Gene:  PSME2, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base which contains 6 ATPase subunits and 2 non-ATPase subunits and a lid which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome the immunoproteasome is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator referred to as the 11S regulator or PA28 that replaces the 19S regulator. Three subunits (alpha beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4 5 8 10 and 13. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: PSME2, Human
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0038914
Info:   Same primer pair as used in probe assay qHsaCEP0041636
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PrimePCR™ Probe Assay: PSME2, Human
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0041636
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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