Gene:  TNFSF10, Human

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The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1 TNFRSF10B/TRAILR2 TNFRSF10C/TRAILR3 TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3 TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK caspase 8 and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2010]

PrimePCR™ SYBR® Green Assay: TNFSF10, Human
tumor necrosis factor (ligand) superfamily, member 10

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0036477
Info:   Same primer pair as used in probe assay qHsaCEP0039201
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PrimePCR™ Probe Assay: TNFSF10, Human
tumor necrosis factor (ligand) superfamily, member 10

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0039201
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Number Description Download
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LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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