Gene:  TRAF6, Human

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The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40 TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK SRC and PKCzeta which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13 and UBE2V1/UEV1A which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs a central coiled-coil region and a highly conserved carboxyl terminal domain known as the TRAF-C domain. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq Feb 2012]

PrimePCR™ SYBR® Green Assay: TRAF6, Human
TNF receptor-associated factor 6

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0012893
Info:   Same primer pair as used in probe assay qHsaCIP0028638
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PrimePCR™ Probe Assay: TRAF6, Human
TNF receptor-associated factor 6

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0028638
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Number Description Download
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LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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