Gene:  SHANK2, Human

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This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction including ankyrin repeats an SH3 domain a PSD-95/Dlg/ZO-1 domain a sterile alpha motif domain and a proline-rich region. This particular family member contains a PDZ domain a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants encoding distinct isoforms are reported. Additional splice variants exist but their full-length nature has not been determined. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: SHANK2, Human
SH3 and multiple ankyrin repeat domains 2

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0021499
Info:   Same primer pair as used in probe assay qHsaCIP0033063
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PrimePCR™ Probe Assay: SHANK2, Human
SH3 and multiple ankyrin repeat domains 2

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0033063
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