shue G, LeLeiko NS, Walsh MJ
    Transcription of cystic fibrosis transmembrane conductance regulator requires a CCAAT-like element for both basal and cAMP-mediated regulation. The Journal of biological chemistry 1995 Dec 1;270(48):28848-57
  3. McDonald RA, Matthews RP, Idzerda RL, McKnight GS
    Basal expression of the cystic fibrosis transmembrane conductance regulator gene is dependent on protein kinase A activity. Proceedings of the National Academy of Sciences of the United States of America 1995 Aug 1;92(16):7560-4

  1. Matthews RP, McKnight GS
    Characterization of the cAMP response element of the cystic fibrosis transmembrane conductance regulator gene promoter. The Journal of biological chemistry 1996 Dec 13;271(50):31869-77
  2. Pittman N, Shue G, LeLeiko NS, Walsh MJ
    Transcription of cystic fibrosis transmembrane conductance regulator requires a CCAAT-like element for both basal and cAMP-mediated regulation. The Journal of biological chemistry 1995 Dec 1;270(48):28848-57
  3. McDonald RA, Matthews RP, Idzerda RL, McKnight GS
    Basal expression of the cystic fibrosis transmembrane conductance regulator gene is dependent on protein kinase A activity. Proceedings of the National Academy of Sciences of the United States of America 1995 Aug 1;92(16):7560-4

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