Gene:  NLRP3, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes a pyrin-like protein containing a pyrin domain a nucleotide-binding site (NBS) domain and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC which contains a caspase recruitment domain and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling and it plays a role in the regulation of inflammation the immune response and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS) Muckle-Wells syndrome (MWS) chronic infantile neurological cutaneous and articular (CINCA) syndrome and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq Oct 2008]

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PrimePCR™ SYBR® Green Assay: NLRP3, Human
NLR family, pyrin domain containing 3

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0036694
Info:   Same primer pair as used in probe assay qHsaCIP0039418
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PrimePCR™ Probe Assay: NLRP3, Human
NLR family, pyrin domain containing 3

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0039418
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PrimePCR™ ddPCR™ Mutation Assay:NLRP3 p.L919L, Human
NLR family, pyrin domain containing 3

Assay Type: Probe
Application: In Silico Mutation Detection
Unique Assay ID: dHsaIS2502692
Info:   65nt amplicon; exonic; in-silico designed
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:NLRP3 WT for p.L919L, Human
NLR family, pyrin domain containing 3

Assay Type: Probe
Application: In Silico Mutation Detection
Unique Assay ID: dHsaIS2502693
Info:   65nt amplicon; exonic; in-silico designed
 
Fluorophore:   HEX
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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