Gene:  PTPN1, Human

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The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitotic cycle and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase as well as JAK2 and TYK2 kinases which implicated the role of this PTP in cell growth control and cell response to interferon stimulation. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: PTPN1, Human
protein tyrosine phosphatase, non-receptor type 1

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0015173
Info:   Same primer pair as used in probe assay qHsaCIP0029758
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PrimePCR™ Probe Assay: PTPN1, Human
protein tyrosine phosphatase, non-receptor type 1

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0029758
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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