Gene:  TP53, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes tumor protein p53 which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest apoptosis senescence DNA repair or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation DNA-binding and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms which can regulate p53 transcriptional activity. [provided by RefSeq Jul 2008]

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PrimePCR™ SYBR® Green Assay: TP53, Human
tumor protein p53

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0045022
Info:   Same primer pair as used in probe assay qHsaCEP0052284
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PrimePCR™ SYBR® Green Assay: TP53, Human
tumor protein p53

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0013658
Info:   Recommended - best coverage
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PrimePCR™ Probe Assay: TP53, Human
tumor protein p53

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0052284
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PrimePCR™ ddPCR™ Copy Number Assay: TP53, Human
tumor protein p53

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP1000586
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay: TP53 p.R249S, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000087
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay: TP53 WT for p.R249S, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000088
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay: TP53 p.Y163C, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000099
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay: TP53 WT for p.Y163C, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000100
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay: TP53 p.R175H, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000105
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay: TP53 WT for p.R175H, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000106
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay: TP53 p.R248W, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000107
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay: TP53 WT for p.R248W, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000108
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay: TP53 p.R273H, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000109
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay: TP53 WT for p.R273H, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000110
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay: TP53 p.R196*, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000121
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay: TP53 WT for p.R196*, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000122
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay: TP53 p.H179R, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000125
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay: TP53 WT for p.H179R, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000126
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay: TP53 p.R248Q, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000127
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay: TP53 WT for p.R248Q, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000128
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay: TP53 p.V157F, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000129
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay: TP53 WT for p.V157F, Human
tumor protein p53

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000130
 
Fluorophore:   HEX
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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