Gene:  SH2D1A, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T B and NK cells thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

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PrimePCR™ SYBR® Green Assay: SH2D1A, Human
SH2 domain containing 1A

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0007517
Info:   Same primer pair as used in probe assay qHsaCIP0026498
List Price:    $125.00
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PrimePCR™ Probe Assay: SH2D1A, Human
SH2 domain containing 1A

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0026498
List Price:    $180.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: SH2D1A, Human
SH2 domain containing 1A

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5015147
Info:   EG; Same primer pair as used in qPCR assay qHsaCID0007517; Intron-spanning
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression Probe Assay: SH2D1A, Human
SH2 domain containing 1A

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5047356
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0026498; Intron-spanning
 
Fluorophore:   FAM
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression Probe Assay: SH2D1A, Human
SH2 domain containing 1A

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5047357
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0026498; Intron-spanning
 
Fluorophore:   HEX
List Price:    $190.00
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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