Gene:  ARNT, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand which includes dioxin and polycyclic aromatic hydrocarbons results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor hypoxia-inducible factor 1. A t(1;12)(q21;p13) translocation which results in a TEL-ARNT fusion protein is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq Oct 2010]

PrimePCR™ SYBR® Green Assay: ARNT, Human
aryl hydrocarbon receptor nuclear translocator

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0009053
Info:   Same primer pair as used in probe assay qHsaCIP0027033
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PrimePCR™ Probe Assay: ARNT, Human
aryl hydrocarbon receptor nuclear translocator

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0027033
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