Gene:  RAN, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which in turn induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq Jul 2008]

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PrimePCR™ SYBR® Green Assay: RAN, Human
RAN, member RAS oncogene family

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0004857
List Price:    $125.00
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PrimePCR™ SYBR® Green Assay: RAN, Human
RAN, member RAS oncogene family

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0044432
Info:   Same primer pair as used in probe assay qHsaCEP0051694
List Price:    $125.00
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PrimePCR™ Probe Assay: RAN, Human
RAN, member RAS oncogene family

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0051694
List Price:    $180.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: RAN, Human
RAN, member RAS oncogene family

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5002983
Info:   EG; Same primer pair as used in qPCR assay qHsaCED0004857; Exonic
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: RAN, Human
RAN, member RAS oncogene family

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5189122
Info:   EG; Same primer pair as used in qPCR assay qHsaCED0044432; exonic
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression Probe Assay: RAN, Human
RAN, member RAS oncogene family

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5191935
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0051694; exonic
 
Fluorophore:   FAM
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression Probe Assay: RAN, Human
RAN, member RAS oncogene family

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5191936
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0051694; exonic
 
Fluorophore:   HEX
List Price:    $190.00
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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