Gene:  SMAD1, Human

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The protein encoded by this gene belongs to the SMAD a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs) which are involved in a range of biological activities including cell growth apoptosis morphogenesis development and immune responses. In response to BMP ligands this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4 which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases such as SMURF1 and SMURF2 and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: SMAD1, Human
SMAD family member 1

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0037732
Info:   Same primer pair as used in probe assay qHsaCEP0040455
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PrimePCR™ Probe Assay: SMAD1, Human
SMAD family member 1

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0040455
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Number Description Download
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LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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