Gene:  PTTG1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The encoded protein is a homolog of yeast securin proteins which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs which are required for its transforming and tumorigenic activities as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein although it partially localizes in the nucleus. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: PTTG1, Human
pituitary tumor-transforming 1

Assay Type: SYBR® Green
Assay Design: intron_spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0038120
Info:   Same primer pair as used in probe assay qHsaCIP0040843
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PrimePCR™ Probe Assay: PTTG1, Human
pituitary tumor-transforming 1

Assay Type: Probe
Assay Design: intron_spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0040843
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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