Gene:  CDKN2A, Human

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This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with and sequester MDM1 a protein responsible for the degradation of p53. In spite of the structural and functional differences the CDK inhibitor isoforms and the ARF product encoded by this gene through the regulatory roles of CDK4 and p53 in cell cycle G1 progression share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors and is known to be an important tumor suppressor gene. [provided by RefSeq Jul 2008]

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PrimePCR™ SYBR® Green Assay: CDKN2A, Human
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0023006
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PrimePCR™ SYBR® Green Assay: CDKN2A, Human
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0056722
Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0057827
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PrimePCR™ Probe Assay: CDKN2A, Human
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0057827
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PrimePCR™ ddPCR™ Copy Number Assay: CDKN2A, Human
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP1000581
 
Fluorophore:   FAM
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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