Gene:  PTK2B, Human

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This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration nicotinic acetylcholine receptor activation membrane depolarization or protein kinase C activation. This protein has been shown to bind CRK-associated substrate nephrocystin GTPase regulator associated with FAK and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: PTK2B, Human
PTK2B protein tyrosine kinase 2 beta

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0021171
Info:   Same primer pair as used in probe assay qHsaCIP0032942
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PrimePCR™ Probe Assay: PTK2B, Human
PTK2B protein tyrosine kinase 2 beta

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0032942
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